Results 61 to 70 of about 287,277 (297)
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
Online experience sharing without explicit social interaction does not foster social bonding
Cyberpsychology: Journal of Psychosocial Research on CyberpspaceHumans have a unique capacity to bond with others through shared experiences, even in the absence of explicit communication. Yet it is unknown whether this capacity is flexible enough to accommodate the different kinds of virtual environments on which ...
Wouter Wolf, Kayley Dotson
doaj +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Social Brain Perspectives on the Social and Evolutionary Neuroscience of Human Language
Brain SciencesHuman language and social cognition are two key disciplines that have traditionally been studied as separate domains. Nonetheless, an emerging view suggests an alternative perspective.
Nathan Oesch
doaj +1 more source
Typology and Reasons for Murder Using Grounded Theory [PDF]
مسائل اجتماعی ایران, 2018 Present study aims at typology and motives of murder convicts in Rasht Lakan prison. By means of qualitative method, this research conducted 10 individual and 3 as a group in-depth semi-structured interviews.
Ali Yaghoobi Choobari
doaj
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Zygon, 2021 The evolutionary cognitive science of religion rarely strays far from strong individualistic principles despite a deep interest in the adaptive social bonding functions of religion.
doaj +2 more sources
Social bonds and genetic ties: Kinship association and affiliation in a community of bonobos (Pan paniscus) [PDF]
, 1999 Studies of captive populations of bonobos suggest that females are more gregarious than males. This seems to contradict assumed sex-differences in kinship deriving from a speciestypical dispersal pattern of female exogamy and male philopatry.
Fruth, Barbara +3 more
core +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source