Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
The relationship between social avoidance, behavioral self-regulation, and social adjustment among Chinese Kindergartners. [PDF]
BMC PsycholZhu J, Shen Y, Li Y.
europepmc +1 more source
Social Avoidance and Social Adjustment in Chinese Preschool Migrant Children: The Moderating Role of Household Chaos and Gender. [PDF]
Int J Environ Res Public Health, 2022 Zhu J, Yin X, Wang G, Jiang Y, Li Y.
europepmc +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Mentalizing difficulties are transdiagnostic and explain links between mental health and neurodevelopmental symptoms and social adjustment in school-aged children. [PDF]
JCPP AdvDevine RT, Byrne I, Kovatchev V.
europepmc +1 more source
Impact of virtual group-based acceptance and commitment therapy on social adjustment and work-family conflict among intern nurses: a randomized control trial. [PDF]
BMC Psychiatry, 2023 El-Ashry AM +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Perceived teacher support moderate the relationships between adverse childhood experiences and social adjustment among migrant children: a latent profile analysis. [PDF]
BMC PsychiatryWang F, Ma X.
europepmc +1 more source
Empirically Derived Psychological Profiles of College Students: Differential Associations With COVID-19 Impact and Social Adjustment. [PDF]
Emerg Adulthood, 2022 Kochel KP, Bagwell CL, Abrash RW.
europepmc +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source