Results 81 to 90 of about 605,833 (293)
Fluorescence biomarkers of malignant melanoma detectable in urine
Open Chemistry, 2020 Malignant melanoma (MM) is a cancerous transformation of melanocytes. It is a disease with the worst response to therapy and, compared to other malignancies, presents much earlier with metastases.
Špaková Ivana +3 more
doaj +1 more source
Accurate estimation of SNP-heritability from biobank-scale data irrespective of genetic architecture. [PDF]
, 2019 SNP-heritability is a fundamental quantity in the study of complex traits. Recent studies have shown that existing methods to estimate genome-wide SNP-heritability can yield biases when their assumptions are violated.
Burch, Kathryn S +7 more
core
Advanced Functional Materials, EarlyView.Synthesis and characterization of light‐responsive donor–acceptor Stenhouse adducts (DASA)‐coated chlorhexidine‐loaded silica nanoparticles. Such a controllable drug‐delivery system enables the release of the antimicrobial drug on demand and in consecutive cycles, thereby maintaining the concentration within the therapeutic window.
Michèle Clerc +9 more
wiley +1 more source
Proteomic and bioinformatics analysis of human saliva for the dental-risk assessment
Open Life Sciences, 2017 Background: Dental caries disease is a dynamic process with a multi-factorial etiology. It is manifested by demineralization of enamel followed by damage spreading into the tooth inner structure.
Laputková Galina +5 more
doaj +1 more source
High‐Throughput SNP Genotyping [PDF]
ChemInform, 2002 AbstractWhole genome approaches using single nucleotide polymorphism (SNP) markers have the potential to transform complex disease genetics and expedite pharmacogenetics research. This has led to a requirement for high‐throughput SNP genotyping platforms. Development of a successful high‐throughput genotyping platform depends on coupling reliable assay
Jenkins, Suzanne, Gibson, Neil
openaire +2 more sources
GenEpi: gene-based epistasis discovery using machine learning. [PDF]
, 2020 BackgroundGenome-wide association studies (GWAS) provide a powerful means to identify associations between genetic variants and phenotypes. However, GWAS techniques for detecting epistasis, the interactions between genetic variants associated with ...
Alzheimer’s Disease Neuroimaging Initiative +9 more
core
A novel human glucocorticoid receptor SNP results in increased transactivation potential. [PDF]
, 2017 Glucocorticoids are one of the most widely used therapeutics in the treatment of a variety of inflammatory disorders. However, it is known that there are variable patient responses to glucocorticoid treatment; there are responders and non-responders, or ...
Cho, Kiho +5 more
core +3 more sources
Advanced Healthcare Materials, EarlyView.This study developed a bioprinted co‐culture system embedding rat pancreatic islets and Scenedesmus sp. microalgae spatially defined in close vicinity. Red light was found optimal to ensure microalgal photosynthesis while maintaining islet viability and functionality. A tailored co‐culture medium supported both cell types.
Finn Dani +7 more
wiley +1 more source
Listeria in Pregnancy—The Forgotten Culprit
MicroorganismsListeria monocytogenes is a Gram-positive bacterium that causes listeriosis, a severe foodborne illness that is particularly dangerous during pregnancy. It thrives in diverse environments, including refrigerated conditions and food production facilities,
Vladimír Kraus +2 more
doaj +1 more source
Advanced Science, EarlyView.Aldosterone‐producing adenomas (APAs) develop via two distinct paths: directly from adrenal zona glomerulosa (zG) cells, or stepwise from zG cells through aldosterone‐producing micronodules (APMs) before progressing to APAs. Advanced single‐cell and spatial analyses identified distinct cell states linked to oxidative stress and cell–cell interactions ...
Zhuolun Sun +7 more
wiley +1 more source