Results 271 to 280 of about 2,656,785 (305)
Some of the next articles are maybe not open access.
Attenuation of early liver fibrosis by pharmacological inhibition of smoothened receptor signaling
Journal of Drug Targeting, 2012Hedgehog (Hh) signaling is involved in the pathogenesis of liver fibrosis. It has been previously shown that Hh-inhibitor cyclopamine (CYA) can reduce liver fibrosis in rats. However, CYA is not stable in vivo, which limits its clinical application.
Akshay Pratap +6 more
semanticscholar +3 more sources
Journal of Pharmacology and Pharmacotherapeutics, 2019
Aim: To investigate the myocardial preconditioning potential of hedgehog activator smoothened (SMO) receptor agonist purmorphamine (PUR) against ischemia-reperfusion (I/R) injury in deoxycortisone acetate (DOCA) salt-induced hypertensive rat heart ...
Himanshi Khera, Anupam Awasthi, S. Mehan
semanticscholar +1 more source
Aim: To investigate the myocardial preconditioning potential of hedgehog activator smoothened (SMO) receptor agonist purmorphamine (PUR) against ischemia-reperfusion (I/R) injury in deoxycortisone acetate (DOCA) salt-induced hypertensive rat heart ...
Himanshi Khera, Anupam Awasthi, S. Mehan
semanticscholar +1 more source
Neurological Research, 2019
Objectives: To investigate the effect of purmorphamine (PUR), a Shh co-receptor Smoothened (Smo) agonist, on postoperative cognitive dysfunction (POCD) rat models.
Pei Li +6 more
semanticscholar +1 more source
Objectives: To investigate the effect of purmorphamine (PUR), a Shh co-receptor Smoothened (Smo) agonist, on postoperative cognitive dysfunction (POCD) rat models.
Pei Li +6 more
semanticscholar +1 more source
Three-Dimensional Structure of the Smoothened Receptor: Implications for Drug Discovery
, 2014The recently described high resolution three-dimensional structures of the transmembrane and the extracellular domains of the human Smoothened (Smo) receptor higlight both conserved and unique structural features of this G protein-coupled receptor.
D. Rognan, I. Mus-Veteau
semanticscholar +2 more sources
Smoothened receptor as a novel target for remyelination therapies
2021Multiple Sclerosis (MS) is an autoimmune demyelinating disease of unknown aetiology, causing neurodegeneration in the Central Nervous System (CNS). Although the spontaneous capacity of myelin to regenerate can restore neuronal function, during MS progression, the instauration of an inflammatory microenvironment limits oligodendrocyte precursor cells ...
openaire +2 more sources
[Structure of the Smoothened receptor].
Medecine sciences : M/S, 2014The Smoothened (Smo) receptor is a major component involved in signal transduction of the Hedgehog (Hh) morphogens both during embryogenesis and in the adult. Smo antagonists represent a promi-sing alternative for the treatment of cancers linked to abnormal Hh signalling.
Martial, Ruat +3 more
openaire +1 more source
The seven-transmembrane receptor Smoothened cell-autonomously induces multiple ventral cell types
Nature Neuroscience, 2000Sonic Hedgehog (Shh) is a secreted protein that controls cell fate and mitogenesis in the developing nervous system. Here we show that a constitutively active form of Smoothened (Smo-M2) mimics concentration-dependent actions of Shh in the developing neural tube, including activation of ventral marker genes (HNF3beta, patched, Nkx2.2, netrin-1 ...
M, Hynes +6 more
openaire +2 more sources
Pharmacological and structural studies on the hedgehog pathway receptor smoothened
2023The Frizzled-class G protein-coupled receptor Smoothened (SMO) is an essential component of the Hedgehog (HH) signalling pathway, which is of paramount importance to developmental processes of bilaterians. Dysregulation of HH signalling has been implicated in multiple pathophysiological processes in adult organisms, such as cancer development.
openaire +1 more source
Sonidegib phosphate: Smoothened (SMO) receptor antagonist oncolytic
Drugs of the Future, 2014null Salati, M., null Stathis, A.
openaire +1 more source