Results 51 to 60 of about 499,359 (306)

Association of bovine PPARGC1A and OPN genes with milk production and composition in Holstein cattle

Czech Journal of Animal Science, 2015
Several studies have reported quantitative trait loci on chromosome 6 affecting milk production and composition traits in dairy cattle. Osteopontin (OPN) and peroxisome proliferator activated receptor-γ coactivator-1α (PPARGC1A) genes have been located ...
M. Pasandideh, M.R. Mohammadabadi, A.K. Esmailizadeh, A. Tarang   +3 more
doaj   +1 more source

Genomic Prediction of Breeding Values Using a Subset of SNPs Identified by Three Machine Learning Methods

Frontiers in Genetics, 2018
The analysis of large genomic data is hampered by issues such as a small number of observations and a large number of predictive variables (commonly known as “large P small N”), high dimensionality or highly correlated data structures.
Bo Li, Nanxi Zhang, You‐Gan Wang, A. George, A. Reverter, Yutao Li   +5 more
semanticscholar   +1 more source

Trait-Associated SNPs Are More Likely to Be eQTLs: Annotation to Enhance Discovery from GWAS

PLoS Genetics, 2010
Although genome-wide association studies (GWAS) of complex traits have yielded more reproducible associations than had been discovered using any other approach, the loci characterized to date do not account for much of the heritability to such traits and,
Dan L. Nicolae, E. Gamazon, Wei Zhang, S. Duan, M. Dolan, N. Cox, G. Gibson   +6 more
semanticscholar   +1 more source

Verification and Analysis of Sheep Tail Type-Associated PDGF-D Gene Polymorphisms

Animals, 2020
The aim of this study was to examine the correlation between the platelet-derived growth factor-D (PDGF-D) gene and sheep tail type character and explore the potential underlying mechanism. A total of 533 sheep were included in this study.
Qing Li, Zengkui Lu, Meilin Jin, Xiaojuan Fei, Kai Quan, Yongbin Liu, Lin Ma, Mingxing Chu, Huihua Wang, Caihong Wei   +9 more
doaj   +1 more source

Serum 25-hydroxyvitamin D levels and the risk of non-alcoholic fatty liver: A two-sample Mendelian randomization study

The Saudi Journal of Gastroenterology, 2023
Background: Accumulated studies have shown that low expression of 25-hydroxyvitamin D [25(OH)D] was significantly associated with the risk of non-alcoholic fatty liver disease (NAFLD). However, the exact causality is still unknown.
Qi Sheng, Huanchen Shi, Shousheng Liu, Likun Zhuang, Zhenzhen Zhao, Yongning Xin   +5 more
doaj   +1 more source

Genomic Selection for Drought Tolerance Using Genome-Wide SNPs in Maize

Frontiers in Plant Science, 2017
Traditional breeding strategies for selecting superior genotypes depending on phenotypic traits have proven to be of limited success, as this direct selection is hindered by low heritability, genetic interactions such as epistasis, environmental-genotype
Mittal Shikha, A. Kanika, A. Rao, M. Mallikarjuna, H. S. Gupta, T. Nepolean   +5 more
semanticscholar   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

NASP: an accurate, rapid method for the identification of SNPs in WGS datasets that supports flexible input and output formats.

Microbial Genomics, 2016
Whole-genome sequencing (WGS) of bacterial isolates has become standard practice in many laboratories. Applications for WGS analysis include phylogeography and molecular epidemiology, using single nucleotide polymorphisms (SNPs) as the unit of evolution.
J. Sahl, D. Lemmer, J. Travis, J. Schupp, J. Gillece, Maliha Aziz, E. Driebe, K. Drees, Nathan D Hicks, C. Williamson, Crystal M. Hepp, David Smith, Chandler C. Roe, D. Engelthaler, D. Wagner, P. Keim   +15 more
semanticscholar   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source