Results 111 to 120 of about 12,916,776 (308)

The Classic-Novel Adaptation from 1995 to 2009 [PDF]

open access: yes, 2010
This thesis explores the dynamic relationship between the nineteenth-century novel and the screen, interrogating evolving trends in film and television adaptation from the mid-1990s to 2009.
WHITE, REBECCA,ARWEN
core  

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Pro-Poor Urban Adaptation to Climate Change : Based on Case Studies in Kenya and Nicaragua

open access: yes, 2010
Poor urban populations in Southern cities are already experiencing the negative impacts of changing weather patterns associated with climate change and climate variability and future projections suggest that
Norton, Andrew   +3 more
core   +1 more source

Building a Model of Social and Psychological Adaptation

open access: yesSSRN Electronic Journal, 2017
The paper presents a model for social and psychological assistance to militaries discharged of service and the members of their families through the example of Bulgaria which has the potential to be a basis for the creation of an adaptive program and setting up criteria for efficiency in it.
openaire   +4 more sources

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Climate Adaptation decision support Tool for Local Governments: CATLoG [PDF]

open access: yes, 2013
The Intergovernmental Panel on Climate Change (IPCC), the globally-recognised reference body for climate-related research, describes warming of the climate system as ‘unequivocal’.
Supriya Mathew   +2 more
core  

Reconceptualising adaptation to climate change as part of pathways of change and response [PDF]

open access: yes, 2014
The need to adapt to climate change is now widely recognised as evidence of its impacts on social and natural systems grows and greenhouse gas emissions continue unabated.
Park, Sarah   +20 more
core   +1 more source

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