Results 151 to 160 of about 1,770,192 (303)

Leaving Nothing to Chance: Modeling the Proactive Structuration of a New Technology [PDF]

open access: yes
Adaptive structuration theory (AST, DeSanctis and Poole 1994) describes how people come to understand and use a technology. In this paper we develop the idea of proactive structuration--how social networking can be proactively managed in order to speed ...
Fuller, Mark A.   +2 more
core  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Дети-мигранты: современные акценты научных исследований в России

open access: yesProblemy Wczesnej Edukacji, 2016
The article provides an analysis of trends and approaches to researching foreign language learning problems, social and psychological adaptation, and the integration of migrant children in the multiethnic educational institutions of Russia.
Irina Simaeva
doaj  

Italy: Delayed adaptation of social institutions to changes in family behaviour [PDF]

open access: yes
Considering its very low fertility and high age at childbearing, Italy stands alone in the European context and can hardly be compared with other countries, even those in the Southern region.
Alessandra De Rose   +2 more
core  

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

open access: yesFEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold   +11 more
wiley   +1 more source

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