Results 81 to 90 of about 423,756 (267)

THSD7A Exacerbates Atherosclerosis via Activation of Signaling Axis αvβ3/CEBPD/IL1A

Advanced Science, EarlyView.
THSD7A exerts pro‐inflammatory effects and exacerbates atherosclerosis. Mechanistically, THSD7A regulates endothelial cell inflammation and atherosclerosis by activating the αvβ3/CEBPD/IL1A signaling axis. THSD7A is not only a genetic marker but also a potential therapeutic target for coronary artery disease (CAD).
Jiankun Liu, Hongfei Liu, Yiqi Wan, Andong Wu, Jiayu Qiu, Xueting Gong, Ya Zhao, Yuanyuan Li, Bingbing Zhou, Yangyi Zheng, Fang Wu, Yuanzheng Zhu, Weixin Lv, Xueer Li, Qiang Yuan, Xiao‐Li Tian   +15 more
wiley   +1 more source

Molecular analysis of STAT3 and their association in non-Hodgkin lymphoma incidence

Iraqi Journal of Hematology
BACKGROUND: Signal transducer and activator of transcription 3 (STAT3) is an essential transcription factor that functions through the Janus kinase/STAT signaling pathway, regulating cell proliferation, survival, tumorigenesis, immune surveillance, and ...
Basma M. Al-Sarraj, Maha Fakhry Altaee
doaj   +1 more source

DIXDC1 Promotes Lymphatic Metastasis and Resistance to Cuproptosis in Bladder Cancer Through Mediating DLAT

Advanced Science, EarlyView.
DIXDC1 drives bladder cancer progression by binding and stabilizing DLAT. This axis enhances NEK7 and CCNE2 mRNA stability to promote proliferation and lymphatic metastasis, while limiting copper‐induced DLAT oligomerization to reduce cuproptosis sensitivity, identifying DIXDC1 as a potential target linking metastasis with cuproptosis resistance ...
Hongqiong Li, Liang Cheng, Xiaole Lu, Haonan Dong, Shi Fu, Hongjin Shi, Mingsheng Liu, Chenwei Yang, Yuhang Huang, Zehua Chen, Yawei Zhang, Kaiwen Jie, Xiaoyue Zhang, Xiang Kui, Xinni Ye, Siting Chen, Xu Chen, Haifeng Wang   +17 more
wiley   +1 more source

Evaluation of the Role of Two SNPs in MTHFR Gene Polymorphisms (rs1801133) 677 C>T and (rs 1801131) 1298A>C with Homocysteine Level in Iraqi Patients with Chronic Kidney Disease [PDF]

Modern Medicine
Objectives: Objectives: The current study was designed to evaluate the role of MTHFR gene (rs1801133 and rs1801131) polymorphisms and investigate the serum Homocysteine level in Iraqi patients with CKD.
Saife AL-AHMER, Basima AL-SAADI, Ali AL SAEDI   +2 more
doaj   +1 more source

Relationship of FTO gene variations with NAFLD risk in Chinese men

Open Life Sciences, 2020
Fat mass and obesity-associated (FTO) gene is an obesity susceptibility gene and its relationship with the nonalcoholic fatty liver disease (NAFLD) remains unclear.
Chen Xuefen, Gao Yong, Yang Xiaobo, Zhang Haiying, Mo Zengnan, Tan Aihua   +5 more
doaj   +1 more source

A Genome-Wide Association Study To Understand the Effect of Fusarium verticillioides Infection on Seedlings of a Maize Diversity Panel

G3: Genes, Genomes, Genetics, 2020
Fusarium verticillioides, which causes ear, kernel and stem rots, has been reported as the most prevalent species on maize worldwide. Kernel infection by F. verticillioides results in reduced seed yield and quality as well as fumonisin contamination, and
Lorenzo Stagnati, Vahid Rahjoo, Luis F. Samayoa, James B. Holland, Virginia M. G. Borrelli, Matteo Busconi, Alessandra Lanubile, Adriano Marocco   +7 more
doaj   +1 more source

TECTB Variants Reveal Tectorial Membrane Vulnerability in Dominant Non‐Syndromic Hearing Loss

Advanced Science, EarlyView.
TECTB is a non‐collagenous protein of the tectorial membrane – an extracellular matrix of the cochlea. This study identifies dominant missense variants in TECTB linked to human hereditary deafness in two unrelated families. Genetically engineered mice homozygous for one of the variants are profoundly deaf, whereas heterozygous mice have normal hearing ...
Evan B. Hale, Barbara Vona, Richard J. Goodyear, Richard T. Osgood, Jun Shen, Sami S. Amr, Karen Mojica, Michaela A. H. Hofrichter, Jörg Schröder, Sophie Flandin, Paul Gratias, Ricardo Vera‐Monroy, Katherine Callahan, Kerry L. Gudlewski, Rolen Quadros, Masato Ohtsuka, JoAnn McGee, Edward J. Walsh, Cynthia C. Morton, Thomas Haaf, Channabasavaiah Gurumurthy, James E. Saunders, Guy P. Richardson, Artur A. Indzhykulian   +23 more
wiley   +1 more source

Association of the ENPP1/ENTPD1 Polymorphisms in Hemodialysis Patients

International Journal of General Medicine, 2021
Xi Zhang,1 Ziming Wan,1 Si Cheng,2 Hua Gan1 1Department of Nephrology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China; 2Department of Orthopaedics, The Second Affiliated Hospital of Chongqing Medical ...
Zhang X, Wan Z, Cheng S, Gan H
doaj  

rshikha95/CHD-SNPs: v1.0.0-CHDSNPs

<p>R Code to process SNPs from publicly available databases: an implication to congenital heart disease (CHD).</p ...
Shikha Vashisht
core   +1 more source

Supramolecular Zinc–Polyphenol Coordination Assemblies Mitigate Colonic Inflammation by Regulating Mucosal Barrier and Microbiome

Advanced Science, EarlyView.
A carrier‐free zinc‐coordinated polyphenol nanoplatform (ZnCA NPs) is designed as an “all‐in‐one” therapeutic strategy for intestinal inflammation. The ZnCA NPs exhibit enhanced colonic accumulation and broad‐spectrum reactive oxygen and nitrogen species scavenging.
Qiwen Xie, Mai Ye, Xuexia Liu, Jing Wang, Ying Chen, Lu Tan, Jinheng Fu, Xiaochang Huang   +7 more
wiley   +1 more source