Results 61 to 70 of about 133,886 (308)

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

The social construction of facts and artefacts: or How the sociology of science and the sociology of technology might benefit each other [PDF]

, 1984
The need for an integrated social constructivist approach towards the study of science and technology is outlined. Within such a programme both scientific facts and technological artefacts are to be understood as social constructs.
Bijker, Wiebe E., Pinch, Trevor J., Bijker, Wiebe E.; id_orcid   +2 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

A structural approach of the AI social representations. Robot humanizing technology?

Ψυχολογία: το Περιοδικό της Ελληνικής Ψυχολογικής Εταιρείας
Strongly related to a “technological mythology” referred to Promethean promises and threats, Artificial Intelligence draws increasingly impressive attention from the media, as well as from the lay public.
Patricia Gerakopoulou, Nikolas Christakis   +1 more
doaj   +1 more source

Co-creating social value through cross-sector collaboration between social enterprises and the construction industry

, 2022
Emerging social procurement imperatives are driving new forms of cross-sector collaboration between private, public and social enterprise sectors in the construction industry.
Barraket, J, Loosemore, M
core   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

CLUSTER OF INFORMATION TECHNOLOGY (IT) IN THE SOUTHWEST OF PARANÁ: PARADIGMATIC CHANGES OF INNOVATION TO THE SOCIAL DIMENSION

Redes, 2015
This article proposes the analysis of the concepts of innovation and design of the social aspect in the construction of possible models of social perception, contributing to the building of technological knowledge and changes to environmental rationality.
Rafael Henrique Mainardes Ferreira, Nilvania Aparecida de Mello, Miguel Ângelo Perondi, Gilson Ditzel Santos   +3 more
doaj   +1 more source

Rethinking the Social Construction of Technology Through 'Following the Actors': A Reappraisal of Technological Frames [PDF]

In this paper, I summarize case study research on an information system called Connected Kids. This case study was guided by an approach to technology studies called the \'Social construction of technology\' or SCOT Bijker (1984). In discussing Connected
Christina Prell Not available for reviewing until Oct 2010
core  

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source