Results 91 to 100 of about 605,833 (293)
Advanced Science, EarlyView.This study presents the first telomere‐to‐telomere genomes and population resources for Diaporthe pathogens, uncovering the largest known fungal repertoire of secondary metabolite gene clusters. Structural variations and horizontal gene transfer drive cluster diversification, while specific rapidly evolving clusters control virulence, offering novel ...
Kainan Li +9 more
wiley +1 more source
Caffeinated Beverages—Unveiling Their Impact on Human Health
BeveragesCaffeine is among the most commonly used and consumed stimulants worldwide. It is a naturally occurring stimulant mainly found in coffee and tea. It is also present in sweetened beverages, which are very popular among young people.
Beáta Čižmárová +2 more
doaj +1 more source
Gene and Pathway-Based Analysis: Second Wave of Genome-wide Association Studies [PDF]
, 2008 Despite great success of GWAS in identification of common genetic variants associated with complex diseases, the current GWAS have focused on single SNP analysis.
Christopher I. Amos +11 more
core +1 more source
Simultaneous SNP identification in association studies with missing data
, 2012 Association testing aims to discover the underlying relationship between genotypes (usually Single Nucleotide Polymorphisms, or SNPs) and phenotypes (attributes, or traits).
Casella, George +4 more
core +1 more source
Advanced Science, EarlyView.A flexible, ultrathin multi‐channel microelectrode array (MEA) conformally integrated onto a curved slide‐well enables stable electrical interfacing with 3D cardiac organoids. The geometry‐guided self‐alignment allows simultaneous recording of extracellular field potentials and contractile motion from irregular, beating tissues.
Ye Seul Kim +12 more
wiley +1 more source
Listy klinicke logopedie, 2020 Carcinoma of the oropharynx represents the most common malignant disease of the pharynx. In our paper, we deal with the case study of a patient with acquired rhinophonia aperta and dysphagia as concomitant symptoms of the surgical treatment, radiation ...
Silvia Adzimová
doaj +1 more source
Relationships Among Beef Cow Productivity Traits and Single Nucleotide Polymorphisms in the Bovine Heat Shock Protein 70 Gene [PDF]
, 2018 When eukaryotes are exposed to stressors such as heat, toxins, and low oxygen levels, heat shock proteins (HSPs) are synthesized to maintain normal cellular function within the body.
Finney, Ashley
core +2 more sources
On The Delays In Spiking Neural P Systems
, 2012 In this work we extend and improve the results done in a previous work on simulating Spiking Neural P systems (SNP systems in short) with delays using SNP systems without delays.
Adorna, Henry N. +2 more
core +1 more source
Embedded CRISPRi Enhances Gene‐Silencing Efficiency in Drosophila
Advanced Science, EarlyView.Current CRISPR interference (CRISPRi) technology in Drosophila has limited efficiency. This study introduces the emCRISPRi platform, which significantly enhances transcriptional silencing efficacy by embedding inhibitory domains within the dCas9 architecture.
Pengchong Fu +7 more
wiley +1 more source
Advanced Science, EarlyView.This study reveals that abnormal mechanical stress downregulates the expression of HSP70 and impairs proteasome function in osteoarthritic bone cells, leading to misfolded collagen I accumulation and ER stress. When intracellular proteostasis capacity is exceeded, USP19 mediates the secretion of misfolded proteins into the extracellular space ...
Hailun Xu +20 more
wiley +1 more source