Results 121 to 130 of about 27,162,291 (391)
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Respecifying social change: the obsolescence of practices and the transience of technology. [PDF]
Front Sociol, 2023 Mlynář J, Arminen I.
europepmc +1 more source
Social Change: The Sexual Revolution [PDF]
In 1900 only six percent of unwed females engaged in premarital sex. Now, three quarters do. The sexual revolution is studied here using an equilibrium matching model, where the costs of premarital sex fall over time due to technological improvement in ...
Jeremy Greenwood, Nezih Guner
core
Distance learning certificate course: legislative drafting for democratic social change [PDF]
, 2000 Correspondence and course description document for the Boston University School of Law's Distance Learning Certificate Course in Legislative Drafting for Democratic Social Change, which had been made available for the first time on the Internet, from ...
Seidman, Ann, Seidman, Robert B.
core
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Asset Building for Social Change: Pathways to Large-Scale Impact [PDF]
, 2004 Provides an in-depth examination of current and historic initiatives, in an effort to discern patterns of successful scaling up from among Ford's Assets Program portfolios ...
core
Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source
, 2011 In the social and communication sciences, social change has traditionally been associated with “development problems” that occurred in “developing countries.” It is only since the late 1980s and early 1990s that social change has become a global issue.
openaire +2 more sources