Results 51 to 60 of about 75,225 (256)

FUCA2 Sustains AKT Signaling and Suppresses Senescence by Antagonizing FUT3‐Mediated ErbB3 Fucosylation in Lung Adenocarcinoma

Advanced Science, EarlyView.
ABSTRACT While targeted therapies have improved outcomes in lung adenocarcinoma (LUAD), many patients still lack targetable mutations. Here, we identified alpha‐L‐fucosidase 2 (FUCA2) as a crucial driver of LUAD by preventing cellular senescence. Mechanistically, through the restriction of fucosyltransferase 3 (FUT3)‐mediated α‐1,3‐fucosylation of ...
Lu Chen, Jintao Guo, Fei Li, Mingjie Gao, Runyang Li, Zhaozhang Huang, Yaolin Zheng, Chunyi Gao, Jihuan Hou, Qiang Yu, Bowen Zheng, Xuemei Chen, Wenqing Zhang, Xiaoting Hong, Yali Zheng, Daxuan Wang, Qiyuan Li, Tianhui Hu, Yan‐yan Zhan   +18 more
wiley   +1 more source

Development and validation of a Pacific Abalone (Haliotis discus hannai) custom 60K SNP array

Aquaculture Reports
The Pacific abalone (Haliotis discus hannai) is a commercially important abalone species native to South Korea, which is immensely popular as a seafood delicacy.
Jeong Woen Shin, Sangwon Yoon, Seung Hwan Lee, Jung-Youn Park, Jong-Won Park, Hyun-Chul Kim, Woo-Jin Kim, Young-Ok Kim, Dongwon Seo, Eun Soo Noh   +9 more
doaj   +1 more source

Large SNP arrays for genotyping in crop plants

Journal of Biosciences, 2012
Genotyping with large numbers of molecular markers is now an indispensable tool within plant genetics and breeding. Especially through the identification of large numbers of single nucleotide polymorphism (SNP) markers using the novel high-throughput sequencing technologies, it is now possible to reliably identify many thousands of SNPs at many ...
Martin W, Ganal, Andreas, Polley, Eva-Maria, Graner, Joerg, Plieske, Ralf, Wieseke, Hartmut, Luerssen, Gregor, Durstewitz   +6 more
openaire   +2 more sources

Arrayed Primer Extension in the “Array of Arrays” Format: A Rational Approach for Microarray-Based SNP Genotyping [PDF]

Genetic Testing, 2007
This study provides a new version of the arrayed primer extension (APEX) protocol adapted to the 'array of arrays' platform using an instrumental setup for microarray processing not previously described. The primary aim of the study is to implement a system for rational cost-efficient genotyping where multiple singlenucleotide polymorphisms (SNPs) and ...
Klito, N, Tan, Q, Nyegaard, M, Brusgaard, K, Thomassen, M, Skouboe, C, Dahlgaard, Jesper; id_orcid 0000-0002-1798-6799, Kruse, TA   +7 more
openaire   +3 more sources

Cross‐Modal Denoising and Integration of Spatial Multi‐Omics Data with CANDIES

Advanced Science, EarlyView.
In this paper, we introduce CANDIES, which leverages a conditional diffusion model and contrastive learning to effectively denoise and integrate spatial multi‐omics data. We conduct extensive evaluations on diverse synthetic and real datasets, CANDIES shows superior performance on various downstream tasks, including denoising, spatial domain ...
Ye Liu, Wanpeng Zou, Yuekai Li, Jiayi Wang, Mingxuan Cai, Hongmin Cai   +5 more
wiley   +1 more source

Application of single nucleotide polymorphism array (SNP array) derived median copy number state for monitoring the clonal burden of the chromosomal aberrations in myelodysplastic neoplasms

Hematology
Objectives Our study integrates SNP array and metaphase cytogenetics (MC) to decode clonal architecture in myelodysplastic syndromes (MDS) and related disorders.Methods We retrospectively analyzed chromosomal aberrations in 33 patients diagnosed with MDS
Lili Song, Zhenxiu Guo, Kun Chi
doaj   +1 more source

Combined array-comparative genomic hybridization and single-nucleotide polymorphism-loss of heterozygosity analysis reveals complex genetic alterations in cervical cancer

BMC Genomics, 2007
Background Cervical carcinoma develops as a result of multiple genetic alterations. Different studies investigated genomic alterations in cervical cancer mainly by means of metaphase comparative genomic hybridization (mCGH) and microsatellite marker ...
Kenter Gemma G, Gorter Arko, Knijnenburg Jeroen, Szuhai Karoly, van Wezel Tom, Oosting Jan, Kloth Judith N, Fleuren Gert, Jordanova Ekaterina S   +8 more
doaj   +1 more source

Tumor Touch Imprints as Source for Whole Genome Analysis of Neuroblastoma Tumors. [PDF]

PLoS ONE, 2016
INTRODUCTION:Tumor touch imprints (TTIs) are routinely used for the molecular diagnosis of neuroblastomas by interphase fluorescence in-situ hybridization (I-FISH).
Clemens Brunner, Bettina Brunner-Herglotz, Andrea Ziegler, Christian Frech, Gabriele Amann, Ruth Ladenstein, Inge M Ambros, Peter F Ambros   +7 more
doaj   +1 more source

Introgressed Variation in TaMYB7‐A1 Drives Graded Dormancy and Climate‐Adaptive Pre‐Harvest Sprouting Resistance in Wheat

Advanced Science, EarlyView.
TaMYB7‐A1 directly activates TaABI5 to enhance ABA signaling and regulate ABA‐GA homeostasis, enforcing seed dormancy. Its superior allele, derived from wild einkorn introgression, harbors a MITE insertion that elevates expression and two amino acid substitutions that enhance transcriptional activity, collectively generating graded PHS resistance for ...
Hao Wang, Dongzhi Wang, Yafei Guo, Qi Zheng, Min Zhang, James Simmonds, Jian Hou, Xuemei Liu, Xuelei Lin, Xiaomin Bie, Xiansheng Zhang, Xiaohui Li, Yuan Chen, Xueyong Zhang, Cristobal Uauy, Fei Lu, Chengcai Chu, Zhixi Tian, Jun Xiao   +18 more
wiley   +1 more source

Genetic Relatedness and Heterotic Grouping in MRIZP Elite Maize Inbred Lines Using SNP Markers from 25k SNP Array and RNA-seq Data

Current Issues in Molecular Biology
Knowledge of population structure and genetic relationship among inbred lines is essential for exploiting heterosis in maize breeding programs. This study evaluated the concordance between 25k Illumina® Infinum Maize SNP (Single Nucleotide Polymorphism ...
Marko Mladenović, Bojana Banović Đeri, Ana Nikolić, Dragana Dudić, Slaven Prodanović, Sanja Z. Perić, Nikola Grčić   +6 more
doaj   +1 more source