Results 51 to 60 of about 384,456 (306)

Unraveling the Regulatory Mechanisms Underlying Tissue-Dependent Genetic Variation of Gene Expression [PDF]

, 2012
It is known that genetic variants can affect gene expression, but it is not yet completely clear through what mechanisms genetic variation mediate this expression.
Harry J M Groen, Veldink, Jan,, Meerman, Gerard J. te,, Groen, Harry JM, Westra, Harm-Jan,, Ophoff, Roel A.,, Wolfs, Marcel G.M.,, Snieder, Harold; id_orcid, Fehrmann, Rudolf S.N.,, Fu, J, Harry J. M. Groen (101726), Groen, H.J., Fu, Jingyuan, Westra, Harm Jan, Wolfs Marcel G. M., Patrick Deelen, Westra, Harm Jan; id_orcid, Wim A Buurman, van Heel David, Weersma, RK, Groen, Harry J.M.,, Marcel G M Wolfs, Marten H. Hofker (102396), Buurman Wim A., Patrick Deelen (187548), Jansen, R.C., Fehrmann, R.S., Weersma, Rinse K; id_orcid, Harm-Jan Westra, Jansen, Ritsert C, Wijmenga, Cisca, Meerman, GJT, Cisca Wijmenga, Gerard J Te Meerman, Franke, L, Fehrmann, RSN, Rensen, SSM, Wolfs, MGM, Jingyuan Fu (102399), Weersma, Rinse K.,, Rinse K. Weersma (131692), van den Berg, Leonard H, Harold Snieder (103613), Rensen, Sander S.M.,, Fu, Jingyuan,, Fehrmann, Rudolf S N, Rensen, Sander S M, van den Berg, L.H., Sander S. M. Rensen (187559), van den Berg Leonard H., Snieder Harold, Heel, David van,, Snieder, Harold,, Leonard H van den Berg, te Meerman, G.J., te Meerman Gerard J., Ritsert C Jansen, Wolfs, M.G., Deelen, Patrick, Snieder, H., Fu Jingyuan, Deelen, P., Cisca Wijmenga (32954), Weersma, R.K., Wijmenga, Cisca,, Roel A. Ophoff (155472), Wim A. Buurman (162734), Fu, Jingyuan; id_orcid, Franke, L., Groen, Hendricus, Ophoff, RA, Wolfs, Marcel GM, Wolfs, Marcel G M, Hofker Marten H., Buurman, WA, Leonard H. van den Berg (119440), van Heel, D., Westra, H-J, Hofker, MH, Lude Franke (102406), Buurman, W.A., Jan Veldink, Groen Harry J. M., Wijmenga, C., Wijmenga Cisca, Veldink, Jan, Meerman, Gerard J te, Lude Franke, Weersma, Rinse K, Jansen, Ritsert C.,, Sander S M Rensen, Wijmenga, C, Harm-Jan Westra (102374), Westra, H.J., Veldink, J., van den Berg, LH, Snieder, Harold, David van Heel (187571), Harold Snieder, David van Heel, Westra, Harm-Jan, Rudolf S. N. Fehrmann (87558), Westra Harm-Jan, Ophoff, Roel A, Deelen Patrick, Berg, Leonard H. van den,, Rensen Sander S. M., Fehrmann, Rudolf SN, Wijmenga, Cisca; id_orcid, Roel A Ophoff, Franke, Lude, Buurman, Wim A.,, Rensen, S.S.M.; id_orcid, Groen, HJM, Ritsert C. Jansen (32125), Deelen, Patrick,, van Heel, David, Rensen, Sander SM, Franke, Lude,, Rensen, S.S.M., Weersma Rinse K., Hofker, Marten H.,, Fehrmann Rudolf S. N., Franke Lude, Jan Veldink (187567), Hofker, M.H., van Heel, D, Snieder, H, Rudolf S N Fehrmann, Buurman, Wim A, Hofker, Marten H, Deelen, P, Marten H Hofker, Veldink Jan, Jingyuan Fu, Veldink, J, Rinse K Weersma, Marcel G. M. Wolfs (187544), Jansen Ritsert C., Ophoff, R.A., Jansen, RC, Gerard J. te Meerman (87570), te Meerman, Gerhardus, Ophoff Roel A., Groen, Hendricus; id_orcid, Fu, J.   +145 more
core   +1 more source

Verification and Analysis of Sheep Tail Type-Associated PDGF-D Gene Polymorphisms

Animals, 2020
The aim of this study was to examine the correlation between the platelet-derived growth factor-D (PDGF-D) gene and sheep tail type character and explore the potential underlying mechanism. A total of 533 sheep were included in this study.
Qing Li, Zengkui Lu, Meilin Jin, Xiaojuan Fei, Kai Quan, Yongbin Liu, Lin Ma, Mingxing Chu, Huihua Wang, Caihong Wei   +9 more
doaj   +1 more source

Serum 25-hydroxyvitamin D levels and the risk of non-alcoholic fatty liver: A two-sample Mendelian randomization study

The Saudi Journal of Gastroenterology, 2023
Background: Accumulated studies have shown that low expression of 25-hydroxyvitamin D [25(OH)D] was significantly associated with the risk of non-alcoholic fatty liver disease (NAFLD). However, the exact causality is still unknown.
Qi Sheng, Huanchen Shi, Shousheng Liu, Likun Zhuang, Zhenzhen Zhao, Yongning Xin   +5 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Genome wide SNP discovery, analysis and evaluation in mallard (Anas platyrhynchos) [PDF]

, 2011
Background Next generation sequencing technologies allow to obtain at low cost the genomic sequence information that currently lacks for most economically and ecologically important organisms. For the mallard duck genomic data is limited. The mallard is,
Kerstens Hindrik HD, van Hooft, W.F., van der Poel, J.J., Prins, Herbert HT, Robert HS Kraus, van Hooft, Pim, Kraus, R.H.S., Prins, Herbert H. T., Prins, H.H.T., Poel, J., Van Hooft Pim, Hooft, Pim Van, Li Ning, Jan J Van Der Poel, Johan Elmberg, Huang Yinhua, Prins Herbert HT, Elmberg, Johan, Vignal Alain, Martien AM Groenen, Crooijmans, Richard P. M. A., Elmberg Johan, Groenen, M.A.M., van Hooft, Pim,, Van Der Poel Jan J, Huang, Y., Kraus, Robert Hs, Pim Van Hooft, Vignal, Alain, Crooijmans, R.P.M.A., Yinhua Huang, Groenen, Martien A. M., Vignal, Alain,, Li, N., Crooijmans, R., Kerstens, H., Crooijmans, Richard P. M. A.,, Herbert HT Prins, Elmberg, J., Groenen, M., Kerstens, Hindrik HD, Elmberg, Johan,, Kraus, Robert, Groenen, Martien AM, Prins, Herbert H. T.,, Kraus Robert HS, Prins, H., Huang, Yinhua,, Groenen Martien AM, Poel, J.J., van der, Kersten, H.H.D., van der Poel, Jan J., Li, Ning, Kraus, Robert H. S.,, Kraus, Robert H. S., Huang, Yinhua, Hooft, W.F., van, Crooijmans, Richard PMA, Kerstens, Hindrik H. D.,, Kerstens, Hindrik H. D., Li, Ning,, Hooft, P., Hindrik HD Kerstens, Richard PMA Crooijmans, Vignal, A., Alain Vignal, Kraus, R., Groenen, Martien A. M.,, Ning Li, Crooijmans Richard PMA, van der Poel, Jan J.,   +70 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Missense mutations in exon 2 of the porcine leptin receptor gene and their associations with litter size and body weight

Czech Journal of Animal Science, 2009
Leptin receptor (LEPR) gene is regarded as a "candidate-gene" of production traits. The aims of this study were to detect polymorphisms of exon 2 within LEPR gene and to investigate their associations with production traits, litter size and live weight ...
C. Sun, L. Wang, D. F. Jiang, B. Zhang
doaj   +1 more source

In silico analysis of CDC73 gene revealing 11 novel SNPs with possible association to Hyperparathyroidism-Jaw Tumor syndrome

The EuroBiotech Journal, 2020
Hyperparathyroidism-Jaw Tumor (HPT-JT) is an autosomal dominant disorder with variable expression, with an estimated prevalence of 6.7 per 1,000 population.
Abdelmoneim Abdelrahman H., Mohammed Alaa I., Gadim Esraa O., Mohammed Mayada Alhibir, Hamza Sara H., Mirghani Sara A., Mahmoud Thwayba A., Hassan Mohamed A.   +7 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source