Results 101 to 110 of about 2,479,930 (314)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Multi-dimensional perspectives on sustainability in domestic waste management [PDF]

Global Journal of Environmental Science and Management
BACKGROUND AND OBJECTIVES: Sustainable waste management is a critical global challenge, demands a multifaceted approach to evaluate and boost its effectiveness.
Y. Ismail, R. Adji, A.D. Santoso, S. Wahyono, M.A. Kholiq, T. Handayani, S.D.R. Pahri, S. Putiamini, R.A. Pratama, F. Nurfatriani, F.L. Sahwan, F. Suryanto, Prasetiyadi ,, R.D. Tilottama   +13 more
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

New Voices: What Works [PDF]

, 2010
Reviews grantees' accomplishments in building community news sites, keys to sustainability, and lessons learned about engagement, staffing, business models, social media, technology, partnerships, and limitations of university, youth, and radio ...
Jan Schaffer
core  

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Social Networking Sites and Our Lives [PDF]

, 2011
Examines the characteristics of social networking site users, their online activities, and their friendships, sense of trust, social support, perspectives, and civic engagement by site and compared with those of non-users and users of other ...
Keith N. Hampton, Kristen Purcell, Lauren Sessions Goulet, Lee Rainie   +3 more
core  

Overdose education and naloxone distribution in jails: Examining the impact of the Communities That HEAL intervention in 4 states

Health & Justice
Background Opioid-related overdose is the leading cause of mortality among individuals recently released from incarceration in the U.S. Naloxone is an FDA-approved opioid antagonist medication designed to rapidly reverse opioid overdose. Despite evidence
Timothy Hunt, Carrie B. Oser, Peter D. Friedmann, Nicole Mack, Peter Balvanz, Bridget Freisthler, Redonna K Chandler, Karli Hochstatter, Daniel R. Harris, LaShawn Glasgow, Lauren D’Costa, Mary R. Russo, Barry Eggleston, Arnie Aldridge, Paul Bellair, Allyson G. Cogan, James L. David, Nabila El-Bassel, Dawn Goddard-Eckrich, Steve Gomori, Holly Hagan, Steve Hanson, JaNae Holloway, Elizabeth N. Kinnard, Charlie Knott, Michael W. Konstan, Sharon L. Walsh, Patricia A. LeBaron, Michael S. Lyons, Margaret McGladrey, Joan Papp, Sean M. Murphy, Sandra Springer, Emmanuel Oga, Michele Staton, Elizabeth Schady, Fernando Montero, Hilary L. Surratt, Danelle Stevens-Watkins, John Winhusen, Gary A. Zarkin, Greer A. Hamilton, Joel G. Sprunger   +42 more
doaj   +1 more source

Gauging public sentiments toward foot-and-mouth disease outbreak control: A scoping review 2003–2022

CABI One Health
Foot-and-mouth disease (FMD) is a highly transmissible viral infection of cloven-hoofed animals. As part of a larger programme of research directed towards preparing Australia for an FMD incursion, this scoping literature review aimed to identify and ...
Cheryl Travers, Nicole Schembri, Chris Degeling   +2 more
doaj   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Beyond Buildings: How Does Sustainable Campus Design Shape Student Lives? Hail University as a Case Study

Buildings
Sustainable campus design plays a vital role in shaping student well-being, academic performance, and institutional adaptability. This study investigates how sustainable design strategies influence student life at Hail University, Saudi Arabia, a campus ...
Emad Noaime, Mohammad Alshenaifi, Ghazy Albaqawy, Mohammed Awad Abuhussain, Mohamed Hssan Hassan Abdelhafez, Mohammed Mashary Alnaim   +5 more
doaj   +1 more source