Adverse Events of Saffron (Crocus sativus L.): Systematic Review of Current Evidence
ABSTRACT Background Crocus sativus L., commonly known as saffron, is a widely used spice with a rich history of culinary and medicinal applications. This systematic review aims to compile human data from studies on monopreparations of C. sativus, including stigma powder and other extracts, to evaluate their safety.
Fatemeh Sadat Hasheminasab +3 more
wiley +1 more source
Distinct neurologic state in patients with traumatic brain injury and hemorrhagic stroke during the stage of acute disorders of consciousness and the correlation with the neurological prognosis: A multi-modal PET/rs-fMRI study. [PDF]
Yu D +17 more
europepmc +1 more source
ABSTRACT Purpose Functional MRI (fMRI) in awake rodents presents countless valuable opportunities for researchers to probe questions that may not be accessible through anesthetized models, such as voluntary locomotion. The commonly used echo planar imaging (EPI) sequence is highly sensitive to motion that occurs even outside of the imaging plane ...
Lauren Daley +3 more
wiley +1 more source
Lymphoid Organ Architecture and Hematopoiesis Disruption in Spinal Muscular Atrophy: Therapeutic Rescue by SMN Restoration. [PDF]
Guillamón P +13 more
europepmc +1 more source
ABSTRACT Introduction/Aims Previous studies of children with spinal muscular atrophy (SMA) have focused on the ulnar and median nerves, while lower‐limb and proximal motor nerves remain insufficiently characterized. This study aimed to evaluate compound muscle action potential (CMAP) amplitudes in upper‐ and lower‐limb motor nerves in children with SMA
Ruidi Sun +8 more
wiley +1 more source
Fibro-adipogenic progenitor cells from murine SMA muscles are intrinsically adipogenic. [PDF]
Luo YE +5 more
europepmc +1 more source
Abstract Objectives Evaluate the association of plating strategies with hardware removal and operative time, after adjusting for relevant clinical variables. Study Design Retrospective Review. Setting Multiple Academic Medical Centers. Methods Patients undergoing osseous free flap reconstruction stratified based on the plating strategy [conventional ...
Craig A. Bollig +19 more
wiley +1 more source
Elevation in network dynamics amplifies amyloid-dependent tau pathology. [PDF]
Li J +27 more
europepmc +1 more source
Ligand‐driven modulation of chaperone–cochaperone networks shapes proteostasis outcomes
Abstract Protein homeostasis depends on a delicate interplay between folding and degradation, orchestrated by molecular chaperones. Among them, Hsp90 is a central hub, regulating nearly 10% of the proteome through ATP‐driven conformational cycles and selective interactions with cochaperones.
Andrea Magni +9 more
wiley +1 more source
SMN1 variants identified by false-positive SMA newborn screening tests: Therapeutic hurdles and functional and epidemiological solutions. [PDF]
Wirth B +14 more
europepmc +1 more source

