Results 181 to 190 of about 83,042 (297)

AMPK‐mediated prevention of vascular dysfunction with metformin: Experimental and population‐based evidence

British Journal of Pharmacology, EarlyView.
Angiotensin II induces vascular inflammation, senescence, extracellular matrix (ECM) degradation and endothelial dysfunction, thus impairing SK+/IK+ channel function and reducing endothelial‐dependent hyperpolarisation (EDH). Metformin activates AMPK, increasing SK+/IK+ channel function and restoring vasorelaxation.
Soroush Mohammadi Jouabadi, Annika A. Jüttner, Annique Claringbould, Rene de Vries, Ingrid M. Garrelds, Usha Musterd‐Bhaggoe, Bruno H. Stricker, Maryam Kavousi, A. H. Jan Danser, Fariba Ahmadizar, Anton J. M. Roks   +10 more
wiley   +1 more source

Design and Application of a Genome-Wide SNP Array to Improve Conservation Outcomes in the Critically Endangered Southern Corroboree Frog. [PDF]

Mol Ecol Resour
Davidson MJ, Zenger KR, Keogh JS, Berger L, Skerratt LF, Kosch TA.   +5 more
europepmc   +1 more source

Development and application of a 10 K low-density whole-genome SNP array for chickens. [PDF]

Poult Sci
Ma X, Chen Y, Wang M, Bai L, Zheng M, Zhao G, Wen J, Liu R.   +7 more
europepmc   +1 more source

Budding speciation, mitochondrial capture and introgression between surface and cave lineages in the Asellus aquaticus species complex

Cladistics, EarlyView.
Abstract Replicated pairs of ancestral and evolutionarily derived populations provide opportunities to test hypotheses about the deterministic laws of evolution. The Asellus aquaticus species complex is an invertebrate model system with several independent surface‐to‐cave transitions and a complicated and unresolved evolutionary history.
Peter Trontelj, Valerija Zakšek, Anja Palandačić, Hans Recknagel   +3 more
wiley   +1 more source

Exploring Genomic Variability in the Mediterranean Buffalo Breed: A Step Towards Custom SNP Array. [PDF]

Animals (Basel)
Arcuri C, Gabbianelli F, Bencivenga F, Porcai G, Pietrucci D, Picarone L, Vignali G, Toscano E, Di Maggio F, Sepe L, Nunziato M, Manunza A, Lazzari B, Cozzi P, Rizzo F, Weisz A, Smal M, Biffani S, Castiglioni B, Paolella G, Salvatore F, Rullo A, Rubinacci S, Cosenza G, Carpio MG, Cimmino R, Di Vuolo G, Iannuzzi L, Milanesi M, Chillemi G.   +29 more
europepmc   +1 more source

A multiplexed plant-animal SNP array for selective breeding and species conservation applications. [PDF]

G3 (Bethesda), 2023
Montanari S, Deng C, Koot E, Bassil NV, Zurn JD, Morrison-Whittle P, Worthington ML, Aryal R, Ashrafi H, Pradelles J, Wellenreuther M, Chagné D.   +11 more
europepmc   +1 more source

Harnessing Polygenic Risk Scores to Refine Venous Thromboembolism Risk Stratification

European Journal of Haematology, EarlyView.
ABSTRACT Background Venous thromboembolism (VTE) is a major cause of morbidity in patients of all ages. Despite growing interest in polygenic risk scores (PRS) for VTE, their utility remains understudied. Our objective was to evaluate the independent impact of a PRS on VTE susceptibility in adults and children.
Katlyn G. McKay, Oliver S. Zhao, Samaya S. Badrieh, Lisa Bastarache, Xinnan Niu, Jing He, Prince J. Kannankeril, Jamie R. Robinson   +7 more
wiley   +1 more source

An advanced genotyping tool to inspect grapevine variability: the Axiom^®Vitis22K SNP array. [PDF]

Front Plant Sci
Costantini L, Micheletti D, Bettinelli P, Minio A, Spina L, Nicolini D, Troggio M, Cantù D, Vezzulli S, Bianco L.   +9 more
europepmc   +1 more source

Characteristics and mechanisms of mosaicism in prenatal diagnosis cases by application of SNP array. [PDF]

Mol Cytogenet, 2023
Zhou L, Li H, Xu C, Xu X, Zheng Z, Tang S.   +5 more
europepmc   +1 more source

Preimplantation Genetic Testing for Families at Risk of Haemophilia: Ten‐Year Single‐Centre Experience

Haemophilia, EarlyView.
ABSTRACT Introduction Preimplantation genetic testing for monogenic diseases (PGT‐M) is a reproductive option for couples at high risk of transmitting inherited disorders. We report a ten‐year single‐centre PGT‐M experience in families at risk of hemophilia.
Mimosa Mortarino, Isabella Garagiola, Valeria Nicotra, Alessandra Riccaboni, Cristina Guarneri, Edgardo Somigliana, Flora Peyvandi   +6 more
wiley   +1 more source