Results 91 to 100 of about 524,252 (269)

Photo‐Controlled Antibacterial Drug Release From DASA‐Coated Silica Particles for Improved Treatment of Wound Infections

Advanced Functional Materials, EarlyView.
Synthesis and characterization of light‐responsive donor–acceptor Stenhouse adducts (DASA)‐coated chlorhexidine‐loaded silica nanoparticles. Such a controllable drug‐delivery system enables the release of the antimicrobial drug on demand and in consecutive cycles, thereby maintaining the concentration within the therapeutic window.
Michèle Clerc, Flavia Zuber, Lea Oberhänsli, Yvonne Elbs‐Glatz, Maria M. Miguel, Vera M. Kissling, Qun Ren, Markus Rottmar, Luciano F. Boesel, Giorgia Giovannini   +9 more
wiley   +1 more source

A novel locus in CSMD1 gene is associated with increased susceptibility to severe malaria in Malian children

Frontiers in Genetics
BackgroundPlasmodium falciparum malaria is still a leading cause of child mortality in sub-Saharan Africa. The clinical manifestations of malaria range from asymptomatic infection to severe disease.
Delesa Damena, Amadou Barry, Robert Morrison, Santara Gaoussou, Almahamoudou Mahamar, Oumar Attaher, Djibrilla Issiaka, Yahia Dicko, Alassane Dicko, Patrick Duffy, Michal Fried   +10 more
doaj   +1 more source

SIGNIFICANCE OF SINGLE-NUCLEOTIDE POLYMORPHISMS 2578C>A AND +936C>T IN THE VEGF GENE FOR EFFICIENCY EVALUAT ION OF ANTICANCER IMMUNOTHERAPY IN PAT IENTS WITH METASTAT IC SKIN MELANOMA

Медицинская иммунология, 2014
. Increased VEGF levels in cancer patients may be associated with decreased number of dendritic cells (DCs) and lower DC function. We investigated whether VEGF gene polymorphisms -2578C>A (rs699947) and +936C>T (rs3025039) are associated with ...
Yu. A. Khochenkova, G. Z. Chkadua, I. V. Samoylenko, T. F. Malivanova, I. N. Mikhailova, L. V. Demidov, E. V. Stepanova   +6 more
doaj   +1 more source

Improving sequence-based genotype calls with linkage disequilibrium and pedigree information

, 2012
Whole and targeted sequencing of human genomes is a promising, increasingly feasible tool for discovering genetic contributions to risk of complex diseases.
Whittemore, Alice S., Zhou, Baiyu
core   +1 more source

Oxygen Supply of Islets of Langerhans by Photosynthetically Active Microalgae in Bioprinted Co‐Cultures Maintains Their Function in a Hypoxic Environment

Advanced Healthcare Materials, EarlyView.
This study developed a bioprinted co‐culture system embedding rat pancreatic islets and Scenedesmus sp. microalgae spatially defined in close vicinity. Red light was found optimal to ensure microalgal photosynthesis while maintaining islet viability and functionality. A tailored co‐culture medium supported both cell types.
Finn Dani, Sarah Duin, Ashwini Rahul Akkineni, Susann Lehmann, Barbara Ludwig, Michael Kühl, Michael Gelinsky, Anja Lode   +7 more
wiley   +1 more source

Integrated Transcriptomics Reveals Evolutionary Trajectories and Cell Density‐Dependent Mechanisms in Aldosterone‐Producing Adenomas

Advanced Science, EarlyView.
Aldosterone‐producing adenomas (APAs) develop via two distinct paths: directly from adrenal zona glomerulosa (zG) cells, or stepwise from zG cells through aldosterone‐producing micronodules (APMs) before progressing to APAs. Advanced single‐cell and spatial analyses identified distinct cell states linked to oxidative stress and cell–cell interactions ...
Zhuolun Sun, Changying Jing, Martina Tetti, Siyuan Gong, Jia Wei, Yingxian Pang, Martin Reincke, Tracy Ann Williams   +7 more
wiley   +1 more source

Developing Single Nucleotide Polymorphisms for Identification of Cod Products by RAD-Seq

Animals, 2020
The increase in the rate of seafood fraud, particularly in the expensive fishes, forces us to verify the identity of marine products. Meanwhile, the definition of cod lacks consistency at the international level, as few standards and effective ...
Shoujia Jiang, Xingyu Ma, Tao Li, Changqing Zhu, Xinxin You   +4 more
doaj   +1 more source

Thermal Plasticity is Regulated by a Key MicroRNA During Range Expansion of an Invasive Fruit Fly

Advanced Science, EarlyView.
Populations at the invasion front of Bactrocera dorsalis adapt through reduced phenotypic and gene expression plasticity, a phenomenon likely to be driven by genetic assimilation. We identify a key miRNA‐mediated regulatory axis, in which miR‐276b post‐transcriptionally represses thw, a conserved chitin‐binding gene critical to the cold‐tolerance ...
Yan Zhao, Juntao Hu, Juan Du, Shaokun Guo, Youming Hou, Zhihong Li   +5 more
wiley   +1 more source

Telomere‐to‐Telomere Genomes Reveal that Multiscale Evolution Shapes the Largest Metabolic Arsenal of Diaporthe Fungi

Advanced Science, EarlyView.
This study presents the first telomere‐to‐telomere genomes and population resources for Diaporthe pathogens, uncovering the largest known fungal repertoire of secondary metabolite gene clusters. Structural variations and horizontal gene transfer drive cluster diversification, while specific rapidly evolving clusters control virulence, offering novel ...
Kainan Li, Chen Zhang, Zhichao Zhang, Jiaheng Cheng, Qiuyan Gao, Long Gao, Xiaolin Zhao, Wei Yan, Yuanchao Wang, Wenwu Ye   +9 more
wiley   +1 more source

Population genetic structure, linkage disequilibrium and effective population size of conserved and extensively raised village chicken populations of Southern Africa

Frontiers in Genetics, 2015
Extensively raised village chickens are considered a valuable source of biodiversity, with genetic variability developed over thousands of years that ought to be characterised and utilized.
Khulekhani Sedwell Khanyile, Khulekhani Sedwell Khanyile, Edgar Farai Dzomba, Farai Catherine Muchadeyi   +3 more
doaj   +1 more source