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Pasuchaca (Geranium dielsiaum Knuth): A New Source of Astilbin with Antiglycation Activity [PDF]

Foods
Pasuchaca (Geranium dielsianum Knuth), a traditional Peruvian medicinal plant from the Geraniaceae family used for diabetes management, was investigated for its antiglycative properties.
Guanglei Zuo, Zhaoyang Wu, Hyun-Yong Kim, Jinghui Feng, Soo Kyeong Lee, Yanymee Nimesia Guillen Quispe, Soon Sung Lim   +6 more
doaj   +2 more sources

Mechanistic insights and therapeutic potential of astilbin and apigenin in diabetic cardiomyopathy [PDF]

Heliyon
Diabetic cardiomyopathy (DCM) represents a critical complication of Diabetes mellitus (DM), characterized by structural and functional changes in the myocardium independent of coronary artery disease or hypertension.
Sachin Dhiman, Sanchit Dhankhar, Anjali Garg, Manni Rohilla, Monika Saini, Thakur Gurjeet Singh, Samrat Chauhan, Samy Selim, Soad K. Al Jaouni, Sabina Yasmin, Naseem Begum, Aziza Alshahrani, Mohammad Yousuf Ansari   +12 more
doaj   +2 more sources

The Box–Behnken Design for Optimizing HPLC Separation and Validation of Astilbin in Lysiphyllum strychnifolium Stems [PDF]

Scientifica
The goal of the research was to use BBD, a productive RSM approach, to enhance the HPLC separation and validation of astilbin in Lysiphyllum strychnifolium stems. The percentage of acetonitrile (ACN), flow rate, and temperature were among the independent
Chaowalit Monton, Jirapornchai Suksaeree
doaj   +2 more sources

Component characterization of Smilax glabra Roxb., and its inhibitory activity against Helicobacter pylori through targeted suppression of its secreted urease [PDF]

Frontiers in Cellular and Infection Microbiology
BackgroundSmilax glabra Roxb. (SGR), known as “tufuling” in China, is a medical and edible plant, which has anti-inflammatory, antibacterial and antineoplastic activity. SGR is extensively utilized in the remedy of gastroenteric disorders associated with
Ying Tang, Fan Yang, Xia Wen, Yi Zhou, Rong Tang, Xiuzhi He, Qiang Lu, Cailan Li, Cailan Li, Cailan Li   +9 more
doaj   +2 more sources

Astilbin Alleviates Radiation-Induced Pulmonary Fibrosis via circPRKCE Targeting the TGF-β/Smad7 Pathway to Inhibit Epithelial–Mesenchymal Transition [PDF]

Biomedicines
Purpose: This study aimed to clarify the protective effect of astilbin (AST) on radiation-induced pulmonary fibrosis (RIPF) and explore its underlying molecular mechanism, focusing on non-coding RNAs. Methods: Mouse lung epithelial cells (MLE-12 and TC-1)
Zhiling Shi, Jing Liu, Jing Qin, Xian Liang, Xue Ou, Tingting Zhang, Xueting Yan, Qianxin Hu, Weimei Huang, Kai Hu   +9 more
doaj   +2 more sources

Advances in the chemical constituents, pharmacological activity, and clinical application of Smilacis Glabrae Rhizoma: A review and predictive analysis of quality markers (Q-markers) [PDF]

Heliyon
Smilacis Glabrae Rhizoma (SGR) is recognized in traditional Chinese medicine for its distinctive therapeutic properties and abundant supply. Its phytochemical profile is diverse, encompassing flavonoids, steroids, saccharides, phenolic glycosides ...
Mingxin Guo, Jiaqi Zeng, Zhanle Wang, Ying Shen   +3 more
doaj   +2 more sources

Molecular Insight into the Binding of Astilbin with Human Serum Albumin and Its Effect on Antioxidant Characteristics of Astilbin

Molecules, 2022
Astilbin is a dihydroflavonol glycoside identified in many natural plants and functional food with promising biological activities which is used as an antioxidant in the pharmaceutical and food fields.
Xiangyu Han, Jing Sun, Tianmei Niu, Beibei Mao, Shijie Gao, Pan Zhao, Linlin Sun   +6 more
doaj   +1 more source

Ethyl acetate extract of Smilax glabra Roxb roots and its major active compound astilbin promote osteoblastogenesis in vitro by upregulating bone cell differentiation- associated genes

Asian Pacific Journal of Tropical Biomedicine, 2021
Objective: To investigate the osteoblastogenic activity of the ethyl acetate (EtOAc) extract of Smilax glabra Roxb roots and its major active compound astilbin.
Huyen T.T. Nguyen, Minh T.H. Nguyen, Thu X Nguyen, Quan M Pham, Ha X Nguyen, Phuong T.M. Nguyen   +5 more
doaj   +1 more source

Astilbin Activates the Reactive Oxidative Species/PPARγ Pathway to Suppress Effector CD4+ T Cell Activities via Direct Binding With Cytochrome P450 1B1

Frontiers in Pharmacology, 2022
Astilbin, as a compound of flavonoids, exerts anti-inflammation, antioxidation, and immune-suppression activities. Decreased activation of NF-κB and p38 MAPK and increased activation of SOCS3 and AMPK have been found in astilbin-treated cells.
Shizhen Ding, Shizhen Ding, Guotao Lu, Biying Wang, Jie Xiang, Chunxia Hu, Zhijie Lin, Zhijie Lin, Yanbing Ding, Yanbing Ding, Weiming Xiao, Weiming Xiao, Weiming Xiao, Weijuan Gong, Weijuan Gong, Weijuan Gong, Weijuan Gong   +16 more
doaj   +1 more source

Oral administration of astilbin mitigates acetaminophen-induced acute liver injury in mice by modulating the gut microbiota [PDF]

Acta Pharmacologica Sinica
Yang Q, He WH, Xie L, Chen T, Liu RF, Hu JJ, Guo JY, Tan GZ, Wu FL, Gu P, Chen P, Chen Y.   +11 more
exaly   +2 more sources