Results 61 to 70 of about 4,345,331 (321)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Injury Prevention Indicators for Inuit Children and Youth

, 2010
First Nations and Inuit children and youth indicators are important tools to influence policy and to measure community‐specific aspects of health and wellness in a First Nations context.
First Nations and Inuit Children and Youth Injury Indicators Working Group, Pike, Ian, 1958-   +1 more
core   +2 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Earnings quality and type of earnings management in non-stressed and stressed companies [PDF]

Accounting
This paper examines the relationship between earnings management and earnings quality in two countries (93 companies from Tehran Stock Exchange and 92 companies from Saudi Arabia Stock Exchange) for the period (2013-2022 Tehran) and (2014-2023
Ali al-Naffakh, Yaqdan Wahb, Ahmed Al-Kafashi, Mohammed Shlaka, Israa Al-Dhalimi   +4 more
doaj   +1 more source

Quality Assurance Indicators of Long-Term Care in European Countries. ENEPRI Research Report No. 110, April 2012 [PDF]

, 2012
This study reports on the quality indicators that were collected by the ANCIEN project partners in each country considered in Work Package 5 (Quality in Long-Term Care).
Casanova, Georgia, Dandi, Roberto
core  

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

The effect of gravity on hand spatio-temporal kinematic features during functional movements.

PLoS ONE
Understanding the impact of gravity on daily upper-limb movements is crucial for comprehending upper-limb impairments. This study investigates the relationship between gravitational force and upper-limb mobility by analyzing hand trajectories from 24 ...
Anna Bucchieri, Federico Tessari, Stefano Buccelli, Elena De Momi, Matteo Laffranchi, Lorenzo De Michieli   +5 more
doaj   +1 more source

Effect of in situ treatment on the quality of flat thermoplastic composite plates made by automated fiber placement (AFP)

Advanced Manufacturing: Polymer & Composites Science, 2018
Composite structures used as aerosurfaces in aerodynamic applications are required to have a certain surface finish quality. In manufacturing of thermoplastic composites using automated fiber placement (AFP) for aerodynamic applications, it is not only ...
F. Shadmehri, S. V. Hoa, J. Fortin-Simpson, H. Ghayoor   +3 more
doaj   +1 more source