Results 281 to 290 of about 2,656,785 (305)

Critical care management of chimeric antigen receptor T‐cell therapy recipients

Ca-A Cancer Journal for Clinicians, 2022
Alexander Shimabukuro-Vornhagen, Boris Böll, Peter Schellongowski   +2 more
exaly  

Chimeric antigen receptor T‐cell therapy in multiple myeloma: A comprehensive review of current data and implications for clinical practice

Ca-A Cancer Journal for Clinicians, 2023
Rujul Parikh, Sagar Lonial
exaly  

Synthesis, antitumoral activity, and in silico studies on Smoothened receptor of new 2,6,9-trisubstituted purine derivatives

Journal of Molecular Structure
C. Espinosa-Bustos, A. M. Zárate, A. Castro-Álvarez, Simón Guerrero, Marcelo J. Kogan, Cristian O Salas   +5 more
semanticscholar   +1 more source

Resistance to Hedgehog inhibitor through Smoothened receptor mutation in basal cell carcinoma.

2013
The inappropriate activation of Hedgehog (Hh) pathway is involved in the pathogenesis of skin basal cell carcinoma (BCC). Loss of function of the transmembrane receptor Patched (PTCH1), or gain of function of the Smoothened (SMO), Sonic Hh (SHH), and GLI family transcription factors can be ligand-independent oncogenic drivers of this disease.
Bossi, Paolo, Perrone, Federica, Cortellazzi, Barbara, Licitra, Lisa, Dal Col, Valentina, LAURINI, ERIK, FERMEGLIA, MAURIZIO, PRICL, SABRINA   +7 more
openaire   +2 more sources

Molecular Modelling of Berberine Derivatives as Inhibitors of Human Smoothened Receptor and Hedgehog Signalling Pathway Using a Newly Developed Algorithm on Anti-Cancer Drugs.

Recent Patents on Anti-Cancer Drug Discovery, 2017
Parham Jabbarzadeh Kaboli, M. Bazrafkan, P. Ismail, K. Ling   +3 more
semanticscholar   +1 more source

An In Silico Study on Withania somnifera Bioactives and Curcumin Analogs as Potential Inducers of Smoothened (Smo) Receptor of Sonic Hedgehog (SHH) Pathway to Promote Oligodendrogenesis

Molecular Neurobiology
Shrey Dwivedi, Shristi Modanwal, Sneha Ranjan, Ashutosh Mishra, Nidhi Mishra, Sangeeta Singh   +5 more
semanticscholar   +1 more source

Development of a concise, asymmetric synthesis of a smoothened receptor (SMO) inhibitor: enzymatic transamination of a 4-piperidinone with dynamic kinetic resolution.

Organic Letters, 2014
Zhihui Peng, J. W. Wong, E. Hansen, Angela L. A. Puchlopek-Dermenci, Hugh J. Clarke   +4 more
semanticscholar   +1 more source

Molecular modeling study on the dynamical structural features of human smoothened receptor and binding mechanism of antagonist LY2940680 by metadynamics simulation and free energy calculation.

Biochimica et Biophysica Acta, 2014
Qifeng Bai, Yulin Shen, N. Jin, Huanxiang Liu, X. Yao   +4 more
semanticscholar   +1 more source

The Drosophila smoothened Gene Encodes a Seven-Pass Membrane Protein, a Putative Receptor for the Hedgehog Signal

Cell, 1996
Markus Noll
exaly  

Structural basis of Smoothened regulation by its extracellular domains

Nature, 2016
Eamon F X Byrne, Ria Sircar, Paul S Miller   +2 more
exaly