Results 131 to 140 of about 593,238 (360)

Set-Based Tests for Genetic Association Using the Generalized Berk-Jones Statistic [PDF]

arXiv, 2017
Studying the effects of groups of Single Nucleotide Polymorphisms (SNPs), as in a gene, genetic pathway, or network, can provide novel insight into complex diseases, above that which can be gleaned from studying SNPs individually. Common challenges in set-based genetic association testing include weak effect sizes, correlation between SNPs in a SNP-set,
arxiv  

Functional consequence of the MET-T1010I polymorphism in breast cancer. [PDF]

, 2014
Major breast cancer predisposition genes, only account for approximately 30% of high-risk breast cancer families and only explain 15% of breast cancer familial relative risk.
Brown, Powel H, Chavez-MacGregor, Mariana, Chen, Ken, Eterovic, Agda K, Gagea, Mihai, Gonzalez-Angulo, Ana M, Hortobagyi, Gabriel N, Lei, Xiudong, Liu, Shuying, Mendelsohn, John, Meric-Bernstam, Funda, Mills, Gordon B, Nair, Lakshmy, Parinyanitikul, Napa, Tripathy, Debu, Ueno, Naoto T, Wang, Bailiang, Zheng, Xiaofeng, Zhou, Wanding   +18 more
core   +2 more sources

Genomic and Cis‐Regulatory Basis of a Plastic C3‐C4 Photosynthesis in Eleocharis Baldwinii

Advanced Science, EarlyView.
The sedge Eleocharis baldwinii remarkably switches between C3‐like and C4‐like photosynthesis in response to environmental conditions. Combining gap‐free genome assembly with single‐cell multi‐omics, this study uncovers how subgenome dominance and cell‐specific cis‐regulation enable C4 photosynthesis.
Lu Chen, Yanfeng Jia, Zaihui Zhou, Qiying Jiang, Jianlin Liu, Jianhui Gu, Chuan Chen, Shujing Cheng, Jinfang Chu, Xin Liu, Yongjun Lin, Xiang Li   +11 more
wiley   +1 more source

Bayesian Model Comparison in Genetic Association Analysis: Linear Mixed Modeling and SNP Set Testing [PDF]

, 2015
We consider the problems of hypothesis testing and model comparison under a flexible Bayesian linear regression model whose formulation is closely connected with the linear mixed effect model and the parametric models for SNP set analysis in genetic ...
Wen, Xiaoquan
core  

Liberators of NO exert a dual effect on renin secretion from isolated mouse renal juxtaglomerular cells [PDF]

, 1993
This study aimed to examine the role of nitric oxide (NO) in the regulation of renin secretion from renal juxtaglomerular (JG) cells. Using primary cultures of mouse renal JG cells, we found that sodium nitroprusside (SNP) and 3-morpholino-sydnonimin ...
Kurtz, Armin, Schricker, K.
core   +1 more source

JA‐Mediated Regulation of Amino Acid Homeostasis Adjusts Metabolic Flux and Enhances Spider Mite Tolerance via the SlJAZ8‐SlWRKY57‐SlAVT6s Module in Tomato

Advanced Science, EarlyView.
This study elucidates a novel SlJAZ8‐SlWRKY57‐SlAVT6A/SlAVT6B module that effectively channels metabolic flux from primary to secondary metabolism, impacting plant growth, development, and resistance. Two novel vacuolar amino acid exporters, SlAVT6A and SlAVT6B, fine‐tunes trichomes, terpenes, and gibberellins, bolstering spider mite resistance.
Yingchen Hao, Xiaolong Wang, Langchen Guo, Lijun Xiang, Enxi Luo, Peng Cao, Penghui Liu, Yue Zhong, Chun Li, Jun Lai, Jun Yang, Shouchuang Wang   +11 more
wiley   +1 more source

Simultaneous Selection of Multiple Important Single Nucleotide Polymorphisms in Familial Genome Wide Association Studies Data

, 2018
We propose a resampling-based fast variable selection technique for selecting important Single Nucleotide Polymorphisms (SNP) in multi-marker mixed effect models used in twin studies. Due to computational complexity, current practice includes testing the
Basu, Saonli, Chatterjee, Snigdhansu, Majumdar, Subhabrata, McGue, Matt   +3 more
core   +1 more source

A reference haplotype panel for genome-wide imputation of short tandem repeats. [PDF]

, 2018
Short tandem repeats (STRs) are involved in dozens of Mendelian disorders and have been implicated in complex traits. However, genotyping arrays used in genome-wide association studies focus on single nucleotide polymorphisms (SNPs) and do not readily ...
Fotsing, Stephanie Feupe, Gymrek, Melissa, Mitra, Ileena, Mousavi, Nima, Saini, Shubham   +4 more
core   +3 more sources

Accounting for ALA Natural Mutations Enhances the Efficiency of Graphene Oxide Nanopriming in Bar‐Modified Arabidopsis

Advanced Science, EarlyView.
Nanopriming enhances plant resilience to environmental challenges; however, its effectiveness across diverse genetic backgrounds, including genetic modifications and natural variations, remains uncertain. These findings demonstrate that nanopriming improves efficacy when natural genetic variations are considered, particularly in genetically modified ...
Yining Wu, Rui Sun, Yueting Cui, Jun Qiao, Chengdong Zhang   +4 more
wiley   +1 more source

A Multi-Biomarker Approach to Increase the Accuracy of Diagnosis and Management of Coronary Artery Disease

Journal of Cardiovascular Development and Disease
Non-invasive possibilities of predicting cardiovascular risk and monitoring the treatment and progression of coronary artery disease (CAD) are important subjects of cardiovascular research.
Lenka Hostačná, Jana Mašlanková, Dominik Pella, Beáta Hubková, Mária Mareková, Daniel Pella   +5 more
doaj   +1 more source