Results 61 to 70 of about 134,426 (309)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

The evolution and predicament of modern social technicalization

open access: yesCultures of Science, 2023
Social technicalization refers to the construction and operation of society in accordance with the principles of technology. The stage of modern social technicalization was spawned after the Industrial Revolution and has mainly been manifested in two ...
Jie Song
doaj   +1 more source

Content Construction of Web Information Resources for the Good of Science and Technology System Dynamics Study

open access: yesZhishi guanli luntan, 2023
[Purpose/Significance] Analyze and study how to promote the construction of network information resource content for good in the face of science and technology, clarify its internal promotion mechanism, and provide a steady stream of internal impetus ...
Aiqin Liu, Shaopeng Guo, Shan Shang
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

open access: yesFEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Social work as narrative: An investigation of the social and literary nature of social work accounting [PDF]

open access: yes, 1993
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.This thesis investigates what can be gained by approaching social work reports and conversations as narratives.
Hall, Christopher J, Hall, C.J
core  

Planning and implementation of effective collaboration in construction projects [PDF]

open access: yes, 2007
The 21st century is now seen as the time for the construction industry to embrace new ways of working if it is to continue to be competitive and meet the needs of its ever demanding clients.
Shelbourn, M   +3 more
core   +1 more source

Compressed Air Technology in Swedish Archaeology: An Example of the Social Construction of Technology in Practice

open access: yesCurrent Swedish Archaeology, 2006
In this paper the authors problematize the relation between technological and social aspects of archaeological fieldwork through a historical case study of the introduction and use of compressed air technology in archaeology.
Åsa Gillberg, Ola W. Jensen
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Identifying stakeholder motivations in normative AI governance: a systematic literature review for research guidance

open access: yesData & Policy
Ethical guidelines and policy documents destined to guide AI innovations have been heralded as the solution to guard us against harmful effects or to increase public value. However, these guidelines and policy documents face persistent challenges.
Frederic Heymans, Rob Heyman
doaj   +1 more source

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