Results 121 to 130 of about 23,427,651 (311)
Exhaustive search of the SNP-SNP interactome identifies epistatic effects on brain volume in two cohorts [PDF]
, 2013 The SNP-SNP interactome has rarely been explored in the context of neuroimaging genetics mainly due to the complexity of conducting ∼10 11 pairwise statistical tests.Nicholas G. Martin, Katie L. McMahon, Michael W. Weiner, Jahanshad, Neda, Montgomery, Grant W., Stein, J.L., de Zubicaray, G.I., Weiner, M.W., de Zubicaray, Greig I., Wright, M.J., Wright, Margaret J, Weiner, Michael W., Greig I. de Zubicaray, Montgomery, Grant W, Kohannim, Omid, Thompson, Paul M., Weiner, Michael W, Martin, Nicholas G, McMahon, Katie L., Neda Jahanshad, Martin, N.G., Omid Kohannim, Stein, Jason L., Montgomery, G.W., McMahon, K.L., Arthur W. Toga, Thompson, Paul M, Hibar, Derrek P., Grant W. Montgomery, Toga, Arthur W., Wright, Margaret J., Thompson, P.M., Hibar, Derrek P, Jahanshad, N., Stein, Jason L, de Zubicaray, Greig I, Hibar, D.P., Martin, Nicholas G., Toga, Arthur W, McMahon, Katie L, Toga, A.W., Kohannim, O., Derrek P. Hibar, Jason L. Stein, Margaret J. Wright, Paul M. Thompson +45 morecore +2 more sourcesCausalCellInfer: Prioritizing Cell‐Type‐Specific Disease Associations From Genetically Predicted Transcriptomes in Biobank Cohorts
Advanced Science, EarlyView.Bulk and genotype‐imputed transcriptomes obscure the cellular drivers of complex disease. CausalCellInfer resolves them by integrating invariant marker selection, deep learning deconvolution, and regularized matrix completion. Applied to ∼500 000 UK Biobank participants across 29 traits, it uncovers hallmark cell‐type proportion shifts, including ...Liangying Yin, Yujia Shi, Ruoyu Zhang, Yong Xiang, Jinghong Qiu, Pak‐Chung Sham, Hon‐Cheong So +6 morewiley +1 more sourceStructural Variants in the Human Genome Associated With Gut Microbiome and Blood Metabolic Traits With Potential Causal Links
Advanced Science, EarlyView.Based on a multi‐omics cohort of 2002 individuals comprising high‐depth whole‐genome and metagenomic sequencing data, blood metabolites, and detailed questionnaires, we identified 138 859 high‐confidence SVs, uncovering 36 significant SV–microbiome associations and 48 SV–blood metabolite associations.Qun Zhou, Keqing Wang, Junhong Chen, Haoyu Wang, Xinjiang Tan, Xuanlin Huang, Zhiyin Lin, Xun Xu, Xin Jin, Shaoqiao Zhang, Liang Xiao, Yuanqiang Zou, Tao Zhang, Xiaomin Liu +13 morewiley +1 more sourceAnalysis of snp-snp Interactions among rs3825214, rs7312625 and rs8830799 and Their Association with AF.
, 2016 Analysis of snp-snp Interactions among rs3825214, rs7312625 and rs8830799 and Their Association with AF.Xiaochen Tian (585595), Yingxue Dong (2901182), Yanzong Yang (470518), Rongfeng Zhang (585594), Huihua Li (166588), Lianjun Gao (470517), Xiaomeng Yin (2901185), Yunlong Xia (470516) +7 morecore +1 more sourceAge‐Related Lamin B1 Deficiency Activates SLC7A11‐Dependent Disulfidptosis to Impair Osteogenesis via Intercepting Mitochondrial Fission
Advanced Science, EarlyView.This study reveals that age‐related LMNB1 deficiency in mesenchymal stem cells epigenetically upregulates SLC7A11, triggering actin disulfidptosis and mitochondrial dysfunction. This cascade impairs bone formation in senile osteoporosis. Furthermore, researchers identified the FDA‐approved drug naldemedine as a targeted SLC7A11 inhibitor to reverse ...Wenhui Yu, Qibo Li, Weihao Zhang, Guan Zheng, Junhua Chen, Yipeng Zeng, Zipeng Xiao, Zibin Chen, Ziqian Liu, Yangfeng Lin, Jiajie Lin, Zepeng Su, Zhongyu Xie +12 morewiley +1 more sourceSNP-specific genotype frequencies for cases (YWC) and controls (CGEMS).
, 2019 SNP-specific genotype frequencies for cases (YWC) and controls (CGEMS).Bryce G. Larson (6733730), Penelope Miron (171974), Laura C. Collins (416928), Kathryn J. Ruddy (5391302), Elena Brachtel (5044052), Meghan E. Meyer (6733727), Virginia Borges (5809064), Qiyuan Li (236147), Ji-Heui Seo (6733733), Hilde Vardeh (2922144), Michelle Rath (6733721), Mark Pomerantz (260848), Matthew Freedman (23592), Rulla M. Tamimi (437781), Anne E. Dowton (6733724), Lidia Schapira (549257), Sara Lindström (120789), Alexander Miron (28179), Ann H. Partridge (5249723), Huili Li (357603), Steven E. Come (416933) +20 morecore +1 more sourceCRISPR‐Scan: Cas13a Mismatch Tolerance Enabled Ultra‐Multiplexed Detection of Same‐Site Indels in Acute Myeloid Leukemia
Advanced Science, EarlyView.Accurately detecting diverse same‐locus insertions or deletions (indels) remains challenging. This study reveals the mismatch‐tolerance profile of LwaCas13a and establishes CRISPR‐Scan, which uses a single crRNA to detect multiple same‐locus indels. The one‐pot assay detects nucleophosmin 1 (NPM1) mutant allele frequencies down to 0.01%, agrees with ...Linlin Bai, Bei Wang, Mingmin Shi, Dianwei Liu, Huimin Ji, Ting Wang, Ziwei Wang, Kaiming Guo, Xinyang Dou, Chunyan Qian, Fang Zhang, Yongming Wang, Hongju Mao, Rui Wang +13 morewiley +1 more sourcengs-snp-pipeline-v3.2
, 2012 nuclear locus assembly and SNP discovery pipeline R ...Peter H. Dutton (163010), Amy Frey (3261387), Archer, Frederick I., Hancock-Hanser, Brittany, Phillip A. Morin (198405), Frederick I. Archer (198398), Leslie, Matthew S., Dutton, Peter H., Matthew S. Leslie (370104), Morin, Phillip A., Brittany Hancock-Hanser (178889), Frey, Amy +11 morecore +1 more sourceGapless Complete Genome and Multi‐Omics Illuminate Immune Adaptation and Host‐Virus Interactions in a Coronavirus Reservoir
Advanced Science, EarlyView.We present a complete T2T genome assembly for a key bat reservoir. Integrating population genomics, comparative genomics, transcriptomics, single‐cell omics, and functional assays, we resolve previously inaccessible genomic regions and identify evolutionary signatures associated with immune adaptation.Yuting Wang, Sheng Zhang, Linxia Ouyang, Xin Du, Xin Huang, Zhilin Wang, Huixian Xie, Jiale Tang, Liyi Lou, Wenqing Ling, Weihao Wang, Jiang Zhou, Zhen Liu, Yibo Hu, Fuwen Wei, Guangping Huang +15 morewiley +1 more sourceGenetic susceptibility of IKZF1, ARID5B, and CEBPE polymorphisms to childhood acute lymphoblastic leukemia in Chinese populations: a case-control study
Global Medical GeneticsObjective: This study aimed to evaluate the association of single nucleotide polymorphisms (SNPs) in IKZF1, ARID5B, and CEBPE with acute lymphoblastic leukemia (ALL) susceptibility in Chinese children.Xiaoqing Cao, Yong Wang, Yurou Kang, Muhammad Usman Abubakar, Yanli Yang, Daihua Fang, Bangshun He +6 moredoaj +1 more source
