Results 171 to 180 of about 5,400 (185)

Structure of a Key Intermediate of the SMN Complex Reveals Gemin2's Crucial Function in snRNP Assembly

Cell, 2011
SummaryThe SMN complex mediates the assembly of heptameric Sm protein rings on small nuclear RNAs (snRNAs), which are essential for snRNP function.
Rundong Zhang, Byung Ran So, Pilong Li
exaly   +2 more sources

An Assembly Chaperone Collaborates with the SMN Complex to Generate Spliceosomal SnRNPs

Cell, 2008
SummarySpliceosomal small nuclear ribonucleoproteins (snRNPs) are essential components of the nuclear pre-mRNA processing machinery. A hallmark of these particles is a ring-shaped core domain generated by the binding of Sm proteins onto snRNA.
Ashwin Chari, Monika M Golas, Bjoern Sander   +2 more
exaly   +3 more sources

Some of the next articles are maybe not open access.

Related searches:

The exonuclease ISG20 mainly localizes in the nucleolus and the Cajal (Coiled) bodies and is associated with nuclear SMN protein‐containing complexes

Journal of Cellular Biochemistry, 2006
AbstractWe have previously shown that ISG20, an interferon (IFN)‐induced gene, encodes a 3′ to 5′ exoribonuclease member of the DEDD superfamily of exonucleases. ISG20 specifically degrades single‐stranded RNA. In this report, using immunofluorescence analysis, we demonstrate that in addition to a diffuse cytoplasmic and nucleoplasmic localization, the
Espert, Lucile, Eldin, Patrick, Gongora, Céline, Bayard, Bernard, Harper, Francis, Chelbi-Alix, Mounira, Bertrand, Edouard, Degols, Geneviève, Mechti, Nadir   +8 more
openaire   +2 more sources

A role for complexes of survival of motor neurons (SMN) protein with gemins and profilin in neurite-like cytoplasmic extensions of cultured nerve cells

Experimental Cell Research, 2005
Spinal muscular atrophy (SMA) is caused by reduced levels of SMN (survival of motor neurons protein) and consequent loss of motor neurons. SMN is involved in snRNP transport and nuclear RNA splicing, but axonal transport of SMN has also been shown to occur in motor neurons. SMN also binds to the small actin-binding protein, profilin.
Aarti, Sharma, Anja, Lambrechts, Le Thi, Hao, Thanh T, Le, Caroline A, Sewry, Christophe, Ampe, Arthur H M, Burghes, Glenn E, Morris   +7 more
openaire   +2 more sources

SMN: understanding a complex protein complex and its role in disease

Clinical Genetics, 1999
openaire   +1 more source

Study of the protein-protein interactions between the SMN complex and the factors required for box C/D and H/ACA RNP assembly

2012
Les particules ribonucléoprotéiques (RNP) à boîtes C/D et H/ACA sont impliquées dans la maturation des UsnRNA et des précurseurs des ARNr. L'assemblage de ces RNP dans les cellules est un processus complexe faisant intervenir de nombreux facteurs cellulaires dont NUFIP, commun aux deux RNP, et NAF1, spécifique aux RNP à boîtes H/ACA.
openaire   +1 more source

TOR signaling regulates liquid phase separation of the SMN complex governing snRNP biogenesis

Cell Reports, 2021
Jürgen Reymann, Holger Erfle, Henrik Daub   +2 more
exaly  

Functional mammalian spliceosomal complex E contains SMN complex proteins in addition to U1 and U2 snRNPs

Nucleic Acids Research, 2012
Evgeny M Makarov, Nicholas Owen, Andrew R Bottrill   +2 more
exaly  

The SMN complex

Experimental Cell Research, 2004
Gideon Dreyfuss
exaly  

The SMN complex, an assemblyosome of ribonucleoproteins

Current Opinion in Cell Biology, 2002
Severine Massenet
exaly