Results 91 to 100 of about 920,258 (356)

Role and regulation of Abelson tyrosine kinase in Crk-associated substrate/profilin-1 interaction and airway smooth muscle contraction

Respiratory Research, 2018
Background Airway smooth muscle contraction is critical for maintenance of appropriate airway tone, and has been implicated in asthma pathogenesis. Smooth muscle contraction requires an “engine” (myosin activation) and a “transmission system” (actin ...
Yinna Wang, Alyssa C. Rezey, Ruping Wang, Dale D. Tang   +3 more
doaj   +1 more source

Involvement of STAT3 in Bladder Smooth Muscle Hypertrophy Following Bladder Outlet Obstruction [PDF]

, 2006
We examined the involvement of the signal transducer and activator of transcription 3 (STAT3) in bladder outlet obstruction (BOO)-induced bladder smooth muscle hypertrophy using a rat in vivo and in vitro study.
Asanuma, Masato, Fujita, Osamu, Kumon, Hiromi, Miyazaki, Ikuko, Ogawa, Norio, Yokoyama, Teruhiko   +5 more
core   +1 more source

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

Assessment of a novel, capsid-modified adenovirus with an improved vascular gene transfer profile [PDF]

, 2013
<p>Background: Cardiovascular disorders, including coronary artery bypass graft failure and in-stent restenosis remain significant opportunities for the advancement of novel therapeutics that target neointimal hyperplasia, a characteristic of both ...
AA Soyombo, AC Bradshaw, AC Bradshaw, AF Merrick, AH Baker, AL Parker, AL Parker, Alan L Parker, Andrew H Baker, Angela C Bradshaw, Audrey F Wright, B Vigl, C-C Liang, Christian Delles, DM Roberts, F Sakurai, F Vigant, K Doronin, Katie M White, KD Newman, M Hedman, M Hedman, M Jessup, MC Sprangers, MD Rekhter, MJE Havenga, MM Zanone, MO Hilutnen, N Inoue, O Kalyuzhniy, P Lemarchand, R Alba, R Alba, R Vogels, Raul Alba, RD Lopes, Robert A McDonald, RR Bradley, S Ishii, S Kuriyama, SA Nicklin, SD Carson, SJ George, SJ George, SM Sumida, SN Waddington, TD Henry, TW Johnson   +47 more
core   +2 more sources

Downregulation of sST2, a decoy receptor for interleukin‐33, enhances subcutaneous tumor growth in murine pancreatic cancer cells

FEBS Open Bio, EarlyView.
Subcutaneous implantation of murine Panc02 pancreatic cancer cells depleted of sST2, a soluble decoy receptor for the proinflammatory interleukin‐33 (IL‐33), leads to a decreased number of GLUT4‐positive cancer‐associated adipocytes, reduced levels of the anti‐inflammatory molecule adiponectin, increased phosphorylation of IκBα, elevated Cxcl3 ...
Miho Akimoto, Nobuko Koshikawa, Takao Morinaga, Mimi Tamamori‐Adachi, Atsushi Takatori, Keizo Takenaga   +5 more
wiley   +1 more source

Identification and Initial Functional Characterization of a Human Vascular Cell-Enriched Long Noncoding RNA [PDF]

, 2014
OBJECTIVE: Long noncoding RNAs (lncRNAs) represent a rapidly growing class of RNA genes with functions related primarily to transcriptional and post-transcriptional control of gene expression. There is a paucity of information about lncRNA expression and
Bell, R. D., Bergmann, J. H., Cowan, S. L., Han, Y., Lin, M., Long, X., Miano, J. M., Nanda, V., Spector, D. L., Zheng, D., Zhou, Q.   +10 more
core   +1 more source

The impact of Hnrnpl deficiency on transcriptional patterns of developing muscle cells

FEBS Open Bio, EarlyView.
We performed nanopore whole‐transcriptome sequencing comparing RNA from Hnrnpl‐knockdown versus control C2C12 myoblasts to investigate the contributions of Hnrnpl to muscle development. Our results indicate that Hnrnpl regulates the expression of genes involved with Notch signaling and skeletal muscle, particularly splicing patterns of specific muscle ...
Hannah R. Littel, Mekala Gunasekaran, Audrey L. Daugherty, Natalya M. Wells, Johnnie Turner, Christine C. Bruels, Christina A. Pacak, Isabelle Draper, Peter B. Kang   +8 more
wiley   +1 more source

MicroRNA26 attenuates vascular smooth muscle maturation via endothelial BMP signalling.

PLoS Genetics, 2019
As small regulatory transcripts, microRNAs (miRs) act as genetic 'fine tuners' of posttranscriptional events, and as genetic switches to promote phenotypic switching. The miR miR26a targets the BMP signalling effector, smad1.
Charlene Watterston, Lei Zeng, Abidemi Onabadejo, Sarah J Childs   +3 more
doaj   +1 more source

Cyclic Mechanical Stretch Induced Smooth Muscle Cell Changes in Cerebral Aneurysm Progress by Reducing Collagen Type IV and Collagen Type VI Levels

Cellular Physiology and Biochemistry, 2018
Background/Aims: Cerebral aneurysm growth is characterized by continuous structural weakness of local smooth muscle cells, though the mechanism is unclear.
Peixi Liu, Yaying Song, Yingjie Zhou, Yingjun Liu, Tianming Qiu, Qingzhu An, Jianping Song, Peiliang Li, Yuan Shi, Sichen Li, Kai Quan, Guo-Yuan Yang, Wei Zhu   +12 more
doaj   +1 more source

CREB depletion in smooth muscle cells promotes medial thickening, adventitial fibrosis and elicits pulmonary hypertension

Pulmonary Circulation, 2020
Levels of the cAMP-responsive transcription factor, CREB, are reduced in medial smooth muscle cells in remodeled pulmonary arteries from hypertensive calves and rats with chronic hypoxia-induced pulmonary hypertension.
Chrystelle V. Garat, Susan M. Majka, Timothy M. Sullivan, Joseph T. Crossno, Jane E.B. Reusch, Dwight J. Klemm   +5 more
doaj   +1 more source