Results 71 to 80 of about 384,456 (306)

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Human platelet antigen polymorphisms and the risk of chronic Chagas disease cardiomyopathy

Platelets, 2020
Human platelet antigen (HPA) polymorphisms are considered to be a risk factor for cardiac and vascular diseases, but the role of HPA in chronic Chagas disease cardiomyopathy (CCC) is not available.
Deborah Elzita do Carmo Corrêa, Christiane Maria Ayo, Jeane Eliete Laguila Visentainer, Eliane Papa Ambrosio-Albuquerque, Pâmela Guimarães Reis, Cinara Cássia Brandão de Mattos, Reinaldo Bulgarelli Bestetti, Luiz Carlos de Mattos, Ana Maria Sell   +8 more
doaj   +1 more source

Análise de polimorfismos de nucleotídeos únicos (SNPs) do gene HSP70 em populações de litopenaeus vannamei comercializadas no Brasil [PDF]

, 2014
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Agrárias, Programa de Pós-Graduação em Aqüicultura, Florianópolis, 2014.O objetivo do trabalho foi estudar a diversidade genética do gene HSP70 através da análise de SNPs
Ferreira Júnior, Augusto Luiz
core  

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Association of Candidate Single Nucleotide Polymorphisms Related to Candidate Genes in Patients With Schizophrenia

Basic and Clinical Neuroscience, 2020
Introduction: Schizophrenia is a chronic heterogenic neurodevelopment disorder. Many genes interfere in the development of SCZ. All four genes, NrCAM, PRODH, ANK3, and ANKK1, which were evaluated in this study, were previously reported to be associated ...
Seyedeh Sara Karimian, Mohammad Taghi Akbari, Seyed Saeed Sadr, Gholamreza Javadi   +3 more
doaj  

rshikha95/CHD-SNPs: v1.0.0-CHDSNPs [PDF]

<p>R Code to process SNPs from publicly available databases: an implication to congenital heart disease (CHD).</p ...
Shikha Vashisht
core   +1 more source

Genome-Wide Association Studies of the PR Interval in African Americans [PDF]

, 2011
The PR interval on the electrocardiogram reflects atrial and atrioventricular nodal conduction time. The PR interval is heritable, provides important information about arrhythmia risk, and has been suggested to differ among human races.
Paltoo, Dina N., Smith, J Gustav, Smith, J.G., Heckbert, S.R., Zonderman, Alan B., Sotoodehnia, N., Mehra, R., Susan R. Heckbert, Ellinor, Patrick T, Palmer Cameron, Elsayed Z. Soliman, Benjamin, E.J., Newman, A.B., Müller, Martina, Kerr, K.F., Pfeufer, Arne, Newman, Anne B., Soliman, Elsayed Z, Magnani, JW, Candidate-gene Association Resource (CARe) Consortium, Ellinor Patrick T., Martina Müller, Kathleen F Kerr, Kerr, Kathleen F., Liu, Yongmei, Evans, Daniel S, Zonderman, Alan B, Palmer, C., Schnabel, Renate B, J Gustav Smith, Musani, Solomon K, Michele K Evans, Alonso Alvaro, Musani, Solomon K., Alonso, A, Newman, Anne B, Renate B Schnabel, Smith, JG, Smith, Gustav,, Schnabel Renate B., Magnani, Jared W., Emelia J Benjamin, null null, Ervin R Fox, Zonderman, AB, Jared W. Magnani, Paltoo, Dina N, Ellinor, Patrick T., Schnabel, R.B., Evans, M.K., Lund University., Kerr Kathleen F., Liu, Y, Cameron Palmer, Paltoo Dina N., Meng Yan A., Fox, Ervin R, Mehra Reena, Alonso, A., Patrick T. Ellinor, Anne B Newman, Redline Susan, Nalls, MA, Ellinor, PT, Schnabel, Renate B., Redline, Susan, Ellinor, P.T., Sotoodehnia, Nona, Nalls, Michael A., Arne Pfeufer, Smith J. Gustav, Newton-Cheh, Christopher, Solomon K Musani, Redline, S, Fox, ER, Renate B. Schnabel, Evans, Michele K., Mehra, R, Heckbert, SR, Meng, Yan A, Heckbert, Susan R, Christopher Newton-Cheh, Meng, YA, Evans, DS, Ervin R. Fox, Soliman Elsayed Z., Heckbert, Susan R., Michael A Nalls, Yan A. Meng, Fox, E.R., Susan Redline, Newton-Cheh Christopher, Fox, Ervin R., Evans, Michele K, Kathleen F. Kerr, Liu Yongmei, Alvaro Alonso, Nalls Michael A., Deo, R, Musani Solomon K., Newton-Cheh, C., Alan B. Zonderman, Soliman, EZ, Lubitz, S.A., Soliman, Elsayed Z., Dina N. Paltoo, Steven A Lubitz, Lubitz, SA, Alan B Zonderman, Evans, MK, Magnani, J.W., Patrick T Ellinor, Deo Rajat, Lubitz, Steven A, Nalls, Michael A, Pfeufer, A., Meng, Y.A., Evans Michele K., Benjamin, Emelia J., Benjamin Emelia J., Pfeufer Arne, Paltoo, D.N., Smith, J. Gustav, Sotoodehnia Nona, Elsayed Z Soliman, Soliman, E.Z., Jared W Magnani, Meng, Yan A., Redline, S., Newton-Cheh, C, Benjamin, Emelia J, Zonderman Alan B., Daniel S. Evans, Müller, M, Kerr, Kathleen F, Alonso, Alvaro, Rajat Deo, Kerr, KF, Schnabel, RB, Pfeufer, A, Müller, M., Paltoo, DN, Palmer, Cameron, Nona Sotoodehnia, Solomon K. Musani, Newman Anne B., Lubitz Steven A., Yongmei Liu, Zonderman, A.B., Nalls, M.A., Musani, S.K., Deo, Rajat, Musani, SK, Evans Daniel S., Deo, R., Dina N Paltoo, Newman, AB, Michele K. Evans, Mehra, Reena, Fox Ervin R., Yan A Meng, Evans, D.S., Evans, Daniel S., Benjamin, EJ, Susan R Heckbert, Emelia J. Benjamin, J. Gustav Smith, Reena Mehra, Palmer, C, Liu, Y., Magnani, Jared W, Anne B. Newman, Smith, Gustav, Daniel S Evans, Lubitz, Steven A., Steven A. Lubitz, Michael A. Nalls, Heckbert Susan R., Magnani Jared W., Müller Martina, Sotoodehnia, N   +180 more
core   +1 more source

A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen, Ceren Tozlu, Tina Roostaei, Fatoumata Diallo, Kaho Onomichi, Jiyeon Son, Zongqi Xia, Philip L. De Jager   +7 more
wiley   +1 more source

Range-wide parallel climate-associated genomic clines in Atlantic salmon [PDF]

Royal Society Open Science, 2017
Clinal variation across replicated environmental gradients can reveal evidence of local adaptation, providing insight into the demographic and evolutionary processes that shape intraspecific diversity.
Nicholas W. Jeffery, Ryan R. E. Stanley, Brendan F. Wringe, Javier Guijarro-Sabaniel, Vincent Bourret, Louis Bernatchez, Paul Bentzen, Robert G. Beiko, John Gilbey, Marie Clément, Ian R. Bradbury   +10 more
doaj   +1 more source

stevemussmann/BayesAss3-SNPs: BA3-SNPs v1.0.2 [PDF]

, 2019
<p>Updated Readme file</p ...
Steve Mussmann
core   +1 more source