Results 61 to 70 of about 798,697 (287)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
BMC Cancer, 2017 Background Women may have incomplete understanding of a breast cancer diagnosis, leading to inaccurate reporting in epidemiological studies. However, it is not feasible to obtain consent for medical records from all women participating in a study ...
Aimee A. D’Aloisio +4 more
doaj +1 more source
Non-foundational criticality? On the need for a process ontology of the psychosocial [PDF]
, 2007 The articulation of critical dialects of psychology has typically involved a questioning of the foundational assumptions of the so-called mainstream. This has included critiques in the name of more adequate scientific foundations, but more recently these
Stenner, P.
core +1 more source
‘Walking ... just walking’: how children and young people’s everyday pedestrian practices matter [PDF]
, 2013 In this paper we consider the importance of ‘walking… just walking’ for many children and young people’s everyday lives. We will show how, in our research with 175 9-16-year-olds living in new urban developments in south-east England, some particular ...
Fuller D. +7 more
core +2 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Re-Imagining Economic Sociology. Edited by Patrik Aspers and Nigel Dodd. New York: Oxford University Press, 2015. Pp. xiii+324. $110.00. [PDF]
, 2019 Here’s a basic criterion for evaluating a social scientific theory: Does the theory make progress addressing an important, difficult “research question” that other social scientists can appreciate? This criterion seems so obvious as to be banal.
Zuckerman Sivan, Ezra W
core +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source