Results 41 to 50 of about 71,027 (265)

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Phase Field Failure Modeling: Brittle‐Ductile Dual‐Phase Microstructures under Compressive Loading

Advanced Engineering Materials, EarlyView.
The approach by Amor and the approach by Miehe and Zhang for asymmetric damage behavior in the phase field method for fracture are compared regarding their fitness for microcrack‐based failure modeling. The comparison is performed for the case of a dual‐phase microstructure with a brittle and a ductile constituent.
Jakob Huber, Jan Torgersen, Ewald Werner
wiley   +1 more source

Epidemiology of Malaria Cases, Sunyani Municipality, Ghana, 2020

Journal of Interventional Epidemiology and Public Health
Introduction: Malaria is endemic in Ghana, accounting for about 40% of all Outpatient Department (OPD) diagnoses. Data on malaria is routinely collected as part of the IDSR monthly reporting forms. Sunyani municipality recorded 56,540 malaria cases in
Abdul Gafaru Mohammed, Christopher Sunkwa Tamal, Magdalene Akos Odikro, Charles Lwanga Noora, Prince Romeo Quarshie, Edwin Andrew Afari, Ernest Kenu   +6 more
doaj   +1 more source

Real Time Performance Comparison of Buck Converter Circuit Controlled By Discrete Time PID, LQR and SMC Controllers in Continuous-Current Mode

Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 2019
In this study, a DC-DC buckconverter circuit which is used to get direct voltage by decreasing the sourcevoltage is researched. Firstly mathematical model for a DC-DC buck convertercircuit is obtained and critical inductance value is calculated to make ...
Ömer Özdemir, İrfan Yazıcı
doaj   +1 more source

Tissue‐Adhesive Fabric‐Based Bioelectronics for Wearable and Implantable Applications

Advanced Functional Materials, EarlyView.
An implantable and wearable bioelectronic textile (iTextile) is introduced as a unified platform bridging wearable and implantable systems. By integrating a self‐healing polymer, stretchable silk fabric, conductive composite electrodes, and an adhesive hydrogel, the platform enables conformal, stable interfacing with soft tissues. The iTextile supports
Soojung An, Yewon Kim, Kyoungryong Kim, Heewon Choi, Sungjun Yoon, Jaewon Ju, Mikyung Shin, Donghee Son   +7 more
wiley   +1 more source

Comparison of discrete-time smc, LQR and PID controllers performance on DC-DC buck converter

Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 2018
Bu çalışmada, sürekli-akım modunda çalıştırılanalçaltıcı tip Da-Da dönüştürücüler için ayrık-zamanda üç farklı kontrolörtasarlanmış ve benzetim çalışmaları ile performansları karşılaştırmalı olarakincelenmiştir.
Ömer Özdemir, İrfan Yazıcı
doaj   +1 more source

Cellular Responses to Mechanical Cues Across Scales: From Fundamental Insights to Translational Potential

Advanced Healthcare Materials, EarlyView.
This review examines how cellular behavior is regulated by mechanical cues transmitted through soft biomaterials, from single‐cell mechanosensing to tissue‐level adaptation. It highlights why physiological relevance, rather than model complexity alone, is critical for translational mechanobiology and introduces a scoring framework linking material ...
Mathias Polz, Manuel P. Kainz, Niklas Haider, Theresa Rienmüller, Kerstin Lenk, Rupert Kargl, Michele Terzano, Gerhard Sommer, Gerhard A. Holzapfel, Julia Fuchs   +9 more
wiley   +1 more source

Is the SMC Bound to the LMC? The HST Proper Motion of the SMC

, 2006
We present a measurement of the systemic proper motion of the Small Magellanic Cloud (SMC) made using the Advanced Camera for Surveys (ACS) on the \textit{Hubble Space Telescope} (\textit{HST}). We tracked the SMC's motion relative to 4 background QSOs over a baseline of approximately 2 years.
Kallivayalil, Nitya, van der Marel, Roeland P., Alcock, Charles   +2 more
openaire   +2 more sources

Biomimetic Vascular Scaffold with Seamless Electrospun Aligned Nanofiber Conduit and 3D‐Printed Coil Reinforcement

Advanced Healthcare Materials, EarlyView.
We introduce a new fabrication method that overcomes the current limitation of tubular gap electrospinning. We successfully fabricated a seamless hollow tube with fibers aligned along the longitudinal axis in diameters as small as 300 µm, and then reinforced it using 4‐axis 3D printing.
Seyed Aliakbar Hosseini Toopghara, Young‐Ook Hwang, In A Kim, Che‐I Hyun, Hochung Ryu, Won‐Jae Kim, Jeong‐Tae Koh, Hyun‐Pil Lim, Jin‐Ho Kang, Sang‐Won Park   +9 more
wiley   +1 more source

Hybrid Adaptive Neural Network AUV controller design with Sliding Mode Robust Term

International Journal of Maritime Technology, 2017
This work addresses an autonomous underwater vehicle (AUV) for applying nonlinear control which is capable of disturbance rejection via intelligent estimation of uncertainties. Adaptive radial basis function neural network (RBF NN) controller is proposed
Behdad Geranmehr, Kamran Vafaee
doaj