Results 61 to 70 of about 920,258 (356)

Transcription factor GATA6 promotes migration of human coronary artery smooth muscle cells in vitro

Frontiers in Physiology, 2022
Vascular smooth muscle cell plasticity plays a pivotal role in the pathophysiology of vascular diseases. Despite compelling evidence demonstrating the importance of transcription factor GATA6 in vascular smooth muscle, the functional role of GATA6 ...
Azra Alajbegovic, Fatima Daoud, Fatima Daoud, Neserin Ali, Katarzyna Kawka, Johan Holmberg, Sebastian Albinsson   +6 more
doaj   +1 more source

Calcium Signaling in Smooth Muscle [PDF]

Cold Spring Harbor Perspectives in Biology, 2011
Changes in intracellular Ca(2+) are central to the function of smooth muscle, which lines the walls of all hollow organs. These changes take a variety of forms, from sustained, cell-wide increases to temporally varying, localized changes. The nature of the Ca(2+) signal is a reflection of the source of Ca(2+) (extracellular or intracellular) and the ...
Nelson, Mark, Hill-Eubanks, David C., Werner, Matthias E., Heppner, Thomas J., Nelson, Mark T.   +4 more
openaire   +3 more sources

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

Transcriptional profiling reveals extraordinary diversity among skeletal muscle tissues [PDF]

, 2018
Skeletal muscle comprises a family of diverse tissues with highly specialized functions. Many acquired diseases, including HIV and COPD, affect specific muscles while sparing others.
Andrade, Francisco, Douglas, Collin M, Esser, Karyn A, Gong, Ming C, Gutierrez-Monreal, Miguel A, Hoffmann, Christy, Hughes, Laura D, Hughes, Michael E, Lahens, Nicholas F, Lewis, Scott A, Li, Jiajia, Riley, Lance A, Terry, Erin E, Wallace, Matthew J, Zhang, Xiping   +14 more
core   +4 more sources

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

α-Smooth Muscle Actin and ACTA2 Gene Expressions in Vasculopathies

Brazilian Journal of Cardiovascular Surgery, 2015
α-smooth muscle actin, encoded by ACTA2 gene, is an isoform of the vascular smooth muscle actins, typically expressed in the vascular smooth muscle cells contributing to vascular motility and contraction. ACTA2 gene mutations cause a diversity of diffuse
Shi-Min Yuan
doaj   +1 more source

Intestinal smooth muscle aberrations in pancreatic cancer patients with sarcopenia

JCSM Rapid Communications, 2021
Background Cancer cachexia is characterized by impaired function of skeletal and cardiac muscle. Smooth muscle is abundantly present in the body and critical for the function of the gastrointestinal tract.
Rianne D.W. Vaes, Tessa T.J. Welbers, David P.J. vanDijk, Dorit Rennspiess, Axel zur Hausen, Steven W.M. Olde Damink, Sander S. Rensen   +6 more
doaj   +1 more source

The Anatomic Features of Müller’s Muscle: A Histology Study in Chinese

Plastic and Reconstructive Surgery, Global Open, 2021
Background:. The purpose of this article is to clarify the character of Müller’s muscle in Chinese specimens. Methods:. Ten upper eyelids of 10 formalin-fixed Chinese cadavers (9 elderly people, from 68 to 86 years of age; 1 male child, 10 years old ...
Minchen Zhang, BS, Rong Zhou, BS, Jun Wu, PhD, Lulu Chen, PhD, Zijian Ren, PhD, Weicheng Gao, MD   +5 more
doaj   +1 more source

Unique Contractile and Structural Protein Expression in Dog Ileal Inner Circular Smooth Muscle [PDF]

, 2009
This study was designed to test the hypothesis that there is heterogeneous expression of contractile and structural proteins between the smooth muscle cells (SMCs) in the inner and outer circular muscle (ICM and OCM) layers of the ileum ...
Eddinger, Thomas J.
core   +1 more source

Forkhead box F2 Regulation of Platelet-Derived Growth Factor and myocardin/Serum Response Factor Signaling is Essential for Intestinal Development [PDF]

, 2015
Alterations in the forkhead box F2 gene expression have been reported in numerous pathologies, and Foxf2−/− mice are perinatal lethal with multiple malformations; however, molecular mechanisms pertaining to Foxf2 signaling are severely lacking.
Bolte, Craig, Herring, B. Paul, Hoggatt, April, Kalin, Tanya V., Kalinichenko, Vladimir V., Pradhan, Arun, Ren, Xiaomeng, Tomley, Tatiana, Ustiyan, Vladimir   +8 more
core   +1 more source