Results 161 to 170 of about 219,632 (346)

Results of logistic regression for the 32 genotyped SNPs.

open access: green, 2015
Reedik Mägi   +10 more
openalex   +2 more sources

Evaluation of gene editing in CHO cells using the Cas‐CLOVER system

open access: yesBiotechnology Progress, EarlyView.
Abstract Recent advances in gene editing technologies have transformed the genetic engineering of Chinese hamster ovary (CHO) hosts, enabling the development of cell lines with improved stability and productivity. In this study, we employed the programmable nuclease (PN) Cas‐CLOVER to precisely target the Glutamine synthetase (GS) locus in CHO cells. A
Tiffany McLamarrah   +13 more
wiley   +1 more source

Genotype and allele frequencies of thirty-two SNPs in the ARHGAP18 gene of schizophrenia patients and controls.

open access: green, 2017
Weiyun Guo   +10 more
openalex   +2 more sources

Sequential, chromosome‐specific glutamine synthetase double knockout with Cas‐CLOVER establishes enhanced CHO platforms for cell line development

open access: yesBiotechnology Progress, EarlyView.
This study established the first creation of a commercially available double GS knockout (DKO) from a single KO in CHO‐K1 cells, called CleanCut GS CHO using Cas‐CLOVER. When combined with the Harbor‐IN transposase system, CleanCut GS CHO cells demonstrated a highly antibody productivity.
Cintia Gomez Limia   +7 more
wiley   +1 more source

Employing genome-wide SNP discovery and genotyping strategy to extrapolate the natural allelic diversity and domestication patterns in chickpea [PDF]

open access: gold, 2015
Alice Kujur   +14 more
openalex   +1 more source

Predicting cervical cancer DNA methylation from genetic data using multivariate CMMP

open access: yesCanadian Journal of Statistics, EarlyView.
Abstract Epigenetic modifications link the environment to gene expression and play a crucial role in tumour development. DNA methylation, in particular, is gaining attention in cancer research, including cervical cancer, the focus of this study.
Hang Zhang   +5 more
wiley   +1 more source

Pharmacogenomics of Major Depressive Disorder in Indigenous Amazonian Populations

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Major depressive disorder is a highly prevalent psychological disorder worldwide and its main treatment is the use of Selective Serotonin Reuptake Inhibitors. However, few studies have demonstrated the relationship between the presence of genetic variants in pharmacogenes and the efficacy of these drugs, especially in populations with a unique genetic ...
Kaio Evandro Cardoso Aguiar   +9 more
wiley   +1 more source

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