Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Do TV Watching and Gaming Affect Adolescents’ Social Acceptance Among Classmates?
YouthSocial acceptance among peers is an important predictor of adolescents’ academic and social outcomes. This study investigates how social acceptance depends on adolescents’ engagement in watching TV and gaming. Based on Contact Theory, we expected that TV
Verena Hofmann +3 more
doaj +1 more source
Explanatory model of the psychosocial variables related to the social acceptance of a uranium mine project in northwest Spain. [PDF]
Front Psychol, 2023 Sánchez-Tabernero G +3 more
europepmc +1 more source
Overcoming Expert Disagreement In A Delphi Process. An Exercise In Reverse Epistemology [PDF]
, 2015 Disagreement among experts is a central topic in social epistemology. What should an expert do when confronted with the different opinion of an epistemic peer?
Elisabetta, Lalumera
core +2 more sources
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Diverse families: Challenges and social acceptance
Revista de Ciencias SocialesThe family is a social institution that has evolved by adapting to diversity and reflecting historical, economic, cultural, geographic, and political changes.
Yuly Inés Liñán Cuello +2 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Physiological measurements in social acceptance of self driving technologies. [PDF]
Sci Rep, 2022 Palatinus Z +11 more
europepmc +1 more source
What drives consumers' e-loyalty to airlines web site? Conceptual framework and managerial implications [PDF]
, 2011 This study proposes a revised technology acceptance model that integrates expectation confirmation theory to measure continuance intentions of online shopping for airlines web sites. The sample respondent 465online users in Saudi Arabia.
Al-Maghrabi, T, Basahel, A, Kamal, M
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source