Results 191 to 200 of about 48,623 (300)

Methyl 4‐O‐Demethylbarbatate Destabilises HIF‐1α and Enhances Temozolomide Sensitivity in Glioma Cells

Cell Proliferation, EarlyView.
The lichen‐derived metabolite methyl 4‐O‐demethylbarbatate (Me‐4‐O‐DBA) suppresses glioma stemness, motility, and metabolic plasticity through inhibition of HIF‐1α signaling and synergistically enhances temozolomide activity, highlighting a potential strategy to target stemness‐driven therapeutic resistance in glioma.
Rui Zhou, Mücahit Varlı, Rundong Liu, Jieun Yu, Hyung‐Ho Ha, Jae‐Seoun Hur, Sang Kyum Kim, Hahyun Park, Hangun Kim   +8 more
wiley   +1 more source

Epigenetic and metabolic reprogramming of innate immune cells establishes immunological memory in the Schistosomiasis vector snail Biomphalaria glabrata. [PDF]

PLoS Pathog
Pichon R, Pinaud S, Chaparro C, Fallet M, Lebron R, Allienne JF, Turtoi E, Grunau C, Turtoi A, Duval D, Galinier R, Cosseau C, Gourbal B.   +12 more
europepmc   +1 more source

Targeting a Novel AREG+ Dendritic Cell Alleviates Renal Fibrosis Induced by Ischemia–Reperfusion Injury

Cell Proliferation, EarlyView.
Renal IRI induces tubular EMT and fibrosis. CD11c+AREG+ DCs mediate the process via AREG‐EGFR axis, serving as promising therapeutic targets. ABSTRACT Renal ischemia–reperfusion injury (RIRI) is a major cause of acute tubular damage and a key driver of maladaptive repair and fibrosis.
Xin Luo, Longbin Xiong, Zhaohui Zhou, Lihao Zhang, Yulu Peng, Xiangpeng Zou, Yixin Huang, Yisong Lin, Xiaofeng Yang, Zhanji Zhan, Fangjian Zhou, Youhua Liu, Chunping Yu, Baokui Ye, Zhiling Zhang   +14 more
wiley   +1 more source

A systems-level analysis of global gene expression in resistant and susceptible <i>Biomphalaria glabrata</i> in response to <i>Schistosoma mansoni</i> infection. [PDF]

Front Immunol
Lekired A, Adema CM, Zhang SM.
europepmc   +1 more source

Island invertebrate responses to single‐ and multi‐species invasive rodent eradications

Conservation Science and Practice, EarlyView.
Eradications of rodents on islands are a powerful tool for conservation, but rarely are the responses of invertebrates quantified post‐eradication, despite being the preferred prey of mice. Here we analyzed pre‐ and post‐eradication invertebrate survey results for two sub‐Antarctic islands where mice had recently been eradicated; Antipodes Island where
Mélissa J. Houghton, Aleks Terauds, James C. Russell, Michael Driessen, Mark I. Stevens, Hugh Possingham, Penelope Pascoe, Justine D. Shaw   +7 more
wiley   +1 more source

Estivation Strategies of Invasive Snail <i>Pomacea canaliculata</i> in Paddy Fields: Roles of Gut Microbiota and Digestive Gland Metabolism. [PDF]

Ecol Evol
Yao F, He Y, Chen Y, Zhang J, Shi Z, Qin Z.   +5 more
europepmc   +1 more source

Epigenetic control of cellular plasticity in breast cancer progression

The FEBS Journal, EarlyView.
Cancer cells undergo cell state transitions, termed plasticity, driving cancer progression and dictating therapeutic response. We define breast cancer plasticity into four interconnected processes: (1) breast cancer stem cell fates, (2) epithelial‐to‐mesenchymal transition, (3) maintenance of luminal identity, and (4) acquisition of therapeutic ...
Ellie J. Massey, Elizabeth Podleszanski, William J. Muller   +2 more
wiley   +1 more source

Toward transgenic multicellular parasites: CRISPR-Cas12a germline editing of <i>Schistosoma mansoni</i> eggs as key to success. [PDF]

Sci Adv
Moescheid MF, Wisitpongpun P, Gross V, Mann VH, Quack T, Rognon A, Grunau C, Ittiprasert W, Brindley PJ, Grevelding CG.   +9 more
europepmc   +1 more source

Snails and slugs

The class Gastropoda comprises snails, semi-slugs and slugs. A snail has an organic to calcareous coiled shell, into which its soft body can be fully retracted. On the other hand, a semi-slug shows a reduced shell that is embedded under the mantle tissue,
Nurul Syafiqah, Nasir, Mohd Zacaery, Khalik   +1 more
core  

Diachronic Trends in Dental Hygiene Over the Last 2000 Years in Milan, Italy: An Exploratory Study

International Journal of Dental Hygiene, EarlyView.
ABSTRACT Background Oral health is a multi‐factorial condition influenced by diet, hygiene and sociocultural habits and its historical evolution can be traced through the bioarchaeological analysis of dento‐skeletal remains, offering unique insights into past lifestyles and public health trends.
Lucie Biehler‐Gomez, Marta Ascoli, Giulia Masini, Maria Claudia Manicone, Dolaji Henin, Claudia Dellavia, Daniela Carmagnola, Alessandro Porro, Cristina Cattaneo, Danilo De Angelis   +9 more
wiley   +1 more source