Results 41 to 50 of about 7,401,341 (346)
Complex networks vulnerability to module-based attacks
, 2015 In the multidisciplinary field of Network Science, optimization of procedures for efficiently breaking complex networks is attracting much attention from practical points of view. In this contribution we present a module-based method to efficiently break
da Cunha, Bruno Requião +2 more
core +3 more sources
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Amnis, 2003 If one looks today, with the historian's eyes, the South Cone at the end of the sixties and seventies and then, by continuation, turns a page of some years to fix the same part of the world, the report is very clear: the Latino-American subcontinent ...
Franck Gaudichaud
doaj +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
, 2020 At least in Russia–and China–the age of euphoria prominent 30 years ago is gone. The church missions committed to short-term gains have left for greener pastures and the congregations remaining behind are now, more than ever, required to determine their ...
Yoder, William
core
Parties and Ballot Access in Latin America: a new trend in a new political context [PDF]
, 2013 For the last ten years a group of Latin American countries have passed legal reforms raising ballot access requirements. Although each of these reforms have been profusely discussed in every one of the countries involved, so far, they have not been ...
Scherlis Perel, Gerardo Ezequiel
core
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Медіафорум: аналітика, прогнози, інформаційний менеджмент, 2020 The article explores formation of new ideals and values that has become a key task of the European community after overcoming totalitarianism. Many researchers of that time were looking for methods to prevent atomization and establish democracy, and one ...
Mykola Luchak, Anna-Maria Luchak-Fokshei
doaj +1 more source
The COVID-19 Pandemic in the Social Teaching of the Roman Catholic Church
Vestnik MGIMO-Universiteta, 2021 The COVID-19 pandemic exposed the critical problems of the structure not only of the modern health system but also of the role of the state in managing socio-economic processes, government institutions, and their ability to ensure the safety and well ...
H. T. Sardaryan
doaj +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source