Results 151 to 160 of about 55,907 (261)

circPDE4B downregulation triggers GEMIN5‑dependent translational stress response and autophagy to reduce MAPT pathology

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Circular RNAs (circRNAs) are emerging as key regulators of gene expression, synaptic plasticity, and neuronal function in Alzheimer's disease (AD). Here, we characterize the biological actions of circPDE4B, a highly expressed circRNA markedly reduced in AD. METHODS circPDE4B knockdown in neuronal progenitor cells was combined with
Sambhavi Puri, Sophie J. F. van der Spek, Mintao Lin, Zihan Wang, Jacob Porter, Junming Hu, Liyuan Hu, Alejandro N. Rondón‐Ortiz, Alexander Knyshov, Jenna L. Libera, Scott E. Counts, Debomoy K. Lahiri, Julia TCW, Andrew Emili, Xiaoling Zhang, Benjamin Wolozin   +15 more
wiley   +1 more source

RNA-binding proteins TDP-43 and FUS promote R-loop resolution and regulate transcription termination. [PDF]

J Biol Chem
Zhao DY, Nabeel-Shah S, Ni Z, Pu S, Zhong G, Schmitges FW, Braunschweig U, Blencowe BJ, Greenblatt JF.   +8 more
europepmc   +1 more source

Innovations in Herbal Functional Beverages: From Green Formulation and Bioactivity Preservation to Sensory Optimization and Regulatory Safety

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
Herbal‐extract‐enriched beverages are emerging as promising functional foods that combine sensory appeal with health‐promoting bioactives. This review summarizes their formulation in hot and cold beverages, focusing on processing challenges, physicochemical stability, sensory quality, encapsulation strategies, health benefits, safety, and regulatory ...
Farhang Hameed Awlqadr, Syamand Ahmed Qadir, Ammar B. Altemimi, Rawaa H. Tlay, Mohammed N. Saeed, Othman Abdulrahman Mohammed, Tarek Gamal Abedelmaksoud   +6 more
wiley   +1 more source

Differential Neural Dynamics in Psychomotor Retardation and Agitation of Depression. [PDF]

Hum Brain Mapp
Liang Q, Xu Z, Chen S, Lin S, Lin X, Li Y, Zhang Y, Peng B, Hou G, Qiu Y, Northoff G.   +10 more
europepmc   +1 more source

Sustainable Applications of Thymol: Advances in Formulation Technologies, Drug Delivery Systems, and Food Preservation Strategies

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
Thymol is a natural monoterpene with antimicrobial, antioxidant, anti‐inflammatory, and anticancer activities relevant to food and biomedical applications. Its poor solubility and instability can be improved through nanodelivery systems. Thymol also supports sustainable food preservation and active packaging, although further clinical validation and ...
Farhang Hameed Awlqadr, Mohammed N. Saeed, Ammar B. Altemimi, Syamand Ahmed Qadir, Aryan Mahmood Faraj, Othman Abdulrahman Mohammed, Tablo H. Salih, Rawaa H. Tlay, Tarek Gamal Abedelmaksoud   +8 more
wiley   +1 more source

Cerebellar pathology contributes to neurodevelopmental deficits in spinal muscular atrophy. [PDF]

Brain
Gerstner F, Wittig S, Menedo C, Ruwald S, Carlini MJ, Vankova A, Sowoidnich L, Martín-López G, Dreilich V, Alonso-Collado A, Pagiazitis JG, Aousji O, Grzyb C, Smith AK, Yang M, Roselli F, Mentis GZ, Sumner CJ, Pellizzoni L, Simon CM.   +19 more
europepmc   +1 more source

Development of a High‐Sensitivity Electrochemical Biosensor for Domoic Acid and Its Cellular Impact on Human Stem and Neuron‐Like Cells

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
Integrated workflow of domoic acid (DA) detection in seafood using a high‐sensitivity electrochemical biosensor and subsequent evaluation of DA‐induced cellular responses. (A) DA monitoring in seafood: Marine samples (European anchovy and mussels from the Marmara and Black Sea) were collected, extracted using a 1:1 methanol/water mixture, and analyzed ...
Emilia Qomi Ekenel, Yucel Koc, Burcugul Altug, Merve Nur Soykan, Bahar Demir Cevizlidere, Sibel Gunes Bagis, Onur Uysal, Tugba Semerci Sevimli, Murat Sevimli, Ayla Eker Sariboyaci, Huseyin Avci   +10 more
wiley   +1 more source

Spectral dynamic causal modeling of effective connectivity across multiple brain networks in pilot trainees. [PDF]

iScience
Ye L, Zhang Y, Yan D.
europepmc   +1 more source

Gut–Brain Connection: Deciphering Causal Pathways Between Gut Microbiota and Neuroimaging Profiles Through Mendelian Randomization

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
This graphical abstract illustrates the bidirectional causal relationships between gut microbiota and brain network connectivity identified using Mendelian randomization analysis. Genome‐wide association study data from the MiBioGen consortium (gut microbiota) and the UK Biobank (brain imaging‐derived phenotypes across seven resting‐state networks ...
Yule Zeng, Longtao Yang, Hui Liu, Hongchun Liao, Yingxia Zhou, Jun Liu   +5 more
wiley   +1 more source

Changes in the cortical GABAergic inhibitory system in a Spinal Muscular Atrophy mouse model. [PDF]

Cell Death Dis
Menduti G, Ferrini F, Caretto A, Hassan A, di Vito R, Beltrando G, Marnetto D, Usiello A, Di Cunto F, Boido M, Vercelli A.   +10 more
europepmc   +1 more source