Results 171 to 180 of about 409,513 (309)

Challenges and social adaptation of international students in Saudi Arabia. [PDF]

Heliyon, 2023
Alasmari AA.
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

From research to capacity, policy and action : enabling adaptation to climate change for poor populations in Asia through research, capacity building and innovation; report from the Adaptation Team to IDRC

, 2008
The report organizes and presents detailed results from the analysis that worked to identify areas where strategically targeted research and capacity building programmes could support adaptation to climate change.
Institute for Social and Environmental Transition (ISET), Adaptation Study Team
core  

Research communication for immediate impact: climate adaptation in Australia [PDF]

, 2015
Research into climate change adaptation is challenged by funding organisations to demonstrate immediate research impact through near term reference in sector- specific communication and policy documents.
Liese Coulter, John Zhong, David Rissik
core  

Дети-мигранты: современные акценты научных исследований в России

Problemy Wczesnej Edukacji, 2016
The article provides an analysis of trends and approaches to researching foreign language learning problems, social and psychological adaptation, and the integration of migrant children in the multiethnic educational institutions of Russia.
Irina Simaeva
doaj  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Parental Burnout and Adolescents' Development: Family Environment, Academic Performance, and Social Adaptation. [PDF]

Int J Environ Res Public Health, 2023
Wang W, Chen S, Wang S, Shan G, Li Y.
europepmc   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Community-based Adaptation: Lessons from the Development Marketplace 2009 on Adaptation to Climate Change [PDF]

The Development Marketplace 2009 focused on adaptation to climate change. This paper identifies lessons from the Marketplace and assesses their implications for adaptation support.
Habiba Gitay, Radhika Prabhu, Rasmus Heltberg   +2 more
core  

Beyond tools: building learning organisations to adapt to a changing climate [PDF]

, 2013
Executive summary: The focus of this VCCCAR Visiting Fellowship was participation in the project ‘Implementing tools to increase adaptive capacity in the community and natural resources management sectors’.
Kate Lonsdale
core