Results 151 to 160 of about 119,561 (298)

Economic evaluations of antiobesity medications: A systematic literature review

British Journal of Clinical Pharmacology, EarlyView.
The global prevalence of obesity is rising rapidly. With several antiobesity medications approved and many more in development, understanding their economic value is increasingly important. This study reviews full economic evaluations of approved antiobesity medications to assess cost‐effectiveness and inform reimbursement and access decisions.
Martina Jurković, Almir Fajkić, Andrea Katrin Faour, Mirna Momčilović, Petra Turčić, Andrej Belančić   +5 more
wiley   +1 more source

Smc/ScpAB condensin 단백질의 구조적 연구

, 2013
학위논문(박사) - 한국과학기술원 : 생명과학과, 2013.2, [ v, 71 p. ]Chromosomes are condensed form in all living organisms. In prokaryotes, three groups of chromosome condensin complexes have been identified, Smc/ScpAB, MukBEF and a related MksBEF.
Shin, Ho-Chul, 신호철
core   +1 more source

Safety and pharmacokinetics of inhaled aloxistatin: A first‐in‐human phase 1 dose escalation trial

British Journal of Clinical Pharmacology, EarlyView.
Aims Aloxistatin (E64d) is a membrane‐permeable cysteine protease inhibitor prodrug that is converted by esterases to the active metabolite E64c (loxistatin). This first‐in‐human study evaluated the safety, tolerability and pharmacokinetics of single ascending doses of inhaled E64d in healthy volunteers.
Sebastian Fähndrich, Franziska Friedrich, Daniel Soriano, Jona Gjeloshi, Björn C. Frye, Xuan Phuoc Nguyen, Lydia Herbstritt, Caroline von Spee‐Mayer, Britta Lang, Fabrice Nollevaux, Andreas Hoheisel, Dorothee Winterberg, Armin Braun, Thomas Epting, Christine Contini, Karl Winkler, Thomas Reinheckel, Franziska C. Trudzinski, Gernot Rohde, Daiana Stolz, Robert Bals, Martin J. Hug, Sebastian Wirtz, Christoph Peters, Carolin Jenkner   +24 more
wiley   +1 more source

Widening participation and the changing risks of higher education: Working‐class women's pathways via access courses across two decades

British Educational Research Journal, EarlyView.
Abstract Widening participation (WP) in higher education (HE) remains a central concern within UK educational and social policy. It seeks to address the underrepresentation of specific social groups by tailoring university access to their distinct needs.
Sarah McLaughlin, Richard Waller
wiley   +1 more source

Fibroproliferative Remodeling of Immune‐Vascular Co‐Culture Spheroid Models in Response to Atherogenic Stimulation

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Cell‐based models are highly valuable platforms for preclinical studies of atherosclerosis, offering controllable environments to investigate disease mechanisms. Three‐dimensional (3D) spheroids, a class of cell‐based models, enable the study of atherosclerotic disease phenomena under physiologically relevant yet controlled conditions. In this
Ibukunoluwa Naiyeju, Stephanie Lehoux, Maryam Tabrizian   +2 more
wiley   +1 more source

Green Intellectual Capital, Sustainability Control Systems, and Environmental Performance: Bridging Natural Resource Orchestration and Levers of Control Perspectives

Business Strategy and the Environment, EarlyView.
ABSTRACT Understanding how organizations translate sustainability‐oriented intangible assets into tangible environmental outcomes remains an important challenge in sustainability accounting and management control research. Drawing on the natural resource orchestration perspective, this study examines how sustainability control systems, grounded in ...
Kaveh Asiaei, Shallini Taneja, Sangeeta Wats, Mahesh Joshi, Omid Barani   +4 more
wiley   +1 more source

Dual‐Pronged Strategy for Practical H2O2 Electrosynthesis: Cross‐Scale Engineering of Nanocarbon Catalysts

Carbon Energy, EarlyView.
This work integrates cross‐scale engineering of surface active sites and mesoscale mass transport in nanocarbon electrocatalysts to enable efficient two‐electron oxygen reduction reaction (2e− ORR) at industrially relevant current densities, generating practical H2O2 solutions for pulp bleaching and medical‐grade disinfection, while providing ...
Lingyan Jing, Wanyue Yuan, Yan Li, Zehua Zheng, Aokang Li, Kunlin Xie, Leyang Li, Xiaojing Huang, Qiang Tian, Jinlong Yang, Chuanxin He   +10 more
wiley   +1 more source

Tailoring Liquid Crystalline Self‐Assembly and Photophysical Properties of Unsymmetrical Fluorenones via Polar Terminal Groups

Chemistry – A European Journal, EarlyView.
Novel liquid crystalline fluorenones bearing various head groups were synthesized and characterized. By alteration of the head group, N, SmC, or SmA phases were obtained, and emission properties could be tuned depending on solvent or temperature. ABSTRACT In this work, a series of novel unsymmetrical fluorenone derivatives bearing various head groups ...
Falk Feucht, Franziska Müller, Johanna Osterbrink, Anna Zens, Yann Molard, Sabine Laschat   +5 more
wiley   +1 more source

The Association of Seasonal Malaria Chemoprevention with Educational Outcomes in Senegal, 2013-2019: A District-Level Ecological Analysis. [PDF]

Am J Trop Med Hyg
Ndiaye M, Bisanzio D, Gove A, Cohee LM, Reithinger R.   +4 more
europepmc   +1 more source

Loss of POGLUT2/3‐mediated O‐glucosylation produces lung and aortic phenotypes reminiscent of fibrillin1 mutants

Developmental Dynamics, EarlyView.
Abstract Background Fibrillins provide a scaffold for elastic fiber formation, which enables lung recoil and aortic compliance. Abnormal fibrillin microfibrils, as in Marfan syndrome, lead to enlarged alveoli, vascular stiffening, and aneurysms. Our earlier studies suggested that fibrillin function depends on O‐glucosylation of its epidermal growth ...
Sanjiv Neupane, Angelina Almiroudis, Kaitlyn E. Donnelly, Robert S. Haltiwanger, Bernadette C. Holdener   +4 more
wiley   +1 more source