Results 11 to 20 of about 815,442 (374)
PTPN2 gene variants are associated with susceptibility to both Crohn's disease and ulcerative colitis supporting a common genetic disease background. [PDF]
, 2012 Genome-wide association studies identified PTPN2 (protein tyrosine phosphatase, non-receptor type 2) as susceptibility gene for inflammatory bowel diseases (IBD).
Beigel, Florian +15 more
core +8 more sources
SNP+ to predict dropout rates in SNP arrays
Conservation Genetics Resources, 2022 AbstractGenotyping individuals using forensic or non-invasive samples such as hair or fecal samples increases the risk of allelic amplification failure (dropout) due to the low quality and quantity of DNA. One way to decrease genotyping errors is to increase the number of replicates per sample.
Sastre Alaiz, Natalia +2 more
openaire +3 more sources
SNP-VISTA: An interactive SNP visualization tool [PDF]
BMC Bioinformatics, 2005 Abstract Background Recent advances in sequencing technologies promise to provide a better understanding of the genetics of human disease as well as the evolution of microbial populations. Single Nucleotide Polymorphisms (SNPs) are established genetic markers that aid in the identification of loci affecting quantitative ...
Shah, Nameeta +6 more
openaire +5 more sources
Life, 2023 Osteoarthritis (OA) is the most common degenerative disease of the connective tissue of the human musculoskeletal system. Despite its widespread prevalence, there are many limitations in its diagnosis and treatment.
Marko Moravek +2 more
doaj +1 more source
SNP by SNP by environment interaction network of alcoholism [PDF]
BMC Systems Biology, 2017 Alcoholism has a strong genetic component. Twin studies have demonstrated the heritability of a large proportion of phenotypic variance of alcoholism ranging from 50-80%. The search for genetic variants associated with this complex behavior has epitomized sequence-based studies for nearly a decade. The limited success of genome-wide association studies
Zollanvari, Amin, Alterovitz, Gil
openaire +3 more sources
Stairway Plot 2: demographic history inference with folded SNP frequency spectra
Genome Biology, 2020 Inferring the demographic histories of populations has wide applications in population, ecological, and conservation genomics. We present Stairway Plot 2, a cross-platform program package for this task using SNP frequency spectra.
Xiaoming Liu, Yun-Xin Fu
semanticscholar +1 more source
SNP-SNP interactions in breast cancer susceptibility [PDF]
BMC Cancer, 2006 AbstractBackgroundBreast cancer predisposition genes identified to date (e.g., BRCA1 and BRCA2) are responsible for less than 5% of all breast cancer cases. Many studies have shown that the cancer risks associated with individual commonly occurring single nucleotide polymorphisms (SNPs) are incremental.
Onay, Venüs Ü +9 more
openaire +4 more sources
NABIC SNP: an integrated database for SNP markers [PDF]
Bioinformation, 2015 The National Agricultural Biotechnology Information Center (NABIC) constructed a web-based database to provide information about 54,310 single nucleotide polymorphisms (SNPs) identified in the seven species in a high-throughput manner. The database consists of three major functional categories: SNP marker search, detailed information viewer and ...
Kim, Chang-Kug +3 more
openaire +2 more sources
PLoS ONE, 2012 The ability to efficiently and accurately determine genotypes is a keystone technology in modern genetics, crucial to studies ranging from clinical diagnostics, to genotype-phenotype association, to reconstruction of ancestry and the detection of ...
Brant Peterson +4 more
semanticscholar +1 more source
Serum cholesterol is a significant and independent mortality predictor in liver cirrhosis patients
Annals of Hepatology, 2013 Background and Aim. Accurate assessment of cirrhotic patient’s prognosis is essential for decisions regarding the course of treatment. Therefore we aimed to confirm and quantify the predictive value of serum cholesterol and serum triglycerides in liver ...
Martin Janičko +3 more
doaj +1 more source