Results 111 to 120 of about 400,356 (307)

Cross‐Modal Denoising and Integration of Spatial Multi‐Omics Data with CANDIES

Advanced Science, EarlyView.
In this paper, we introduce CANDIES, which leverages a conditional diffusion model and contrastive learning to effectively denoise and integrate spatial multi‐omics data. We conduct extensive evaluations on diverse synthetic and real datasets, CANDIES shows superior performance on various downstream tasks, including denoising, spatial domain ...
Ye Liu, Wanpeng Zou, Yuekai Li, Jiayi Wang, Mingxuan Cai, Hongmin Cai   +5 more
wiley   +1 more source

rSNPBase 3.0: an updated database of SNP-related regulatory elements, element-gene pairs and SNP-based gene regulatory networks

, 2017
Here, we present the updated rSNPBase 3.0 database (http://rsnp3.psych.ac.cn), which provides human SNP-related regulatory elements, element-gene pairs and SNP-based regulatory networks.
Jing Wang, Liyuan Guo, Guo, Liyuan, Wang, Jing   +3 more
core   +1 more source

Multi‐Omics Insights Into the Mechanisms of Early Muscle Fiber Difference and Transformation Between Lean‐Type and Chinese Indigenous Pigs

Advanced Science, EarlyView.
Multi‐omics analyses uncover breed‐specific cis‐regulatory landscapes and higher‐order chromatin architectural differences that underlie early postnatal muscle fiber divergence in pigs. A super‐enhancer upstream of PPP3CB recruits MEF2C to activate PPP3CB transcription, while the PPP3CB–MEF2C positive feedback loop promotes oxidative muscle fiber ...
Shuailong Zheng, Hainan Wu, Min Liu, Kunpeng Wu, Shuntao Huang, Zulfiqar Ahmed, Lenox Pius, Mengjin Zhu, Dequan Xu   +8 more
wiley   +1 more source

A Multi-Biomarker Approach to Increase the Accuracy of Diagnosis and Management of Coronary Artery Disease

Journal of Cardiovascular Development and Disease
Non-invasive possibilities of predicting cardiovascular risk and monitoring the treatment and progression of coronary artery disease (CAD) are important subjects of cardiovascular research.
Lenka Hostačná, Jana Mašlanková, Dominik Pella, Beáta Hubková, Mária Mareková, Daniel Pella   +5 more
doaj   +1 more source

SNP-ID and primer sequences of selected breed-specific SNPs of Polish HF cattle.

, 2016
SNP-ID and primer sequences of selected breed-specific SNPs of Polish HF cattle.
Paweł Błaszczyk (3110316), Leyland Fraser (3110304), Haja N. Kadarmideen (419115), Przemysław Sobiech (3110313), Lech Zwierzchowski (3110298), Yaping Feng (427666), Krzysztof Wąsowicz (3110310), Dibyendu Kumar (3110295), Magdalena Ogluszka (3110286), Mariusz Pierzchała (3110292), Paulina Walendzik (3110274), Chandra Shekhar Pareek (3110277), Urszula Czarnik (3110289), Brian Gelfand (3110301), Jarosław Horbańczuk (3110307), Piotr Dziuba (3110283), Agnieszka Szostak (3110271), Marcin Sikora (2706196), Rafał Smoczyński (3110280), Tomasz Grzybowski (103542)   +19 more
core   +1 more source

Introgressed Variation in TaMYB7‐A1 Drives Graded Dormancy and Climate‐Adaptive Pre‐Harvest Sprouting Resistance in Wheat

Advanced Science, EarlyView.
TaMYB7‐A1 directly activates TaABI5 to enhance ABA signaling and regulate ABA‐GA homeostasis, enforcing seed dormancy. Its superior allele, derived from wild einkorn introgression, harbors a MITE insertion that elevates expression and two amino acid substitutions that enhance transcriptional activity, collectively generating graded PHS resistance for ...
Hao Wang, Dongzhi Wang, Yafei Guo, Qi Zheng, Min Zhang, James Simmonds, Jian Hou, Xuemei Liu, Xuelei Lin, Xiaomin Bie, Xiansheng Zhang, Xiaohui Li, Yuan Chen, Xueyong Zhang, Cristobal Uauy, Fei Lu, Chengcai Chu, Zhixi Tian, Jun Xiao   +18 more
wiley   +1 more source

SNP-SNP Interaction Analysis on Soybean Oil Content under Multi-Environments.

, 2016
Soybean oil content is one of main quality traits. In this study, we used the multifactor dimensionality reduction (MDR) method and a soybean high-density genetic map including 5,308 markers to identify stable single nucleotide polymorphism (SNP)-SNP ...
Zhanguo Zhang (3138240), Guohua Hu (582862), Zhongqiu Ni, Zhaoming Qi (613782), Dawei Xin, Chunyan Liu, Rongsheng Zhu (613783), Xinrui Mao, Zhongqiu Ni (821942), Hongwei Jiang, Chunyan Liu (44864), Qingshan Chen, Rongsheng Zhu, Huiying Jia (2457178), Xue Han (25073), Xue Han, Zhaoming Qi, Zhenbang Hu, Zhengong Yin (3138228), Zhenbang Hu (2550814), Dawei Xin (613784), Xiaoxia Wu, Zhanguo Zhang, Huiying Jia, Yue Leng, Zhengong Yin, Hongxiao Yu, Qingshan Chen (528259), Yue Leng (3138237), Xinrui Mao (3138231), Shanshan Jiang (382941), Hongwei Jiang (402234), Guohua Hu, Hongxiao Yu (3138234), Shanshan Jiang, Xiaoxia Wu (671551)   +35 more
core   +1 more source

The Landscape and Regulation of Histone Crotonylation in Mammalian Gametes and Early Embryos

Advanced Science, EarlyView.
Histone crotonylation undergoes a genome‐wide transition from broad domains to canonical narrow peaks during minor zygotic genome activation (ZGA). This remodeling is required for proper major ZGA and blastocyst formation. Disruption of this transition by transcriptional inhibition, metabolic perturbation, or HDAC1 dysfunction impairs embryonic ...
Shenli Yuan, Yelian Yan, Yalin Liang, Kanghua Zhong, Zhican Fu, Xiaobo Wang, Chao Liu, Tao Huang, Keliang Wu   +8 more
wiley   +1 more source

Eco‐Geography Reverses Dominant AMR Reservoirs in Klebsiella pneumoniae: Integron‐Rich Mobilomes and Cross‐Niche Connectivity

Advanced Science, EarlyView.
Dominant antimicrobial resistance reservoirs in Klebsiella pneumoniae vary across eco‐geographic settings rather than following a universal pattern. Integrated One Health and global genomic analyses show that lineage structure, integron load, and cross‐niche connectivity shape whether AMR burden accumulates primarily in human or nonhuman compartments ...
Hui Lin, Biao Tang, Hao Xu, Jiajie Qian, Feifan Shi, Junhui Zhao, Xiaorui Mao, Xiaohe Hu, Ruishan Liu, Wenhong Liu, Xiawei Jiang, Beiwen Zheng, Guoping Zhao   +12 more
wiley   +1 more source

Information about the 43-SNP-based molecular barcode and diversity among panel 1 accessions.

, 2016
Information about the 43-SNP-based molecular barcode and diversity among panel 1 accessions.
LiFeng Gao (3177816), XiuYing Kong (3177813), JiZeng Jia (3177819)   +2 more
core   +1 more source