Results 41 to 50 of about 605,833 (293)

Virulence, phylogenetic background and antimicrobial resistance in Escherichia coli associated with extraintestinal infections

Journal of Infection and Public Health, 2020
Background: Escherichia coli (E. coli) is a major cause of urinary tract infections and bloodstream infections and an important agent in the resistance to antibiotics.
Katarína Čurová, Radka Slebodníková, Marta Kmeťová, Vladimír Hrabovský, Matúš Maruniak, Erika Liptáková, Leonard Siegfried   +6 more
doaj   +1 more source

High Prevalence of Clostridioides difficile Ribotype 176 in the University Hospital in Kosice

Pathogens, 2023
Dysbiosis of the gut microbiota, caused by antibiotics, plays a key role in the establishment of Clostridioides difficile CD). Toxin-producing strains are involved in the pathogenesis of Clostridioides difficile infection (CDI), one of the most common ...
Katarina Curova, Martin Novotny, Lubos Ambro, Anna Kamlarova, Viera Lovayova, Vladimir Hrabovsky, Leonard Siegfried, Pavol Jarcuska, Peter Jarcuska, Annamaria Toporova   +9 more
doaj   +1 more source

Multiple breast cancer risk variants are associated with differential transcript isoform expression in tumors. [PDF]

, 2015
Genome-wide association studies have identified over 70 single-nucleotide polymorphisms (SNPs) associated with breast cancer. A subset of these SNPs are associated with quantitative expression of nearby genes, but the functional effects of the majority ...
Brenner, Steven E, Camarda, Roman, Caswell, Jennifer L, Goga, Andrei, Hu, Donglei, Huntsman, Scott, Zaitlen, Noah, Zhou, Alicia Y, Ziv, Elad   +8 more
core   +2 more sources

Proteomic Insight into Susac Syndrome Utilizing Tear Fluid—Case Study

Applied Sciences
Susac Syndrome (SuS) is a rare autoimmune neurovascular disorder characterized by sudden visual loss, hearing disturbances, and encephalopathy. Pathology affects the small vessels of the brain, retina, and inner ear.
Soňa Tkáčiková, Ivan Talian, Miroslav Marcin, Peter Bober, Tereza Ilavská, Simona Knížová, Miriama Turoková, Adriána Rašiová, Veronika Gibová, Vladimíra Tomečková   +9 more
doaj   +1 more source

Mesenchymal Stem Cells in the Treatment of Human Spinal Cord Injury: The Effect on Individual Values of pNF-H, GFAP, S100 Proteins and Selected Growth Factors, Cytokines and Chemokines

Current Issues in Molecular Biology, 2022
At present, there is no effective way to treat the consequences of spinal cord injury (SCI). SCI leads to the death of neural and glial cells and widespread neuroinflammation with persisting for several weeks after the injury.
Lucia Slovinska, Denisa Harvanova, Jana Janockova, Jana Matejova, Peter Cibur, Marko Moravek, Timea Spakova, Jan Rosocha   +7 more
doaj   +1 more source

Detection of Single Nucleotide Polymorphism Rs2013162 of IRF6 Gene in Patient with Cleft Lip and Palate [PDF]

, 2019
Background: Cleft lip and palate are congenital disorders which induce affected individuals medically, socially and psychologically. The objective of this study was to investigate the association of Single Nucleotide Polymorphism(SNP); rs2013162 of ...
Shehzad, H. (Husnain), Shehzad, O. (Osheen)   +1 more
core   +2 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The Epidemiology of Primary Biliary Cholangitis in European Countries: A Systematic Review and Meta-Analysis

Canadian Journal of Gastroenterology and Hepatology, 2021
Background. Primary biliary cholangitis (PBC) is a chronic autoimmune cholestatic liver disease with wide ranges of reported incidence and prevalence. Aim. To map the incidence and prevalence of PBC in European countries from 2000 through 2020.
Jakub Gazda, Sylvia Drazilova, Martin Janicko, Peter Jarcuska   +3 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Application of Telemedicine and Artificial Intelligence in Outpatient Cardiology Care: TeleAI-CVD Study (Design)

Diagnostics
Background/Objectives: Cardiovascular (CV) diseases remain the leading cause of morbidity and mortality across Europe. Despite substantial progress in prevention, diagnostics, and therapeutics, outpatient cardiology care continues to face systemic ...
Stefan Toth, Marianna Barbierik Vachalcova, Kamil Barbierik, Adriana Jarolimkova, Pavol Fulop, Mariana Dvoroznakova, Dominik Pella, Tibor Poruban   +7 more
doaj   +1 more source