Results 51 to 60 of about 375,450 (258)

Source code for snp-dists software [PDF]

, 2018
This tar.gz file contains the source code, test data, and documentation for snp-dists, a bioinformatics command line tool for calculating SNP distance matrix from a FASTA multiple sequence alignment.
Seemann, Torsten, Seemann, Torsten (5288968)   +1 more
core   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Identification of a sex-linked SNP marker in the salmon louse (Lepeophtheirus salmonis) using RAD sequencing [PDF]

, 2013
The salmon louse (Lepeophtheirus salmonis (Krøyer, 1837)) is a parasitic copepod that can, if untreated, cause considerable damage to Atlantic salmon (Salmo salar Linnaeus, 1758) and incurs significant costs to the Atlantic salmon mariculture ...
Carmichael, Stephen N, Bassett, David I, Stephen N. Carmichael, Bron, James, Christie, Hayden R. L., Skern-Mauritzen, Rasmus, Bekaert, Michaël, David I Bassett, James E Bron, John B. Taggart (208020), Rasmus Skern-Mauritzen, Bassett, David I., Gharb, Karim, Skuce, Philip J, Taggart John B., Bron, James E., Bron, James E, Hayden R. L. Christie (471364), David I. Bassett (471365), Bekaert Michaël, Sturm, Armin, Carmichael Stephen N., Stephen N Carmichael, Taggart, John B, Bassett, D I, Sturm Armin, John B. Taggart, James E. Bron (308427), Gharbi Karim, Hayden R. L. Christie, Christie, Hayden R L, John B Taggart, Skuce, Philip J., Skern-Mauritzen Rasmus, Hayden R L Christie, Skuce Philip J., Michaël Bekaert, Armin Sturm, Philip J Skuce, Karim Gharbi (432878), Karim Gharbi, Philip J. Skuce, Philip J. Skuce (471366), Bassett David I., Skuce, Phillip, David I. Bassett, Stephen N. Carmichael (471363), Taggart, John, James E. Bron, Christie Hayden R. L., Taggart, John B., Rasmus Skern-Mauritzen (457732), Michaël Bekaert (121005), Carmichael, Stephen N., Armin Sturm (93476), Gharbi, Karim, Bron James E., Bakaert, Michaël   +57 more
core   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

rSNPBase 3.0: an updated database of SNP-related regulatory elements, element-gene pairs and SNP-based gene regulatory networks [PDF]

, 2017
Here, we present the updated rSNPBase 3.0 database (http://rsnp3.psych.ac.cn), which provides human SNP-related regulatory elements, element-gene pairs and SNP-based regulatory networks.
Jing Wang, Liyuan Guo, Guo, Liyuan, Wang, Jing   +3 more
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

SNP-ID and primer sequences of selected breed-specific SNPs of Polish HF cattle. [PDF]

, 2016
SNP-ID and primer sequences of selected breed-specific SNPs of Polish HF cattle.
Paweł Błaszczyk (3110316), Leyland Fraser (3110304), Haja N. Kadarmideen (419115), Przemysław Sobiech (3110313), Lech Zwierzchowski (3110298), Yaping Feng (427666), Krzysztof Wąsowicz (3110310), Dibyendu Kumar (3110295), Magdalena Ogluszka (3110286), Mariusz Pierzchała (3110292), Paulina Walendzik (3110274), Chandra Shekhar Pareek (3110277), Urszula Czarnik (3110289), Brian Gelfand (3110301), Jarosław Horbańczuk (3110307), Piotr Dziuba (3110283), Agnieszka Szostak (3110271), Marcin Sikora (2706196), Rafał Smoczyński (3110280), Tomasz Grzybowski (103542)   +19 more
core   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

SNP-SNP Interaction Analysis on Soybean Oil Content under Multi-Environments. [PDF]

, 2016
Soybean oil content is one of main quality traits. In this study, we used the multifactor dimensionality reduction (MDR) method and a soybean high-density genetic map including 5,308 markers to identify stable single nucleotide polymorphism (SNP)-SNP ...
Zhanguo Zhang (3138240), Guohua Hu (582862), Zhongqiu Ni, Zhaoming Qi (613782), Dawei Xin, Chunyan Liu, Rongsheng Zhu (613783), Xinrui Mao, Zhongqiu Ni (821942), Hongwei Jiang, Chunyan Liu (44864), Qingshan Chen, Rongsheng Zhu, Huiying Jia (2457178), Xue Han (25073), Xue Han, Zhaoming Qi, Zhenbang Hu, Zhengong Yin (3138228), Zhenbang Hu (2550814), Dawei Xin (613784), Xiaoxia Wu, Zhanguo Zhang, Huiying Jia, Yue Leng, Zhengong Yin, Hongxiao Yu, Qingshan Chen (528259), Yue Leng (3138237), Xinrui Mao (3138231), Shanshan Jiang (382941), Hongwei Jiang (402234), Guohua Hu, Hongxiao Yu (3138234), Shanshan Jiang, Xiaoxia Wu (671551)   +35 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source