Results 111 to 120 of about 6,254 (216)

Hierarchically-coupled hidden Markov models for learning kinetic rates from single-molecule data [PDF]

, 2013
We address the problem of analyzing sets of noisy time-varying signals that all report on the same process but confound straightforward analyses due to complex inter-signal heterogeneities and measurement artifacts.
Bronson, Jonathan E., Gonzalez Jr., Ruben L., van de Meent, Jan-Willem, Wiggins, Chris H., Wood, Frank   +4 more
core  

Structural Insights into Metabolite-Sensing Messenger RNAs [PDF]

, 1929
Digitalitzat per ...
Batey, Robert
core   +1 more source

Associating HIV-1 envelope glycoprotein structures with states on the virus observed by smFRET.

Nature, 2019
The HIV-1 envelope glycoprotein (Env) trimer mediates cell entry and is conformationally dynamic1–8. Imaging by single-molecule fluorescence resonance energy transfer (smFRET) has revealed that, on the surface of intact virions, mature pre-fusion Env ...
Maolin Lu, Xiaochu Ma, Luis R. Castillo-Menendez, J. Gorman, Nirmin Alsahafi, U. Ermel, Daniel S. Terry, Michael J. Chambers, Dongjun Peng, Baoshan Zhang, T. Zhou, N. Reichard, Kevin Wang, Jonathan R. Grover, Brennan P. Carman, M. Gardner, Ivana Nikić-Spiegel, A. Sugawara, J. Arthos, E. Lemke, Amos B. Smith, M. Farzan, C. Abrams, James B. Munro, A. McDermott, A. Finzi, P. Kwong, S. Blanchard, J. Sodroski, W. Mothes   +29 more
semanticscholar   +1 more source

Structure and Functions of NDR1/HIN1‐Like (NHL) Proteins in Plant Development and Response to Environmental Stresses

Plant, Cell &Environment, Volume 48, Issue 8, Page 5897-5908, August 2025.
ABSTRACT The NON‐RACE‐SPECIFIC DISEASE RESISTANCE 1/harpin‐induced 1‐LIKE (NHL) gene family plays pivotal roles, including pathogen resistance, abiotic stress tolerance, and developmental regulation, underscoring their functional versatility in developmental and physiological processes of plants.
Victoria Amato, Shantel Mahalath, Liyuan Zhang, Paul J. Rushton, Qingxi J. Shen   +4 more
wiley   +1 more source

Abstract Conformer Space

Helvetica Chimica Acta, Volume 108, Issue 7, July 2025.
Proteins are intrinsically flexible and thus require an ensemble description. In abstract conformer space, ensemble diversity is easier to assess and the required ensemble size can be established. Abstract Pairwise distance root mean square deviation defines a hyperspace where conformers with similar shape reside close to each other.
Gunnar Jeschke
wiley   +1 more source

Microscopy and spectroscopy approaches to study GPCR structure and function

British Journal of Pharmacology, Volume 182, Issue 14, Page 3090-3108, July 2025.
Abstract The GPCR signalling cascade is a key pathway responsible for the signal transduction of a multitude of physical and chemical stimuli, including light, odorants, neurotransmitters and hormones. Understanding the structural and functional properties of the GPCR cascade requires direct observation of signalling processes in high spatial and ...
Tomáš Fessl, Maria Majellaro, Alexey Bondar   +2 more
wiley   +1 more source

High-throughput smFRET analysis of freely diffusing nucleic acid molecules and associated proteins [PDF]

, 2019
Single-molecule Förster resonance energy transfer (smFRET) is a powerful technique for nanometer-scale studies of single molecules. Solution-based smFRET, in particular, can be used to study equilibrium intra- and intermolecular conformations, binding ...
Chung, SangYoon, Ingargiola, Antonino, Lerner, Eitan, Michalet, X., Segal, Maya, Streets, Aaron, Weiss, S., White, Jonathan A.   +7 more
core  

Arrestin‐centred interactions at the membrane and their conformational determinants

British Journal of Pharmacology, Volume 182, Issue 14, Page 3135-3150, July 2025.
Abstract More than 30 years after their discovery, arrestins are recognised multiprotein scaffolds that play essential roles in G protein‐coupled receptor (GPCR) regulation and signalling. Originally named for their capacity to hinder GPCR coupling to G proteins and facilitate receptor desensitisation, arrestins have emerged as key hubs for a myriad of
Owen Underwood, Raphael Silvanus Haider, Julie Sanchez, Meritxell Canals   +3 more
wiley   +1 more source

\u3cem\u3ePlasmodium falciparum\u3c/em\u3e SSB Tetramer Binds Single-Stranded DNA Only in a Fully Wrapped Mode [PDF]

, 2012
The tetrameric Escherichia coli single-stranded DNA (ssDNA) binding protein (Ec-SSB) functions in DNA metabolism by binding to ssDNA and interacting directly with numerous DNA repair and replication proteins.
Antony, Edwin, Kozlov, Alexander G., Lohman, Timothy M., Nguyen, Binh   +3 more
core   +1 more source

Relevance of G protein‐coupled receptor (GPCR) dynamics for receptor activation, signalling bias and allosteric modulation

British Journal of Pharmacology, Volume 182, Issue 14, Page 3211-3224, July 2025.
Abstract G protein‐coupled receptors (GPCRs) are one of the major drug targets. In recent years, computational drug design for GPCRs has mainly focused on static structures obtained through X‐ray crystallography, cryogenic electron microscopy (cryo‐EM) or in silico modelling as a starting point for virtual screening campaigns. However, GPCRs are highly
Marta Lopez‐Balastegui, Tomasz Maciej Stepniewski, Małgorzata M. Kogut‐Günthel, Antonella Di Pizio, Mette Marie Rosenkilde, Jiafei Mao, Jana Selent   +6 more
wiley   +1 more source