Results 131 to 140 of about 12,916,776 (308)
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Migrant Social Integration: Key Obstacles and Pathways to Effective Adaptation [PDF]
The study of the social integration of migrants is of great theoretical and practical importance. Identifying patterns and features of migration allows us to model strategies for successfully adapting migrants.
Логвиненко, Вікторія Михайлівна +5 more
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Institutional governance barriers for the development and implementation of climate adaptation strategies [PDF]
, 2009 In this paper we summarise the main social barriers to adaptation presented in climate literature – the inherent uncertainty of climate change, fragmentation, institutional voids, short term horizon of politicians and policies, and the motives and ...
Termeer, C.J.A.M. +3 more
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Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
The role of water markets in climate change adaptation [PDF]
, 2013 Water markets were first introduced in Australia in the 1980s, and water entitlement and allocation trade have been increasingly adopted by both private individuals and government.Irrigators turned to water markets (particularly for allocation water) to ...
Adam Loch +2 more
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Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Adaptation and Development: Whose Goals and Priorities Count?
, 2010 It has been argued that adaptation to climate change should be integrated with development activities, and that it is time to pursue its 'mainstreaming' within such programmes (Burton 2009).
Nalau, Johanna, Heyd, T.
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Adaptation to climate in widespread eucalypt species [PDF]
, 2013 The long term success of revegetation efforts will depend upon the planted species’ resilience to climate change. Many widespread species grow across a range of climatic conditions and, thus, may possess adaptations that could be utilised to improve ...
Suzanne Prober +2 more
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SOCIAL-PSYCHOLOGICAL ADAPTATION IN ORGANIZATIONS OF PERM NETWORK BUSINESS
Вестник университета, 2019 The article deals with actual problems of workers' adaptation in the conditions of modern network business organizations as one of the elements of the application of a scientific approach for the growth of labor productivity.
V. Levchenko, E. Zykovа
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