Results 171 to 180 of about 48,623 (300)

RUNX1‐Driven CPXM1 Transcription Promotes Malignant Phenotypes and EMT in Gastric Cancer Cells

Cancer Science, EarlyView.
RUNX1 transcriptionally activates CPXM1, promotes EMT, and enhances the proliferation, invasion, and metastasis of gastric cancer cells. ABSTRACT Gastric cancer (GC) remains a leading cause of cancer‐related mortality worldwide, with current treatment strategies largely limited to surgery, chemotherapy, and targeted therapy.
Ping Jia, Fengming Xu, Tao Zhou, Pingping Wang, Huiping Chen, Jing Zhang, Xiaochen Yuan, Haoxun Xu, Yu Ouyang   +8 more
wiley   +1 more source

Effects of Helleborus thibetanus extract, a novel plant-derived molluscicide on Oncomelania hupensis, the intermediate host of Schistosoma japonicum. [PDF]

PLoS One
Yu H, Qu G, Wang L, Jin J, Xing Y.
europepmc   +1 more source

Pleiotropic Roles of FBXO11 in Tumorigenesis: Implications for Targeted Therapy

Cancer Science, EarlyView.
This complex comprises of scaffold CUL1, SKP1, RBX1 and FBXO11 receptor. The substrate is phosphorylated by specific kinase enzyme and recognized by the substrate recognition domain. FBXO11 targets numerous substrates for ubiquitination and degradation, FBXO11 substrates mainly include Snail, ZEB1, p53, BCL6, CDT2, CIITA, Cdc25a, hnRNPA2B1, SAMD1 and ...
Yuqi Zhang, Changyi Fan, Shiheng Chen, Tianyue Lu, Yuanyuan Li, Feng Du, Shanshan Wang   +6 more
wiley   +1 more source

Longitudinal malacological monitoring, with a parasitological survey, reveals new schistosomiasis transmission foci in deforested sites in Western Uganda. [PDF]

BMC Environ Sci
Oguttu DW, Nkolokosa C, Kiberu D, Odongo M, Besigye F, Juhasz A, Barungi W, Huyse T, Kabatereine NB, Tolo CU, Elliott AM, Webster BL, Stothard JR.   +12 more
europepmc   +1 more source

Genotype‐Informed Whole‐Animal Kinome Screening Reveals Shared Kinase Vulnerabilities Across Driver Contexts in PDAC

Cancer Science, EarlyView.
Overview of experimental workflow and key findings. Clinically prevalent 2‐hit and 3‐hit PDAC genotypes were first modeled in Drosophila to enable kinome‐wide genetic screening. Candidate therapeutic targets were prioritized using human tumor expression data and pathway enrichment analyses.
Han Hai, Takako Ooshio, Hui Jiang, Taku Kimura, Yusuke Satoh, Soichiro Hata, Taiga Hirata, Jiayi Liu, Tongwei Liu, Ryodai Yamamura, Masahiro Sonoshita   +10 more
wiley   +1 more source

Occurrence of brachylaimid trematodes, alive and shell-trapped, in sympatric species of terrestrial gastropods in France. [PDF]

Parasite
Gérard C, Dahirel M, Martin MC, Ansart A.   +3 more
europepmc   +1 more source

CDK4/6 Inhibitors and Curcumin Synergistically Suppress HER2− Breast Cancer via Lethal ROS and Inhibition of Metastasis

Cancer Science, EarlyView.
Schematic illustrating that CDK4/6 inhibitors combined with curcumin induce lethal ROS accumulation by disrupting redox balance, downregulating GPX4, and depleting glutathione, leading to DNA damage and lipid peroxidation. This oxidative stress triggers tumor cell death and suppresses EMT‐driven migration.
Chenyu Wang, Yiqin Zou, Chunyu Chang, Siyue Liu, Xiankun Ke, Liang Hu, Di Wang, Yukang Lu, Shiwen Luo, Sijian Huang, Yilan Hu, Wenqi Yu, Aiping Deng, Ming Yue, Jue Jiang   +14 more
wiley   +1 more source

Dystocia in Pet Giant African Land Snails. [PDF]

Animals (Basel)
Schmidt-Ukaj S, Gumpenberger M.
europepmc   +1 more source

NEDD4 Promotes Hepatocellular Carcinoma Progression Through Ubiquitin‐Dependent Degradation of EPHB6

Cancer Science, EarlyView.
NEDD4 drives K48‐linked polyubiquitination and proteasomal degradation of EPHB6, activating TGF‐beta SMAD2/3 signaling and upregulating EMT markers to promote tumor progression. ABSTRACT Neural precursor cell expressed developmentally down‐regulated 4 (NEDD4) has been implicated in the progression of various human malignancies, including hepatocellular
Guowei Zhang, Mengxuan Ji, Zhiyi Liu, Jiawei Xu, Qinghe Hu, Xue Zhang, Jie Qiu, Kai Wu, Bin Zhang, Yi He, Hengliang Shi   +10 more
wiley   +1 more source

Mytilus edulis-mediated green synthesis of selenium nanoparticles with antimicrobial and molluscicidal applications. [PDF]

Sci Rep
Dokmak HA, AlSedawy M, Ramadan MA, Amin BH, Faid AH, Abdelmaksoud HF, El-Sayed SM.   +6 more
europepmc   +1 more source