Results 21 to 30 of about 22,074 (160)

Yiqi-Wenyang-Tiaoshen Decoction Reduces Cisplatin-Induced Acute Kidney Injury in Rats Through Autophagy and Apoptosis Signaling Pathways Based on Network Pharmacology and Experimental Validation. [PDF]

Mediators Inflamm
Context The mechanism of Yiqi–Wenyang–Tiaoshen decoction (YWT) in treating cisplatin‐induced acute kidney injury (AKI) remains unknown. Objective This study identifies the key components of YWT and explores its therapeutic potential and mechanisms in a cisplatin‐induced AKI rat model.
Bai Y, Chang Y, Zhang L, Zhou W, Su Y, Zhou J.   +5 more
europepmc   +2 more sources

Optimization of Astilbin Extraction from the Rhizome of Smilax glabra, and Evaluation of Its Anti-Inflammatory Effect and Probable Underlying Mechanism in Lipopolysaccharide-Induced RAW264.7 Macrophages

Molecules, 2015
Astilbin, a dihydroflavonol derivative found in many food and medicine plants, exhibited multiple pharmacological functions. In the present study, the ethanol extraction of astilbin from the rhizome of smilax glabra Roxb was optimized by response surface
Chuan-Li Lu, Yan-Fang Zhu, Meng-Mei Hu, Dong-Mei Wang, Xiao-Jie Xu, Chuan-Jian Lu, Wei Zhu   +6 more
doaj   +2 more sources

Smilax glabra Roxb.: A Review of Its Traditional Usages, Phytochemical Constituents, Pharmacological Properties, and Clinical Applications. [PDF]

Drug Des Devel Ther, 2022
Smilax glabra Roxb. (SGB) is a medicinal plant widely distributed in 17 countries worldwide. It is the primary raw material of the world-famous and best-selling functional food and beneficial tea. SGB was first recorded in Ben Cao Jing Ji Zhu of the Southern and Northern Dynasties (420-589 AD) and was reported for nutritional and medicinal properties ...
Wu H, Wang Y, Zhang B, Li YL, Ren ZX, Huang JJ, Zhang ZQ, Lin ZJ, Zhang XM.   +8 more
europepmc   +4 more sources

Exploring the Potential Mechanism of Smilax Glabra Roxb in Periodontitis Through Network Pharmacology and Molecular Docking. [PDF]

Curr Pharm Des
Introduction: This study aims to explore the potential mechanisms of Smilax Glabra Roxb (SGR) in the treatment of periodontitis using network pharmacology and molecular docking. Methods: The active components and targets of SGR were ...
Hong J, Ma P, Zhang Y, Li N, Zhang P, Tian C, Cao Y, Wang X.   +7 more
europepmc   +3 more sources

Influence of heat processing on the anti-inflammatory activity of fresh Smilax glabra based on PDE4 inhibition

Food Chemistry: X, 2022
Smilax glabra Roxb. (SG) is widely used as functional food with various beneficial effects. Fresh SG without processing has been eaten directly for anti-inflammation from ancient China, while the underlying mechanism remains underexplored.
Youjiao Wu, Lili He, Yi Yang, Zhigang Yan, Zhifeng Zhang, Xiaojun Yao, Pei Luo   +6 more
doaj   +1 more source

<i>Smilax glabra</i> Flavonoids Inhibit AMPK Activation and Induce Ferroptosis in Obesity-Associated Colorectal Cancer. [PDF]

Int J Mol Sci
Smilax glabra flavonoids (SGF), the active components of Smilax glabra Roxb., have been demonstrated to exhibit antioxidant activity and metabolic benefits in obesity, leading us to further explore their antitumor effects in obesity-related colorectal ...
Xu J, Cai Z, Pang Z, Chen J, Zhu K, Wang D, Tu J.   +6 more
europepmc   +2 more sources

Ethyl acetate extract of Smilax glabra Roxb roots and its major active compound astilbin promote osteoblastogenesis in vitro by upregulating bone cell differentiation- associated genes

Asian Pacific Journal of Tropical Biomedicine, 2021
Objective: To investigate the osteoblastogenic activity of the ethyl acetate (EtOAc) extract of Smilax glabra Roxb roots and its major active compound astilbin.
Huyen T.T. Nguyen, Minh T.H. Nguyen, Thu X Nguyen, Quan M Pham, Ha X Nguyen, Phuong T.M. Nguyen   +5 more
doaj   +1 more source

Astilbin from Smilax glabra Roxb. Attenuates Inflammatory Responses in Complete Freund's Adjuvant-Induced Arthritis Rats. [PDF]

Evid Based Complement Alternat Med, 2017
Astilbin, a flavonoid compound, was isolated from the rhizome of Smilax glabra Roxb. (with red cross‐section) grown in Guizhou Province, China. We accessed its effect and potential mechanism on attenuation of the inflammatory response in CFA‐induced AA rats. Our results showed that daily oral administration of astilbin at 5.3 mg/kg reduced joint damage
Dong L, Zhu J, Du H, Nong H, He X, Chen X.   +5 more
europepmc   +4 more sources

Network Pharmacology, Molecular Docking and Dynamics Simulation Reveal the Anti-Colitis Mechanism of <i>Smilax glabra</i> Roxb. [PDF]

Clin Exp Gastroenterol
Yuan Cui,1,2 Jingyi Hu,1 Yanan Li,1 Yiheng Tong,1 Hong Shen1 1Department of Gastroenterology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210001, People’s Republic of China; 2Department of Gastroenterology, Ningxian Second People’s Hospital, Qingyang, 745200, People’s ...
Cui Y, Hu J, Li Y, Tong Y, Shen H.
europepmc   +3 more sources

Corrigendum to "Astilbin from Smilax glabra Roxb. Attenuates Inflammatory Responses in Complete Freund's Adjuvant-Induced Arthritis Rats". [PDF]

Evid Based Complement Alternat Med, 2018
[This corrects the article DOI: 10.1155/2017/8246420.].
Dong L, Zhu J, Du H, Nong H, He X, Chen X.   +5 more
europepmc   +4 more sources