Results 141 to 150 of about 1,770,192 (303)

R&D managers’ adaptation of firms’ HRM practices. [PDF]

open access: yes
The heads of R&D departments are those most responsible for the adaptation of firms’ human resource management (HRM) practices to the idiosyncrasies of their departments.
Ortín, Pere, Santamaría, Lluís
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

Effect of Intergenerational Trends on Parental Child-Rearing Gender Role Attitudes (PCGAs) in Single-Parent Families: A Relative Mediation

open access: yesBehavioral Sciences
Family structures are diverse, with single-parent families being special. Single-parent families have garnered interest regarding their impact on their children’s development in relation to gender roles and social adaptation.
Yunping Song   +4 more
doaj   +1 more source

Reviewing agent-based modelling of socio-ecosystems: a methodology for the analysis of climate change adaptation and sustainability [PDF]

open access: yes
The integrated - environmental, economic and social - analysis of climate change calls for a paradigm shift as it is fundamentally a problem of complex, bottom-up and multi-agent human behaviour.
Carlo Giupponi, Stefano Balbi
core  

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

ESCAPISM AS THE DEVIATION IN THE YOUTH'S SOCIALIZATION

open access: yesВестник Кемеровского государственного университета, 2013
In article the main sociological approaches to the phenomenon of escapism are considered. The connection of es capism with the processes of society marginalization is shown.
N. V. Nyatina
doaj  

Molecular cancer prevention: Intercepting disease

open access: yesMolecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco   +2 more
wiley   +1 more source

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