Results 31 to 40 of about 55,907 (261)

Survival motor neuron deficiency slows myoblast fusion through reduced myomaker and myomixer expression

Journal of Cachexia, Sarcopenia and Muscle, 2021
Background Spinal muscular atrophy is an inherited neurodegenerative disease caused by insufficient levels of the survival motor neuron (SMN) protein. Recently approved treatments aimed at increasing SMN protein levels have dramatically improved patient ...
Nikki M. McCormack, Eric Villalón, Coralie Viollet, Anthony R. Soltis, Clifton L. Dalgard, Christian L. Lorson, Barrington G. Burnett   +6 more
doaj   +1 more source

Risk of Second Malignant Neoplasm in Familial Non-Medullary Thyroid Cancer Patients

Frontiers in Endocrinology, 2022
IntroductionSurvival rates in patients with non-medullary thyroid carcinoma (NMTC) are high, increasing the possibility to develop a second malignant neoplasm (SMN).
Marco Capezzone, Alfonso Sagnella, Silvia Cantara, Noemi Fralassi, Fabio Maino, Raffaella Forleo, Lucia Brilli, Tania Pilli, Alessandra Cartocci, Maria Grazia Castagna   +9 more
doaj   +1 more source

Enhanced expression of the central survival of motor neuron (SMN) protein during the pathogenesis of osteoarthritis [PDF]

, 2015
The identification of new components implicated in the pathogenesis of osteoarthritis (OA) might improve our understanding of the disease process.
Cucchiarini, Magali, Madry, Henning, Terwilliger, Ernest F   +2 more
core   +1 more source

All-gas-phase synthesis of UiO-66 through modulated atomic layer deposition

Nature Communications, 2016
Thin films of metal-organic frameworks (MOFs) are promising for catalysis, gas storage, and microelectronics. Here, the authors introduce a vapour-phase synthesis of UiO-66 thin films, beginning with modulated atomic layer deposition of porous, amorphous
Kristian Blindheim Lausund, Ola Nilsen
doaj   +1 more source

Survival motor neuron protein regulates oxidative stress and inflammatory response in microglia of the spinal cord in spinal muscular atrophy

Journal of Pharmacological Sciences, 2020
The deficiency of survival motor neuron (SMN) protein can result in the onset of spinal muscular atrophy (SMA), an autosomal recessive disorder characterized by a progressive loss of motor neurons and skeletal muscle atrophy. The mechanism underlying SMA
Shiori Ando, Daiki Osanai, Kei Takahashi, Shinsuke Nakamura, Masamitsu Shimazawa, Hideaki Hara   +5 more
doaj   +1 more source

Macromolecular complexes: SMN — the master assembler [PDF]

Current Biology, 2001
Recent studies indicate that the protein affected in spinal muscular atrophy, SMN, plays a role in the assembly of a number of macromolecular complexes that function in the nucleus, interacting with its partner proteins via their arginine- and glycine-rich domains.
Terns, Michael P, Terns, Rebecca M
openaire   +2 more sources

Proton beam therapy in paediatric cancer: Anticipating the opening of the Australian Bragg Centre for Proton Therapy and Research

Journal of Medical Imaging and Radiation Oncology, EarlyView., 2023
Summary Proton Beam Therapy (PBT) has the potential to improve paediatric cancer care by reducing radiation exposure and thus long‐term toxicities. Ethical concerns and debates surrounding the treatment, such as eligibility and accessibility, are ongoing in Australia. The Australian Bragg Centre for Proton Therapy and Research (ABCPTR) (named after Sir
Jeremy Khong, Hui Tee, Peter Gorayski, Hien Le, Michael Penniment, Sophie Jessop, Jordan Hansford, Melanie Penfold, Julia Green, Kelly Skelton, Frank Saran   +10 more
wiley   +1 more source

Review of key causes and sources for N2O emmisions and NO3-leaching from organic arable crop rotations [PDF]

, 2018
. The emissions of nitrous oxide (N2O) and leaching of nitrate (NO3) have considerable negative impacts on climate and the environment. Although these environmental burdens are on average less per unit area in organic than in non-organic production, they
Doltra, Jordi, Frøseth, Randi Berland, Hansen, Sissel, Krauss, Maike, Nadeem, Shahid, Olesen, Jørgen E., Pappa, Valentini, Radzikowski, Pawel, Stalenga, Jarosław, Stenberg, Maria, Torp, Torfinn, Watson, Christine   +11 more
core   +1 more source

Biocompatible organic–inorganic hybrid materials based on nucleobases and titanium developed by molecular layer deposition

Beilstein Journal of Nanotechnology, 2019
We have constructed thin films of organic–inorganic hybrid character by combining titanium tetra-isopropoxide (TTIP) and the nucleobases thymine, uracil or adenine using the molecular layer deposition (MLD) approach.
Leva Momtazi, Henrik H. Sønsteby, Ola Nilsen   +2 more
doaj   +1 more source

The TUDOR domain of SMN is an H3K79 me1 histone mark reader

Life Science Alliance, 2023
The survival of motor neuron (SMN) protein is depleted in spinal muscular atrophy (SMA) pathology and herein defined as the first reader of histone H3 mono-methylated on lysine 79 through its central TUDOR domain.
Olivier Binda, Aimé Boris Kimenyi Ishimwe, Maxime Galloy, Karine Jacquet, Armelle Corpet, Amélie Fradet-Turcotte, Jocelyn Côté, Patrick Lomonte   +7 more
doaj   +1 more source