Mechanistic Exploration of Smilax glabra Roxb. in Osteoarthritis: Insights from Network Pharmacology, Molecular Docking, and In Vitro Validation [PDF]
PharmaceuticalsBackground: Arthritis, a debilitating joint disease, remains a significant global health burden. This study uncovers the therapeutic potential of the medicinal plant Smilax glabra Roxb.
Sidra Ilyas +5 more
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Predicting future habitat suitability of Smilax glabra under climate change scenarios [PDF]
Scientific ReportsThe rhizome of Smilax glabra Roxb., known as Smilacis glabrae Rhizoma, is extensively used in Traditional Chinese Medicine for relieving dampness and other health issues. The growth patterns and geographical distribution of S.
Xu Sun +6 more
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Investigation of the molecular mechanism of Smilax glabra Roxb. in treating hypertension based on proteomics and bioinformatics [PDF]
Frontiers in PharmacologyBackgroundSmilax glabra Roxb. (named tufuling in Chinese, SGR) has both medicinal and edible value. SGR has obvious pharmacological activity, especially in anti-inflammation and treating immune system diseases.
Xin Yang +3 more
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Smilax glabra flavonoids ameliorate non-alcoholic steatohepatitis by regulating PKM2-dependent glycolysis and suppressing AIM2 inflammasome activation [PDF]
Frontiers in ImmunologyBackgroundNonalcoholic steatohepatitis (NASH) is a prevalent chronic liver disease characterized by hepatic steatosis, persistent inflammation and progressive liver damage. Smilax glabra flavonoids (SGF), the major bioactive constituents of Smilax glabra
Ziyao Pang +8 more
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The herbal pair of Smilax glabra Roxb. and Ficus hirta Vahl. improves exercise performance by regulating mitochondrial function via the adiponection receptors-mediated AMPK signaling pathway [PDF]
Frontiers in NutritionIntroductionExercise fatigue can significantly impair physical function, while herbal medicines exhibit broad application prospects in anti-fatigue research. The herbal pair of Smilax glabra Roxb. and Ficus hirta Vahl.
Ya-Nan Bao +17 more
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Drug Design, Development and Therapy, 2022 Hao Wu,1,* Yu Wang,1,* Bing Zhang,1,2 Yao-lei Li,1 Zhi-xin Ren,1 Jing-jian Huang,1 Zhi-qi Zhang,1 Zhi-jian Lin,1 Xiao-meng Zhang1 1Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine ...
Bing Zhang +2 more
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Polysaccharide from Smilax glabra Roxb Mitigates Intestinal Mucosal Damage by Therapeutically Restoring the Interactions between Gut Microbiota and Innate Immune Functions. [PDF]
Nutrients, 2023 Smilax glabra Roxb (S. glabra) is a conventional Chinese medicine that is mainly used for the reliability of inflammation. However, bioactive polysaccharides from S. glabra (SGPs) have not been thoroughly investigated.
Abaidullah M +8 more
europepmc +2 more sources
Molecules, 2015 Astilbin, a dihydroflavonol derivative found in many food and medicine plants, exhibited multiple pharmacological functions. In the present study, the ethanol extraction of astilbin from the rhizome of smilax glabra Roxb was optimized by response surface
Chuan-Li Lu +6 more
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Engeletin Targets Mitochondrial Dysfunction to Attenuate Oxidative Stress and Experimental Colitis in Intestinal Epithelial Cells Through AMPK/SIRT1/PGC-1α Signaling [PDF]
AntioxidantsInflammatory bowel disease (IBD), encompassing Crohn’s disease and ulcerative colitis, is characterized by chronic intestinal inflammation and epithelial barrier disruption.
Jing Li +9 more
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Food Chemistry: X, 2022 Smilax glabra Roxb. (SG) is widely used as functional food with various beneficial effects. Fresh SG without processing has been eaten directly for anti-inflammation from ancient China, while the underlying mechanism remains underexplored.
Youjiao Wu +6 more
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