Results 81 to 90 of about 624,383 (304)
In Defense of the Liberal-Arts Approach to Technical Writing [PDF]
, 1982 Englis
Harris, Elizabeth
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Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
What's wrong with science? [PDF]
, 2009 Here is an idea that might help save the world. It is that science, properly understood, provides us with the methodological key to the salvation of humanity.
Maxwell, N
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Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Internal History versus External History [PDF]
, 2017 The aim of this paper is to generalize a pair of concepts that are widely used in the history of science, in art history and in historical linguistics – the concept of internal and external history – and to replace the often very ...
Aunger +51 more
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Contra Epstein, Good Explanations Predict [PDF]
Epstein has argued that an explanation\'s capacity to make predictions should play a minor role in its evaluation . This view contradicts centuries of scientific practice and, at least, decades of philosophy of science. We argue that the view is not only
Nicholas S. Thompson, Patrick Derr
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Intractable policy failure: the case of bovine TB and badgers [PDF]
, 2009 The failure to eliminate bovine TB from the English and Welsh cattle herd represents a long-term intractable policy failure. Cattle-to-cattle transmission of the disease has been underemphasised in the debate compared with transmission from badgers ...
Assembly Welsh +17 more
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LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Strong Programme against Scientific Knowledge and Its Autonomy [PDF]
, 2017 Science and scientific knowledge have been questioned in many ways for a long period of time. Especially, after the scientific revolution of 16th- and 17th-century Europe, science and its knowledge have been mainly accepted one of the most valuable and ...
Yardımcı, Alper Bilgehan
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