Results 121 to 130 of about 7,065,483 (350)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Witnessing: iteration and social change. [PDF]

AI Soc, 2022
McPherson E.
europepmc   +1 more source

Replication Data for: Social Contact and Outgroup Bias: World Cup Matches and Changes in Outgroup Bias

, 2023
Jong Hee Park
openalex   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Knowledge and Social Change: Impact of 40 Years of Health and Population Communication in Egypt [PDF]

, 2020
Farag Elkamel
openalex   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Access to surgery in Ecuador using the enhanced 2-step floating catchment area approach

BMC Global and Public Health
Background Traditional surgical access metrics are often presented at the national level, providing poor insight for local policy makers. The Enhanced Two-Step Floating Catchment Area (E2SFCA) method is an alternative to current methods with two key ...
Taylor Wurdeman, Alejandro Torres Balarezo, Alfredo Borrero Vega, Tanujit Dey, Maria Falconi, Maria José Garcia, Mateo Iza, Nikathan Kumar, Ayla Gerk, Zachary Fowler, Edgar Rodas, Juan Carlos Salamea, Sabrina Juran, John G. Meara, Tarsicio Uribe-Leitz   +14 more
doaj   +1 more source

Government scholarships for international higher education: pathways for social change in Kazakhstan. [PDF]

High Educ (Dordr), 2023
Jonbekova D.
europepmc   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Resilience and social change: Findings from research trends using association rule mining. [PDF]

Heliyon, 2023
Kim C, Yeom J, Jeong S, Chung JB.
europepmc   +1 more source