Results 61 to 70 of about 444,550 (269)

SNP-based genomic scans.

, 2023
These scans are similar to the heterozygosity-based analysis (Figs 4 and S9), but focusing on biallelic SNP changes (rather than accession-based frequencies).
Urszula Kania (16877777), Maaike de Jong (3161322), Sally Ward (766318), Ottoline Leyser (25869), Liron Shenhav (6845174), Hugo Tavares (7411373), Raj K. Pasam (7411376), Anne Readshaw (9231296), Hayley McCulloch (16877780), Elizabeth Forsyth (16877783)   +9 more
core   +1 more source

Augmenting and Assaying Nav1.1 Protein Quantity for Dravet Syndrome Therapy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Dravet Syndrome (DS) is a developmental and epileptic encephalopathy predominantly caused by heterozygous loss‐of‐function variants in SCN1A, which encodes Nav1.1. Conserved upstream open reading frames (uORFs) in SCN1A were validated to regulate translation in reporter assays, demonstrating the therapeutic viability of increasing Nav1.1 from ...
Aiswarya Saravanan, Jordan Safran, Anna Loughman, Grace Lin, Shivanshi Vaid, Dana Allababidi, Peter M. Tessier, Louis T. Dang   +7 more
wiley   +1 more source

The Anti-SLAMF7 Antibody, Elotuzumab, Induces Antibody-Dependent Cellular Cytotoxicity Against CLL Cell Lines

Molecules
SLAMF7, also known as CD319, a SLAM (signaling lymphocytic activation molecule) family receptor, is relatively weakly expressed on chronic lymphocytic leukemia (CLL) B cells.
Dominik Kľoc, Bianca Dubiková, Simona Žiláková, Ján Sykora, Michaela Šuliková, Slavomír Kurhajec, Ján Sabo, Tomáš Guman, Marek Šarišský   +8 more
doaj   +1 more source

Metabolites of Tryptophane and Phenylalanine as Markers of Small Bowel Ischemia-Reperfusion Injury

Open Chemistry, 2018
Ischemic-reperfusion injury of the small intestine is an acute clinical condition with high mortality rate. This study describes the changes in levels of phenylalanine and tryptophan metabolites in intestinal homogenates and urine samples of Wistar male ...
Mašlanková Jana, Tóth Štefan, Tomečková Vladimíra, Tóth Tímea, Katz Matan, Veselá Jarmila, Hertelyová Zdenka, Schnitzer Marek, Živčák Jozef, Mareková Mária   +9 more
doaj   +1 more source

SNP-index information of the three markers.

, 2016
SNP-index information of the three markers.
Yuanjun Ye (2872955), Ming Cai (342151), Huitang Pan (395889), Lu Feng (193271), Yiqian Ju (2872961), Qixiang Zhang (395887), Yao Jiao (2872958), Tangren Cheng (395888)   +7 more
core   +1 more source

Integrating Genetics With Epidemiological Measurements Identifies Burden QTLs of Inflammatory Bowel Disease across 20 Countries

Advanced Science, EarlyView.
The burden quantitative trait locus (bQTL) analysis integrates epidemiological data from GBD study with genotype of 2 621 978 SNPs from 2414 individuals in 1000 Genomes Project across 20 countries. rs7633471 shows the strongest effect that each increase in centi‐allele frequency of the allele C associated with 10.00 decrease of age‐standardized ...
Chen Sun, Siyu Wei, Junxian Tao, Haiyan Chen, Chi Yan, Jiacheng Wang, Jing Xu, Lian Duan, Yuanbo Zhan, Yuping Zou, Ruilin Li, Linna Yuan, Wei She, Songlin Lu, Ning Wang, Qinduo Ren, Yan Guo, Yuan Xu, Chang Wang, Hongsheng Tian, Chen Zhang, Yu Dong, Guoping Tang, Zhenwei Shang, Yongshuai Jiang, Wenhua Lv, Mingming Zhang, Hongchao Lyu   +27 more
wiley   +1 more source

Attomolar Detection of HIV‐1 With Label‐Free RCA‐rCRISPR on Smartphone

Advanced Science, EarlyView.
A new diagnostic strategy integrating rolling circle amplification (RCA) with a plasmid reporter–based ratiometric CRISPR (rCRISPR) system was developed to detect unfragmented HIV genomes with single‐digit attomolar sensitivity. The method quantifies targets using the plasmid relaxation ratio and employs a smartphone‐based mini‐gel device to enable ...
Noor Mohammad, Anastasiia Steksova, Yuyang Tang, Leyao Huang, Alireza Velayati, Shengwei Zhang, Aditi Dey Poonam, Sina Jamalzadegan, Matthew Breen, Hongjie Chen, Mahsa Bagi, Guochun Jiang, Qingshan Wei   +12 more
wiley   +1 more source

SNP-specific genotype frequencies for cases (YWC) and controls (CGEMS).

, 2019
SNP-specific genotype frequencies for cases (YWC) and controls (CGEMS).
Bryce G. Larson (6733730), Penelope Miron (171974), Laura C. Collins (416928), Kathryn J. Ruddy (5391302), Elena Brachtel (5044052), Meghan E. Meyer (6733727), Virginia Borges (5809064), Qiyuan Li (236147), Ji-Heui Seo (6733733), Hilde Vardeh (2922144), Michelle Rath (6733721), Mark Pomerantz (260848), Matthew Freedman (23592), Rulla M. Tamimi (437781), Anne E. Dowton (6733724), Lidia Schapira (549257), Sara Lindström (120789), Alexander Miron (28179), Ann H. Partridge (5249723), Huili Li (357603), Steven E. Come (416933)   +20 more
core   +1 more source

Lactiplantibacillus Plantarum GUANKE Alleviates Allergic Asthma by Restricting Monocyte‐to‐DC Differentiation Via Microbiota‐Associated IAA

Advanced Science, EarlyView.
Lactiplantibacillus plantarum GUANKE remodels the indigenous gut microbiota and is associated with microbiota‐dependent restoration of circulating IAA. IAA treatment attenuates JAK3‐STAT3 and Jag1‐Notch4‐Hey1 signaling and reduces CX3CR1+Ly6C− monocytic precursor generation and pulmonary CD11b+ DC accumulation, together with reduced Th2 inflammation ...
Yujia He, Jielan Mi, Zhiping Zhao, Xiao Zhang, Zhihan Yang, Kun Yue, Yuanming Huang, Liqiong Song, Xiaoting Wen, Jianguo Xu, Zhihong Ren   +10 more
wiley   +1 more source

Oxidative Stress and the Nrf2/PPARγ Axis in the Endometrium: Insights into Female Fertility

Cells
Successful pregnancy depends on precise molecular regulation of uterine physiology, especially during the menstrual cycle. Deregulated oxidative stress (OS), often influenced by inflammatory changes but also by environmental factors, represents a ...
Peter Artimovič, Zuzana Badovská, Silvia Toporcerová, Ivana Špaková, Lukáš Smolko, Gabriela Sabolová, Eva Kriváková, Miroslava Rabajdová   +7 more
doaj   +1 more source