Results 81 to 90 of about 375,450 (258)

Cross-Amplification and Validation of SNPs Conserved over 44 Million Years between Seals and Dogs [PDF]

, 2013
Hoffman J, Thorne MAS, McEwing R, Forcada J, Ogden R. Cross-Amplification and Validation of SNPs Conserved over 44 Million Years between Seals and Dogs. PLoS ONE.
Rob Ogden (145264), Hoffman, Joseph ; https://orcid.org/, Thorne, Michael A. S., Hoffman, Joseph I., Thorne Michael A. S., Joseph I. Hoffman (210226), Ogden Rob, Jaume Forcada, Forcada, Jaume, Michael A S Thorne, Michael A. S. Thorne, Hoffman Joseph I., Forcada Jaume, Rob Ogden, Joseph I. Hoffman, Michael A. S. Thorne (107836), Ogden, Rob, Rob McEwing (433786), Jaume Forcada (344093), McEwing Rob, McEwing, Rob, Rob McEwing, Joseph I Hoffman   +22 more
core   +2 more sources

FUCA2 Sustains AKT Signaling and Suppresses Senescence by Antagonizing FUT3‐Mediated ErbB3 Fucosylation in Lung Adenocarcinoma

Advanced Science, EarlyView.
ABSTRACT While targeted therapies have improved outcomes in lung adenocarcinoma (LUAD), many patients still lack targetable mutations. Here, we identified alpha‐L‐fucosidase 2 (FUCA2) as a crucial driver of LUAD by preventing cellular senescence. Mechanistically, through the restriction of fucosyltransferase 3 (FUT3)‐mediated α‐1,3‐fucosylation of ...
Lu Chen, Jintao Guo, Fei Li, Mingjie Gao, Runyang Li, Zhaozhang Huang, Yaolin Zheng, Chunyi Gao, Jihuan Hou, Qiang Yu, Bowen Zheng, Xuemei Chen, Wenqing Zhang, Xiaoting Hong, Yali Zheng, Daxuan Wang, Qiyuan Li, Tianhui Hu, Yan‐yan Zhan   +18 more
wiley   +1 more source

Identificação e caracterização de repetições de seqüências simples (microssatélites) e de polimorfismos de nucleotídeos únicos (SNP) em Trypanosoma rangeli e suas implicaçoes no estudo da estrutura populacional do parasito [PDF]

, 2012
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Biotecnologia, Florianópolis, 2009.O presente estudo realizou a identificação e análise de polimorfismos de nucleotídeos únicos (SNP)
Sincero, Thaís Cristine Marques
core  

Transposase‐Assisted Donor Tethering Boosts Large‐Fragment HDR in Plants

Advanced Science, EarlyView.
A transposase‐assisted donor tethering strategy is developed to enhance homology‐directed repair in plants. By recruiting donor DNA to double‐strand breaks and synergizing with repair pathway reprogramming and transcription‐coupled donor design, this system markedly improves large‐fragment targeted insertion efficiency, providing a robust platform for ...
Sha Wei, Kai Zhang, Shuke Deng, Jinjie Chen, Xiaomei Huang, Jingfei Guo, Yuqing Wu, Yingjie Guo, Zhen Liang   +8 more
wiley   +1 more source

The RNA‐Binding Protein PARN Remodeled 3′ UTR Structure Defines Poly(A)‐Loading Sites to Mediate Immunoglobulin Homeostasis

Advanced Science, EarlyView.
ABSTRACT Class Switch Recombination (CSR) is essential for generating high‐affinity antibody isotypes from IgM during adaptive humoral responses. Despite well‐established roles for various transcription factors, whether CSR is subject to dedicated post‐transcriptional control represents a significant gap in knowledge.
Siyuan Sun, Chen Yang, Xiaoyu Wang, Naijing Hu, Shengyao Zhang, Xinchun Li, Yu Chen, Jianan Zhai, Xiangfeng Tang, Wei Lu, Chenxu Lu, Changchang Cao, Weiru Yu, Wenhao Wu, Xiaonan Nie, Fengchao Wang, Bing Fang, Fazheng Ren, Yixuan Li, Juan Chen   +19 more
wiley   +1 more source

SNP- and weight selection flowchart with number of SNPs for each obesity trait. [PDF]

, 2019
SNPs were selected by combining the primary (“index”) variants associated with the obesity traits P−9 in a meta-analysis of GIANT and UK Biobank [14,22].
Teresa Ferreira (418982), Jonas Bovijn (7541741), Reedik Mägi (667294), Jenny C. Censin (7541735), Anubha Mahajan (206768), Michael V. Holmes (7541747), Cecilia M. Lindgren (7541750), Sara L. Pulit (7541744), Sanne A. E. Peters (7541738)   +8 more
core   +1 more source

NLSS3 Impairs SHM1 Autophagic Degradation to Regulate Leaf Morphology and Salt Tolerance in Rice

Advanced Science, EarlyView.
In rice, NLSS3 binds and shields SHM1 from autophagic degradation to maintain serine homeostasis. The A132P mutation in nlss3 disrupts this, triggering SHM1 loss, metabolic dysfunction, K+ imbalance, and impaired ROS scavenging, which collectively drive narrow leaves and salt sensitivity.
Xiong Liu, Yulu Yang, Zhiqi Hao, Jing Xu, Huibo Zhao, Qiang Zhang, Deyong Ren, Xia Li, Guojun Dong, Lan Shen, Li Zhu, Jiang Hu, Zhenyu Gao, Qing Li, Qian Qian, Guangheng Zhang   +15 more
wiley   +1 more source

SNP-based genotypes and genetic variation seen in 15 single clones in Western Kenya in 2013–2014. [PDF]

, 2016
Median-joining network diagram above shows genetic relationship of the western Kenya samples using 78 SNP haplotypes. Each circle in the network represents a unique haplotype profile with the size of the circle being proportional to the number of clones ...
Edwin Kamau (282162), Benjamin Opot (3111183), Lorna J. Chebon (844733), Jelagat Cheruiyot (844734), Mabel Imbuga (3111180), Hoseah M. Akala (584080), Bidii S. Ngalah (3111168), Ben Andagalu (584087), Luicer A. Ingasia (844731), Wallace Bulimo (584090), Dennis W. Juma (3111171), Emmanuel Mbuba (3111174), Peninah Muiruri (3111177)   +12 more
core   +1 more source

PlantGFM: A Genomic Foundation Model for Discovery and Creation of Plant Genes

Advanced Science, EarlyView.
A plant genomic foundation model pre‐trained on 12 species enables both accurate gene prediction and de novo gene design. Through AI‐human knowledge screening, seven designed sequences showed transcriptional activity in plants, with two expressing stable proteins—demonstrating the first DNA‐RNA‐protein expression of LLM‐generated genes in plants and ...
Changhao Li, Qizhe Zhang, Hanchen Chen, Kepeng Lin, Chengfang Luo, Mengying Yang, Wei Xu, Fan Yao, Jianbing Yan, Qing‐Yong Yang, Xuehai Hu   +10 more
wiley   +1 more source

Xenogeneic Mitochondrial Transplantation Improves Selected Age‐Associated Phenotypes in Mice

Advanced Science, EarlyView.
Yak‐derived xenogeneic mitochondrial transplantation improves selected age‐associated phenotypes in mice, enhances mitochondrial functional readouts, and engages host mitochondrial quality‐control pathways. Broad tissue biodistribution, increased ATP production and mtDNA copy number, reduced ROS levels and dysfunctional mitochondria, improved motility ...
Wenpeng Li, Xijia Wang, Yaning Hu, Zhen Yang, Tian Niu, Xingbo Zhao   +5 more
wiley   +1 more source