Results 41 to 50 of about 55,907 (261)
Neurobiology of Disease, 2009 Mutations in the ubiquitously expressed survival motor neuron 1 (SMN1) and superoxide dismutase 1 (SOD1) genes are selectively lethal to motor neurons in spinal muscular atrophy (SMA) and familial amyotrophic lateral sclerosis (ALS), respectively ...
Bradley J. Turner +3 more
doaj +1 more source
Evaluation of peripheral blood mononuclear cell processing and analysis for Survival Motor Neuron protein. [PDF]
PLoS ONE, 2012 OBJECTIVES: Survival Motor Neuron (SMN) protein levels may become key pharmacodynamic (PD) markers in spinal muscular atrophy (SMA) clinical trials. SMN protein in peripheral blood mononuclear cells (PBMCs) can be quantified for trials using an enzyme ...
Dione T Kobayashi +9 more
doaj +1 more source
Twisted phase of the orbital-dominant ferromagnet SmN in a GdN/SmN heterostructure [PDF]
Physical Review B, 2015 The strong spin-orbit interaction in the rare-earth elements ensures that even within a ferromagnetic state there is a substantial orbital contribution to the ferromagnetic moment, in contrast to more familiar transition metal systems, where the orbital moment is usually quenched.
McNulty, James +9 more
openaire +3 more sources
Bayesian modelling of skewness and kurtosis with two-piece scale and shape distributions [PDF]
, 2015 We formalise and generalise the definition of the family of univariate double two--piece distributions, obtained by using a density--based transformation of unimodal symmetric continuous distributions with a shape parameter.
Rubio, F. J., Steel, M. F. J.
core +2 more sources
Protective effects of silymarin on methotrexate-induced damages in rat testes
Brazilian Journal of Pharmaceutical Sciences, 2018 The present study aimed to investigate the protective effects of silymarin (SMN), an antioxidant, on methotrexate (MTX)-induced damage in rat testes. Thirty-two Wistar albino rats were divided into four groups (n = 8): control, MTX (20 mg/kg, i.p.
Turan Yaman +5 more
doaj +1 more source
Disruption of SMN function by ectopic expression of the human SMN gene in Drosophila [PDF]
FEBS Letters, 2000 Spinal muscular atrophy is a neurodegenerative disorder caused by mutations or deletions in the survival motor neuron (SMN) gene. We have cloned the Drosophila ortholog of SMN (DmSMN) and disrupted its function by ectopically expressing human SMN. This leads to pupal lethality caused by a dominant‐negative effect, whereby human SMN may bind endogenous ...
Miguel-Aliaga, I +3 more
openaire +2 more sources
Ramond-Ramond gauge fields in superspace with manifest T-duality
, 2015 A superspace with manifest T-duality including Ramond-Ramond gauge fields is presented. The superspace is defined by the double nondegenerate super-Poincare algebras where Ramond-Ramond charges are introduced by central extension. This formalism allows a
Hatsuda, Machiko +2 more
core +1 more source
SMA-causing missense mutations in survival motor neuron (Smn) display a wide range of phenotypes when modeled in Drosophila. [PDF]
PLoS Genetics, 2014 Mutations in the human survival motor neuron 1 (SMN) gene are the primary cause of spinal muscular atrophy (SMA), a devastating neuromuscular disorder.
Kavita Praveen +6 more
doaj +1 more source
Pedestrian Trajectory Prediction with Structured Memory Hierarchies
, 2018 This paper presents a novel framework for human trajectory prediction based on multimodal data (video and radar). Motivated by recent neuroscience discoveries, we propose incorporating a structured memory component in the human trajectory prediction ...
A Roy +10 more
core +1 more source
Modeling spinal muscular atrophy in Drosophila.
PLoS ONE, 2008 Spinal Muscular Atrophy (SMA), a recessive hereditary neurodegenerative disease in humans, has been linked to mutations in the survival motor neuron (SMN) gene. SMA patients display early onset lethality coupled with motor neuron loss and skeletal muscle
Howard Chia-Hao Chang +10 more
doaj +1 more source