Results 171 to 180 of about 3,204 (201)
Entwicklung und in vitro Evaluierung von SNEDDS-Formulierungen mit verschiedenen Fettsäuren
, 2017 openaire +1 more source
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International Journal of Pharmaceutics, 2023
A QbD-DM3 strategy was used to design ketoprofen (KTF) optimized liquid (L-SNEDDS) and solid self-nanoemulsifying drug delivery systems (S-SNEDDS). Principal component analysis was used to identify the optimized L-SNEDDS containing Capmul® MCM NF, 10 % w/w; Kolliphor® ELP, 60 % w/w; and propylene glycol, 30 % w/w. The S-SNEDDS was manufactured by spray-
Vivek D, Patel +3 more
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A QbD-DM3 strategy was used to design ketoprofen (KTF) optimized liquid (L-SNEDDS) and solid self-nanoemulsifying drug delivery systems (S-SNEDDS). Principal component analysis was used to identify the optimized L-SNEDDS containing Capmul® MCM NF, 10 % w/w; Kolliphor® ELP, 60 % w/w; and propylene glycol, 30 % w/w. The S-SNEDDS was manufactured by spray-
Vivek D, Patel +3 more
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A Review on Solid Supersaturable SNEDDS
Research Journal of Pharmacy and Technology, 2020More than 60% of the discovered drugs have the problem of low aqueous solubility which leads to their poor dissolution and reduced bioavailability. There are many techniques to overcome this problem like cyclodextrin complexation, salt formation, particle size reduction, solid dispersion, lipid based formulations, etc.
R. Santhosh Kumar, R. Sureshkumar
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FORMULATION AND OPTIMIZATION OF FUROSEMIDE SNEDDS: A COMPREHENSIVE STUDY
Critique Open Research & Review, 2023This research explores the development and optimization of Self-Nanoemulsifying Drug Delivery Systems (SNEDDS) for enhancing the oral bioavailability of Furosemide, a widely used diuretic with poor aqueous solubility. The study focuses on the systematic formulation of Furosemide-loaded SNEDDS to overcome the challenges associated with its limited ...
S. P. Nandita +2 more
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European Journal of Pharmaceutics and Biopharmaceutics, 2019
The effect of drug load and digestion on the solubilization and absorption of fenofibrate in self-nanoemulsifying drug delivery system (SNEDDS) was assessed in a pharmacokinetic study in rats and in an in vitro lipolysis model. SNEDDS containing fenofibrate at 75% of equilibrium solubility (Seq), a super-saturated SNEDDS (super-SNEDDS) containing ...
Michaelsen, Maria Høtoft +5 more
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The effect of drug load and digestion on the solubilization and absorption of fenofibrate in self-nanoemulsifying drug delivery system (SNEDDS) was assessed in a pharmacokinetic study in rats and in an in vitro lipolysis model. SNEDDS containing fenofibrate at 75% of equilibrium solubility (Seq), a super-saturated SNEDDS (super-SNEDDS) containing ...
Michaelsen, Maria Høtoft +5 more
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Expert Opinion on Drug Delivery, 2016
This study aims to illustrate the applicability of solid supersaturated self-nanoemulsifying drug delivery system (sat-SNEDDS) for the improvement of rosuvastatin calcium (RC) oral bioavailability.Different sat-SNEDDS were prepared by incorporating different ratios of RC into SNEDDS using tween80/PEG400 (77.2%) as surfactant/cosurfactant mixture and ...
Hadel A, Abo Enin +1 more
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This study aims to illustrate the applicability of solid supersaturated self-nanoemulsifying drug delivery system (sat-SNEDDS) for the improvement of rosuvastatin calcium (RC) oral bioavailability.Different sat-SNEDDS were prepared by incorporating different ratios of RC into SNEDDS using tween80/PEG400 (77.2%) as surfactant/cosurfactant mixture and ...
Hadel A, Abo Enin +1 more
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3D printing of patient-tailored SNEDDS-based suppositories of lidocaine
Journal of Drug Delivery Science and Technology, 2021Abstract Personalized drug delivery systems are considered an interesting perspective of the 3D printing technology, with the potential to counterbalance the pharmacological and adverse effects of pharmaceutical products. Our study was focused on the utilization of the pressure-assisted microsyringes technology to fabricate patient-tailored lidocaine-
Aikaterini-Theodora Chatzitaki +7 more
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Novel semisolid SNEDDS based on PEG-30-dipolyhydroxystearate: Development and characterization
International Journal of Pharmaceutics, 2014The aim of the current study is to explore the potential of PEG-30-dipolyhydroxystearate (Cithrol(®) DPHS) and Soluplus(®) as ingredients in novel semisolid self-nanoemulsifying drug delivery systems (SNEDDS). Semisolid SNEDDS consisting of Cithrol(®) DPHS, Capmul(®) MCM and Kolliphor(®) HS 15 were successfully prepared.
Tamer H, Hassan +2 more
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A Novel Pulsatile Release Film Coated Tablet of Zaltoprofen Loaded SNEDDS
Research Journal of Pharmacy and Technology, 2021The aim of the present study was to formulate pulsatile release film coated tablet of zaltoprofen for the treatment of rheumatoid arthritis. Initially solubility of zaltoprofen was enhanced by formulating self emulsifying fast disintegrating tablet of zaltoprofen.
Rajan Kalamkar +2 more
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SNEDDS- A New Frontier in Oral Drug Delivery
International Journal of Pharmaceutical Sciences and Nanotechnology(IJPSN)Self-Nano-Emulsifying Drug-Delivery Systems (SNEDDS) are a novel method to increase the oral bioavailability of poorly soluble drugs and are one of the latest in the business today. Such systems are composed of oil, surfactant, and co-surfactant, which can, in the wake of their dilution in aqueous media, instantaneously produce the nano emulsions.
Medha Gayatri B, Vasanthi A. V
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