Results 51 to 60 of about 423,756 (267)
Functional polymorphisms in the TERT promoter are associated with risk of serous epithelial ovarian and breast cancers [PDF]
, 2011 Genetic variation at the TERT-CLPTM1L locus at 5p15.33 is associated with susceptibility to several cancers, including
epithelial ovarian cancer (EOC). We have carried out fine-mapping of this region in EOC which implicates an association with
a single Chaiwerawattana, A, Palmieri, RT, Beesley, Jonathan, Orlow, Irene, Pickett, Hilda A., Lophatananon, A, Kelemen Linda E., Rayna K Matsuno, Kiemeney, L.A.L.M., Ingo B Runnebaum, Lurie, G., Dörk Thilo, Aben, KKH, Despierre Evelyn, Wang-Gohrke, Shan, Le, ND, Kenneth Muir, Fridley Brooke L., Lurie, Galina, Wilkens, LR, Simon A. Gayther, Natalia Antonenkova, Chaiwerawattana, A., Kiemeney Lambertus A., Wilkens Lynne R., Marees Tamara, Chaiwerawattana, Arkom, Tamara Marees, Muir, K, Vierkant, R.A., Orlow Irene, Aben Katja K. H., Marc T Goodman, Campbell, I., Rodriguez-Rodriguez Lorna, Nickels, Stefan, Menon Usha, Dunning, A.M., Wiangnon, S., Usha Menon, Sandrina Lambrechts, null null, Angela Brooks-Wilson, Wiangnon, S, Robert A Vierkant, Jenny Chang-Claude, Vrieling Alina, HASH(0x55a67f4ed3f8), Ian Campbell, Lambrechts Diether, Olson Sara H., Paul D Pharoah, Georgia Chenevix-Trench, Campbell, I, Cook, LS, Lambrechts, D., Wiangnon Surapon, Alina Vrieling, Stutz, M.D., Macgregor, Stuart, Antonenkova Natalia, Olson, S.H., Lynne R. Wilkens, Despierre, E., Caroline Baynes, Michailidou, K., Wang-Gohrke, S., Aben, K.K.H., Despierre, E, Easton Douglas F., Vrieling, A, Menon, U., Ahmed, S, Ignace Vergote, Wiangnon, Surapon, Runnebaum, I.B., Linda S. Cook, Dunning, AM, Palmieri Rachel T., Goodman, MT, Roger R. Reddel, Massuger, Leon F. A. G., Easton, DF, Massuger, L.F.A.G., Bandera, EV, Ellen L Goode, Douglas F. Easton, Antonenkova, N., Vierkant Robert A., Australian Ovarian Can Study Grp, Massuger Leon F. A. G., Bandera Elisa V., Sara H. Olson, Ahmed, S., Pickett Hilda A., Dunning Alison M., Goodman Marc T., Rodriguez-Rodriguez, Lorna, Sharon E. Johnatty, Stutz, MD, Fridley, BL, Rodriguez-Rodriguez, L, Ramus Susan J., Le, Nhu D., Runnebaum Ingo B., Brooks-Wilson Angela, Jun Li, Simon A Gayther, Nickels, S., Pharoah, P.D., Muir, Kenneth (Kenneth R.), Michailidou, Kyriaki, Cook, Linda S., Chenevix-Trench, Georgia, Brooks-Wilson, A, Ellen L. Goode, Runnebaum, IB, Ramus, S.J., Bogdanova, N, Lu, Y., Arkom Chaiwerawattana, Rider, D.N., Chang-Claude, J, Gentry-Maharaj, Aleksandra, Natalia Bogdanova, Wilkens, Lynne R., Irene Orlow, Wilkens, L.R., Leon F. A. G. Massuger, Kyriaki Michailidou, Palmieri, Rachel T., Menon, U, Investigators kConFab, Gayther, Simon A., Thilo Dörk, David N Rider, Lambertus A. Kiemeney, Kiemeney, Lambertus A., Olson, Sara H., Flesch-Janys Dieter, Li, J, ABCTB Investigators, Wang-Gohrke, S, Le Nhu D., HASH(0x55a67f3e5a40), Johnatty, S.E., Vrieling, Alina, Dork, T., Stutz Michael D., Flesch-Janys, Dieter, Baynes, C., Marees, Tamara, Michael D. Stutz, Marees, T, David N. Rider, Ingo B. Runnebaum, Lophatananon, A., Baynes, Caroline, Lambrechts, S, Orlow, I, Li Jun, Matsuno Rayna K., Baynes, C, Li, Jun, Goode, Ellen L., Reddel Roger R., Katja K H Aben, Kelemen, L.E., Goode, E.L., Lambrechts, D, Antonenkova, Natalia, Matsuno, RK, Vergote, I, Lu, Yi, Le, N.D., Lurie Galina, Rayna K. Matsuno, Lophatananon, Artitaya, Lurie, G, Susan J. Ramus, Paul D. Pharoah, Brooke L. Fridley, Leon F A G Massuger, Vergote, Ignace, Artitaya Lophatananon, Brooks-Wilson, Angela, Jonathan Beesley, Beesley, J., Baynes Caroline, Rachel T Palmieri, Fridley, B.L., Elisa V Bandera, Eilber, Ursula, Antonenkova, N, Rodriguez-Rodriguez, L., Bogdanova, N., Alison M. Dunning, Chenevix-Trench, G, Diether Lambrechts, Rachel T. Palmieri, Goodman, Marc T., Johnatty, Sharon E., Kelemen, Linda E., Hilda A. Pickett, Brooke L Fridley, Xiaoqing Chen, Surapon Wiangnon, Eilber Ursula, Nickels, S, Li, J., Goodman, M.T., Chen Xiaoqing, Johnatty,Sharon E., Pharoah, Paul D., Bogdanova, Natalia, Cook, L.S., Chaiwerawattana Arkom, Robert A. Vierkant, Linda E. Kelemen, Matsuno, R.K., Fridley, Brooke L., Chen, Xiaoqing, Lorna Rodriguez-Rodriguez, Muir, K., Evelyn Despierre, Lambrechts, Diether, Lophatananon Artitaya, Pickett, HA, Michael D Stutz, Lu Yi, Reddel, RR, Flesch-Janys, D., Bogdanova Natalia, Susan J Ramus, Gayther Simon A., Eilber, U., Sara H Olson, Shan Wang-Gohrke, Beesley Jonathan, Stefan Nickels, Massuger, LFAG, Nhu D. Le, Bandera, E.V., Gayther, S.A., Marc T. Goodman, Flesch-Janys, D, Eilber, U, Lu, Y, Michailidou Kyriaki, Pharoah, PD, Aben, Katja K.H., Gentry-Maharaj, A, Beesley, J, Stuart Macgregor, Chang-Claude Jenny, Vierkant, RA, Campbell Ian, Yi Lu, Lambertus A Kiemeney, MacGregor, S., Shahana Ahmed, Campbell, Ian, Hilda A Pickett, Lambrechts, Sandrina, Macgregor, S, Matsuno, Rayna K., Pharoah Paul D., Vergote, I., Linda E Kelemen, Easton, Douglas F., Brooks-Wilson, A., Reddel, R.R., Lambrechts Sandrina, Australian Ovarian Cancer Study Group, Reddel, Roger R., Ovarian Canc Assoc Consortium, Wang-Gohrke Shan, Olson, SH, Ovarian Cancer Association Consortium, Lambrechts, S., Chen, XQ, Aben, Katja K. H., HASH(0x55a67f6cc8d8), Dieter Flesch-Janys, Gentry-Maharaj Aleksandra, Muir Kenneth, Rider, DN, Ahmed Shahana, Ramus, SJ, Linda S Cook, Dork, T, Sharon E Johnatty, Chenevix-Trench Georgia, Nhu D Le, Menon, Usha, Dörk, Thilo, Gentry-Maharaj, A., Stutz, Michael D., Despierre, Evelyn, Ramus, Susan J., Alison M Dunning, Cook Linda S., Marees, T., Kelemen, LE, Dunning, Alison M., Runnebaum, Ingo B., Chen, X., Michailidou, K, Chen, X, Katja K. H. Aben, Johnatty Sharon E., Chang-Claude, J., Nickels Stefan, Easton, D.F., Chang-Claude, Jenny, Douglas F Easton, Roger R Reddel, Palmieri, R.T., Ahmed, Shahana, Goode Ellen L., Rider, David N., Lynne R Wilkens, Vierkant, Robert A., Chenevix-Trench, G., Aleksandra Gentry-Maharaj, Bandera, Elisa V., Macgregor Stuart, Ursula Eilber, Vrieling, A., Vergote Ignace, Pickett, H.A., Elisa V. Bandera, Rider David N., Galina Lurie, kConFab Investigators, Goode, EL, Orlow, I., Johnatty, SE, Kiemeney, LA, Gayther, SA +339 morecore +1 more sourceAugmenting and Assaying Nav1.1 Protein Quantity for Dravet Syndrome Therapy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT
Dravet Syndrome (DS) is a developmental and epileptic encephalopathy predominantly caused by heterozygous loss‐of‐function variants in SCN1A, which encodes Nav1.1. Conserved upstream open reading frames (uORFs) in SCN1A were validated to regulate translation in reporter assays, demonstrating the therapeutic viability of increasing Nav1.1 from ...Aiswarya Saravanan, Jordan Safran, Anna Loughman, Grace Lin, Shivanshi Vaid, Dana Allababidi, Peter M. Tessier, Louis T. Dang +7 morewiley +1 more sourceA High-Density Genetic Map for Cucumber (Cucumis Sativus L.) Based on Specific Length Amplified Fragment (SLAF) Sequencing and QTL Analysis of Fruit Traits in Cucumber
Frontiers in Plant Science, 2016 High-density genetic linkage map plays an important role in genome assembly and QTL fine mapping. Since the coming of next-generation sequencing (NGS), makes the structure of high-density linkage maps much more convenient and practical, which simplifies ...Wenying eZhu, Long eHuang, Long eChen, Jiantao eYang, Jiani eWu, Meiling eQu, Danqing eYao, Chunli eGuo, Hongli eLian, Huanle eHe, Junsong ePan, Run eCai +11 moredoaj +1 more sourceIntegrating Genetics With Epidemiological Measurements Identifies Burden QTLs of Inflammatory Bowel Disease across 20 Countries
Advanced Science, EarlyView.The burden quantitative trait locus (bQTL) analysis integrates epidemiological data from GBD study with genotype of 2 621 978 SNPs from 2414 individuals in 1000 Genomes Project across 20 countries. rs7633471 shows the strongest effect that each increase in centi‐allele frequency of the allele C associated with 10.00 decrease of age‐standardized ...Chen Sun, Siyu Wei, Junxian Tao, Haiyan Chen, Chi Yan, Jiacheng Wang, Jing Xu, Lian Duan, Yuanbo Zhan, Yuping Zou, Ruilin Li, Linna Yuan, Wei She, Songlin Lu, Ning Wang, Qinduo Ren, Yan Guo, Yuan Xu, Chang Wang, Hongsheng Tian, Chen Zhang, Yu Dong, Guoping Tang, Zhenwei Shang, Yongshuai Jiang, Wenhua Lv, Mingming Zhang, Hongchao Lyu +27 morewiley +1 more sourceAttomolar Detection of HIV‐1 With Label‐Free RCA‐rCRISPR on Smartphone
Advanced Science, EarlyView.A new diagnostic strategy integrating rolling circle amplification (RCA) with a plasmid reporter–based ratiometric CRISPR (rCRISPR) system was developed to detect unfragmented HIV genomes with single‐digit attomolar sensitivity. The method quantifies targets using the plasmid relaxation ratio and employs a smartphone‐based mini‐gel device to enable ...Noor Mohammad, Anastasiia Steksova, Yuyang Tang, Leyao Huang, Alireza Velayati, Shengwei Zhang, Aditi Dey Poonam, Sina Jamalzadegan, Matthew Breen, Hongjie Chen, Mahsa Bagi, Guochun Jiang, Qingshan Wei +12 morewiley +1 more sourceLactiplantibacillus Plantarum GUANKE Alleviates Allergic Asthma by Restricting Monocyte‐to‐DC Differentiation Via Microbiota‐Associated IAA
Advanced Science, EarlyView.Lactiplantibacillus plantarum GUANKE remodels the indigenous gut microbiota and is associated with microbiota‐dependent restoration of circulating IAA. IAA treatment attenuates JAK3‐STAT3 and Jag1‐Notch4‐Hey1 signaling and reduces CX3CR1+Ly6C− monocytic precursor generation and pulmonary CD11b+ DC accumulation, together with reduced Th2 inflammation ...Yujia He, Jielan Mi, Zhiping Zhao, Xiao Zhang, Zhihan Yang, Kun Yue, Yuanming Huang, Liqiong Song, Xiaoting Wen, Jianguo Xu, Zhihong Ren +10 morewiley +1 more source
