Results 21 to 30 of about 40,475 (185)

A Global Perspective of Childhood Vaccinations: Past, Present, and Future-From Smallpox to mRNA. [PDF]

Acta Paediatr
ABSTRACT Childhood immunisation is one of the most successful public health interventions in history, preventing millions of deaths and substantially reducing global child mortality. This mini‐review summarises the historical development of childhood vaccines, the role of global coordination in expanding immunisation coverage, and the innovations that ...
Alfvén T, Reza T, Sowe A.
europepmc   +2 more sources

Long-term effects of smallpox vaccination on expression of the HIV-1 co-receptor CCR5 in women. [PDF]

PLoS ONE, 2018
BACKGROUND:Smallpox vaccinations were stopped globally in 1980. Recent studies have shown that in women, being smallpox vaccinated was associated with a reduced risk of HIV infection compared with not being smallpox vaccinated.
K B Beck, B L Hønge, J S Olesen, M S Petersen, S Jespersen, C Wejse, Z J da Silva, C Medina, D D S Té, B K Moeller, C S Benn, P Aaby, C Erikstrup   +12 more
doaj   +1 more source

Acute Late-Stage Myocarditis in the Crab-Eating Macaque Model of Hemorrhagic Smallpox

Viruses, 2021
Hemorrhagic smallpox, caused by variola virus (VARV), was a rare but nearly 100% lethal human disease manifestation. Hemorrhagic smallpox is frequently characterized by secondary bacterial infection, coagulopathy, and myocardial and subendocardial ...
Reed F. Johnson, Lauren A. Keith, Timothy K. Cooper, Srikanth Yellayi, Nicole M. Josleyn, Krisztina B. Janosko, James D. Pettitt, David Thomasson, Katie R. Hagen, Robin Gross, John G. Bernbaum, Debbie Douglas, Jeffrey Solomon, Mark Martinez, Kurt Cooper, Marisa St. Claire, Danny R. Ragland, Peter B. Jahrling, Jens H. Kuhn, Andrew E. Arai   +19 more
doaj   +1 more source

History of Smallpox

Journal of Nepal Medical Association, 2003
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P N Shrestha
doaj   +1 more source

The origins and genomic diversity of American Civil War Era smallpox vaccine strains

Genome Biology, 2020
Vaccination has transformed public health, most notably including the eradication of smallpox. Despite its profound historical importance, little is known of the origins and diversity of the viruses used in smallpox vaccination.
Ana T. Duggan, Jennifer Klunk, Ashleigh F. Porter, Anna N. Dhody, Robert Hicks, Geoffrey L. Smith, Margaret Humphreys, Andrea M. McCollum, Whitni B. Davidson, Kimberly Wilkins, Yu Li, Amanda Burke, Hanna Polasky, Lowell Flanders, Debi Poinar, Amogelang R. Raphenya, Tammy T. Y. Lau, Brian Alcock, Andrew G. McArthur, G. Brian Golding, Edward C. Holmes, Hendrik N. Poinar   +21 more
doaj   +1 more source

Progression of pathogenic events in cynomolgus macaques infected with variola virus. [PDF]

PLoS ONE, 2011
Smallpox, caused by variola virus (VARV), is a devastating human disease that affected millions worldwide until the virus was eradicated in the 1970 s.
Victoria Wahl-Jensen, Jennifer A Cann, Kathleen H Rubins, John W Huggins, Robert W Fisher, Anthony J Johnson, Fabian de Kok-Mercado, Thomas Larsen, Jo Lynne Raymond, Lisa E Hensley, Peter B Jahrling   +10 more
doaj   +1 more source

Smallpox, Monkeypox and Other Human Orthopoxvirus Infections

Viruses, 2022
Considering that vaccination against smallpox with live vaccinia virus led to serious adverse effects in some cases, the WHO, after declaration of the global eradication of smallpox in 1980, strongly recommended to discontinue the vaccination in all ...
Galina A. Shchelkunova, Sergei N. Shchelkunov   +1 more
doaj   +1 more source

Remaining Questions about Clinical Variola Major

Emerging Infectious Diseases, 2011
After the recent summary of World Health Organization–authorized research on smallpox, several clinical issues remain. This policy review addresses whether early hemorrhagic smallpox is disseminated intravascular coagulation and speculates about the ...
J. Michael Lane
doaj   +1 more source

The rediscovery of smallpox [PDF]

Clinical Microbiology and Infection, 2014
Smallpox is an infectious disease that is unique to humans, caused by a poxvirus. It is one of the most lethal of diseases; the virus variant Variola major has a mortality rate of 30%. People surviving this disease have life-long consequences, but also assured immunity. Historically, smallpox was recognized early in human populations.
Thèves, Catherine, Biagini, Philippe, Crubézy, Eric   +2 more
openaire   +2 more sources

Patterns of smallpox mortality in London, England, over three centuries.

PLoS Biology, 2020
Smallpox is unique among infectious diseases in the degree to which it devastated human populations, its long history of control interventions, and the fact that it has been successfully eradicated.
Olga Krylova, David J D Earn
doaj   +1 more source